Cutaneous T-cell lymphoma: 2016 update on diagnosis, risk-stratification, and management

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Cutaneous T-cell lymphoma: 2016 update on diagnosis, risk-stratification, and management is …
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P356DOI10.1002/AJH.24233
P932PMC publication ID4715621
P698PubMed publication ID26607183

P2093author name stringRyan A Wilcox
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Is interferon alpha in cutaneous T-cell lymphoma a treatment of choice?Q68030159
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A histologic study of lymph nodes from patients with the Sézary syndromeQ69992670
Recombinant leukocyte A interferon: an active agent in advanced cutaneous T-cell lymphomasQ70224653
Candidate counterparts of Sézary cells and adult T-cell lymphoma-leukaemia cells in normal peripheral blood: an ultrastructural study with the immunogold method and monoclonal antibodiesQ71001264
Methotrexate is effective therapy for lymphomatoid papulosis and other primary cutaneous CD30-positive lymphoproliferative disordersQ71019976
Combined modality therapy for cutaneous T-cell lymphomaQ71120115
Dermatopathic lymphadenopathy and lymph node involvement in mycosis fungoidesQ71128945
Differential expression of CD3 and CD7 in T-cell malignancies: a quantitative study by flow cytometryQ71248580
HLA-DR5 and DQB1*03 class II alleles are associated with cutaneous T-cell lymphomaQ71381368
Detection of circulating T cells with CD4+CD7- immunophenotype in patients with benign and malignant lymphoproliferative dermatosesQ71477713
Systemic chemotherapy and extracorporeal photochemotherapy for T3 and T4 cutaneous T-cell lymphoma patients who have achieved a complete response to total skin electron beam therapyQ71868434
Long-term follow-up of patients with cutaneous T-cell lymphoma treated with extracorporeal photochemotherapyQ71874205
Immunophenotypic identification of Sezary cells in peripheral bloodQ71938114
Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implicationsQ37512907
Clinical studies of histone deacetylase inhibitors.Q37512917
Skin-resident T cells: the ups and downs of on site immunityQ37579039
High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.Q37635287
Current and emerging treatment strategies for cutaneous T-cell lymphomaQ37694527
Pralatrexate: basic understanding and clinical developmentQ37761372
Cancer-associated myeloproliferation: old association, new therapeutic targetQ37769017
Histone deacetylase inhibitors in the treatment of lymphomaQ37814536
Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome.Q37929548
Cutaneous T-cell lymphoma: 2011 update on diagnosis, risk-stratification, and managementQ37944565
Allogeneic stem cell transplantation for advanced primary cutaneous T-cell lymphoma: a systematic reviewQ38028137
U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphomaQ38042090
STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytesQ38311269
Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cellsQ38323614
Prevalence and clinical association of clonal T-cell expansions in Myelodysplastic SyndromeQ38463964
A three-signal model of T-cell lymphoma pathogenesisQ38593164
PLCG1 mutations in cutaneous T-cell lymphomasQ39027098
Dysregulated synthesis of intracellular type 1 and type 2 cytokines by T cells of patients with cutaneous T-cell lymphoma.Q39506116
Reduction of Fas/CD95 promoter methylation, upregulation of Fas protein, and enhancement of sensitivity to apoptosis in cutaneous T-cell lymphomaQ39617721
STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL.Q39730561
Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistanceQ39744464
Report of the Committee on Pathology of Cutaneous T Cell LymphomasQ39795737
Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in cutaneous T cell lymphomaQ39883430
Low FAS/CD95 expression by CTCL correlates with reduced sensitivity to apoptosis that can be restored by FAS upregulationQ39928789
High numbers of DC-SIGN+ dendritic cells in lesional skin of cutaneous T-cell lymphomaQ39933137
Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphomaQ39981886
Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cellsQ40012160
Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma down-regulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agentsQ40017228
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphomaQ40070617
Regulation of the HIF-1alpha stability by histone deacetylasesQ40175660
Circulating natural killer lymphocytes are potential cytotoxic effectors against autologous malignant cells in sezary syndrome patientsQ40340093
Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphomaQ40341141
Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic actionQ40349894
Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis.Q40362906
Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activityQ40401113
Phase II evaluation of gemcitabine monotherapy for cutaneous T-cell lymphoma.Q40473507
Phase 2 study of alemtuzumab (anti-CD52 monoclonal antibody) in patients with advanced mycosis fungoides/Sezary syndromeQ40566975
The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells.Q40567775
Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignanciesQ40623388
Pentostatin therapy of T-cell lymphomas with cutaneous manifestationsQ40632049
Combination treatment with extracorporeal photopheresis, interferon alfa and interleukin-2 in a patient with the Sézary syndromeQ40637906
A randomized trial comparing combination electron-beam radiation and chemotherapy with topical therapy in the initial treatment of mycosis fungoidesQ40768413
Constitutive expression of NF-kappa B is a characteristic feature of mycosis fungoides: implications for apoptosis resistance and pathogenesisQ40833205
Interferon in the treatment of cutaneous T-cell lymphomaQ40923577
Low-dose methotrexate to treat erythrodermic cutaneous T-cell lymphoma: results in twenty-nine patientsQ40970585
Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression.Q41071715
Histopathological and immunophenotypical criteria for the diagnosis of Sézary syndrome in differentiation from other erythrodermic skin diseases: a European Organisation for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Task Force StudQ41086530
Treatment of cutaneous T-cell lymphoma with extracorporeal photopheresis monotherapy and in combination with recombinant interferon alfa: a 10-year experience at a single institutionQ41262862
Mycosis fungoides in relation to environmental exposures and immune response: a case-control studyQ41327858
Depletion of regulatory T cells by targeting CC chemokine receptor type 4 with mogamulizumabQ41591884
PCR-heteroduplex analysis of T-cell receptor gamma gene rearrangement in paraffin-embedded skin biopsiesQ41756642
Phase II trial of pentostatin in refractory lymphomas and cutaneous T-cell diseaseQ41998297
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cellsQ42156460
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.Q42163084
Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cellsQ23909995
Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73Q24302209
Acetylation is indispensable for p53 activationQ24313477
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylationQ24649964
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)Q24681480
Cutaneous T-cell lymphoma: 2014 update on diagnosis, risk-stratification, and managementQ27024076
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphomaQ27824784
Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndromeQ28204642
CCL27-CCR10 interactions regulate T cell-mediated skin inflammationQ28217086
Recurring structural chromosome abnormalities in peripheral blood lymphocytes of patients with mycosis fungoides/Sézary syndromeQ28236693
Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary resultsQ28300282
The optimal use of bexarotene in cutaneous T-cell lymphomaQ28305252
Quantitative PCR on 5 genes reliably identifies CTCL patients with 5% to 99% circulating tumor cells with 90% accuracyQ30477329
Extracorporeal photopheresis for the treatment of erythrodermic cutaneous T-cell lymphoma: a single center clinical experience with long-term follow-up data and a brief overview of the literatureQ30650570
Induction of MAGE-3 expression in lung and esophageal cancer cellsQ32054392
Are alcohol intake and smoking associated with mycosis fungoides? A European multicentre case-control studyQ32142148
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphomaQ33375600
Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphomaQ33376304
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphomaQ33386623
Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphomaQ33387258
Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL studyQ33393701
Identification of an active, well-tolerated dose of pralatrexate in patients with relapsed or refractory cutaneous T-cell lymphomaQ33400117
A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphomaQ33418737
Therapy with gemcitabine in pretreated peripheral T-cell lymphoma patientsQ33505113
GATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical featuresQ33585286
Prognostic factor analysis in mycosis fungoides/Sézary syndromeQ33655920
HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapyQ33778769
Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphomaQ33783663
Oncogenic activation of NF-kappaB.Q33849388
Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activationQ33863049
Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. French Study Group of Cutaneious LymphomasQ33873334
Tumor-associated macrophages and survival in classic Hodgkin's lymphomaQ33962334
Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviorsQ34052608
Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signalingQ34110250
WHO-EORTC classification for cutaneous lymphomasQ34391006
Defining early mycosis fungoides.Q34470437
Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous LymphomasQ34470582
Absence of CD26 expression is a useful marker for diagnosis of T-cell lymphoma in peripheral bloodQ34515597
Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).Q34520098
Single agent and combination studies of pralatrexate and molecular correlates of sensitivityQ34543815
Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and TreatmentQ34633209
High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma.Q34667769
The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.Q34672100
Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.Q34802998
Guidelines on the use of extracorporeal photopheresisQ34918643
How I treat mycosis fungoides and Sézary syndromeQ34998601
Molecular cytogenetic characterization of Sézary syndromeQ35056476
Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsiesQ35065024
Extracorporeal photochemoimmunotherapy in cutaneous T-cell lymphomaQ35079273
Expression of histone deacetylases in lymphoma: implication for the development of selective inhibitors.Q35235267
Low-dose methotrexate to treat mycosis fungoides: a retrospective study in 69 patientsQ35567170
Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells.Q35586076
Retinoids: therapeutic applications and mechanisms of action in cutaneous T-cell lymphomaQ35612029
The treatment of cutaneous T-cell lymphoma with photopheresisQ35612038
Topical and systemic retinoid therapy for cutaneous T-cell lymphomaQ35622824
Resimmune, an anti-CD3ε recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphomaQ35669880
Increased programmed death-1 expression on CD4+ T cells in cutaneous T-cell lymphoma: implications for immune suppressionQ35742964
Clinicopathological spectrum of mycosis fungoidesQ35804408
Discordant expression of antigens between intraepidermal and intradermal T cells in mycosis fungoidesQ35812147
Transformation of cutaneous T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic studyQ35818912
Interleukin-7 is a growth factor for Sézary lymphoma cellsQ35822493
Early lymphocyte recovery predicts superior survival after autologous stem cell transplantation in non-Hodgkin lymphoma: a prospective studyQ35827808
Effectiveness of interferon alfa-2a combined with phototherapy for mycosis fungoides and the Sézary syndromeQ72354154
Combination chemotherapy in the tumour stage of mycosis fungoides with cyclophosphamide, vincristine, vp-16, adriamycin and prednisolone (cop, chop, cavop): a report from the Scandinavian mycosis fungoides study groupQ72628181
Induction of nuclear contour irregularity during T-cell activation via the T-cell receptor/CD3 complex and CD2 antigens in the presence of phorbol estersQ72666167
Phase II trial of fludarabine phosphate and interferon alfa-2a in advanced mycosis fungoides/Sézary syndromeQ72729394
Diagnostic Criteria in Sézary's Syndrome: A Multiparameter Study of Peripheral Blood Lymphocytes in 32 Patients with ErythrodermaQ72797631
Th2 cytokine mRNA expression in skin in cutaneous T-cell lymphomaQ72813178
The role of pentostatin in the treatment of T-cell malignancies: analysis of response rate in 145 patients according to disease subtypeQ72880108
Chemotherapy with etoposide, vincristine, doxorubicin, bolus cyclophosphamide, and oral prednisone in patients with refractory cutaneous T-cell lymphomaQ73042497
Drug-induced reversible lymphoid dyscrasia: a clonal lymphomatoid dermatitis of memory and activated T cellsQ73069370
Treatment of relapsing or recalcitrant cutaneous T-cell lymphoma with pegylated liposomal doxorubicinQ73294418
Sezary lineage cells can be induced to proliferate via CD28-mediated costimulationQ73326156
Increased interleukin 5 production in eosinophilic Sézary syndrome: regulation by interferon alfa and interleukin 12Q73372085
Expression of apoptosis markers on peripheral blood lymphocytes from patients with cutaneous T-cell lymphoma during extracorporeal photochemotherapyQ73372093
Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lymphomaQ73396460
Pentostatin (2'-deoxycoformycin) in the treatment of cutaneous T-cell lymphomaQ73468261
Extracorporeal photopheresis and interferon-α in advanced cutaneous T-cell lymphomaQ73499034
Induction of human tumor-loaded dendritic cellsQ73623155
Mycosis fungoides: disease evolution and prognosis of 309 Dutch patientsQ73684481
Long-term outcome of 525 patients with mycosis fungoides and Sezary syndrome: clinical prognostic factors and risk for disease progressionQ73695727
Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTENQ73708485
Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T-cell lymphomaQ73867868
Treatment of patients with advanced mycosis fungoides and Sézary syndrome with alemtuzumabQ73888073
Evaluation of a new paraffin-reactive CD7 T-cell deletion marker and a polymerase chain reaction-based T-cell receptor gene rearrangement assay: implications for diagnosis of mycosis fungoides in community clinical practiceQ74395643
Levels of expression of CD52 in normal and leukemic B and T cells: correlation with in vivo therapeutic responses to Campath-1HQ74566806
Treatment of cutaneous T-cell lymphoma with combined immunomodulatory therapy: a 14-year experience at a single institutionQ74581707
Total skin electron radiation in the management of mycosis fungoides: Consensus of the European Organization for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Project GroupQ74662041
The use of anti-T-cell receptor-Vbeta antibodies for the estimation of treatment success and phenotypic characterization of clonal T-cell populations in cutaneous T-cell lymphomasQ74673987
Prognostic factors in Sézary syndrome: a multivariate analysis of clinical, haematological and immunological featuresQ77467831
Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cellsQ77720703
Mycosis fungoides: HLA class II associations among Ashkenazi and non-Ashkenazi Jewish patientsQ77779507
The growth of cutaneous T-cell lymphoma is stimulated by immature dendritic cellsQ77869971
Lymphocytes treated by extracorporeal photopheresis demonstrate a drop in the Bcl-2/Bax ratio: a possible mechanism involved in extracorporeal-photopheresis-induced apoptosisQ77893033
Low dose interferon-alpha2b combined with PUVA is an effective treatment of early stage mycosis fungoides: results of a multicenter study. Cutaneous-T Cell Lymphoma Multicenter Study GroupQ78224327
Sézary syndrome patients demonstrate a defect in dendritic cell populations: effects of CD40 ligand and treatment with GM-CSF on dendritic cell numbers and the production of cytokinesQ78385822
Sezary's syndromeQ78832629
Sezary syndrome--a malignant reticulemic erythrodermaQ79079984
Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphomaQ79734221
TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization ofQ79880342
Results of a phase II trial of oral bexarotene (Targretin) combined with interferon alfa-2b (Intron-A) for patients with cutaneous T-cell lymphomaQ79967580
CD158k/KIR3DL2 is a useful marker for identifying neoplastic T-cells in Sézary syndrome by flow cytometryQ80152396
Absolute lymphocyte count predicts therapeutic efficacy of rituximab therapy in follicular lymphomasQ80155795
Extracorporeal photopheresis in combination with bexarotene in the treatment of mycosis fungoides and Sézary syndromeQ80216575
Transimmunization for cutaneous T cell lymphoma: a Phase I studyQ80243086
Pegylated liposomal doxorubicin in the treatment of primary cutaneous T-cell lymphomasQ80292668
Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sézary syndrome: circumvention by hexameric soluble CD40LQ80464383
Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphomaQ35849529
Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapyQ35876581
Deoxycoformycin in the treatment of mature T-cell leukaemiasQ35993316
Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1Q36017473
Electrocardiographic effects of class 1 selective histone deacetylase inhibitor romidepsinQ36023863
Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients.Q36026719
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcomeQ36059635
Cutting Edge: Resident Memory CD8 T Cells Express High-Affinity TCRsQ36119414
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell linesQ36239779
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.Q36258039
Spectrum of infection, risk and recommendations for prophylaxis and screening among patients with lymphoproliferative disorders treated with alemtuzumab*.Q36349776
Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".Q36362764
CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skinQ36370073
Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphomaQ36370759
EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome.Q36436109
Extracorporeal photopheresis: a focus on apoptosis and cytokinesQ36517592
Minimizing adverse side-effects of oral bexarotene in cutaneous T-cell lymphoma: an expert opinionQ36553825
P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228Q36621938
Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphomaQ36726860
Incidence of TCR and TCL1 gene translocations and isochromosome 7q in peripheral T-cell lymphomas using fluorescence in situ hybridization.Q36762171
MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitorQ36850845
Cutaneous T-cell lymphoid dyscrasia: a unifying term for idiopathic chronic dermatoses with persistent T-cell clonesQ36885741
Environmental risk factors for mycosis fungoidesQ36886924
Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes.Q36982497
Haematopoietic stem cell transplantation for patients with primary cutaneous T-cell lymphomaQ37051049
Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomasQ37130122
Review of the treatment of mycosis fungoides and sézary syndrome: a stage-based approachQ37146595
Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 casesQ37201934
Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphomaQ37237464
B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders.Q37348263
Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells.Q37373035
Phase II Investigator-Initiated Study of Brentuximab Vedotin in Mycosis Fungoides and Sézary Syndrome With Variable CD30 Expression Level: A Multi-Institution Collaborative ProjectQ37384289
Pralatrexate, a new hope for aggressive T-cell lymphomas?Q37452226
Gemcitabine treatment in cutaneous T-cell lymphoma: a multicentre study of 23 casesQ42171092
The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.Q42259563
Long-term follow-up in 51 patients with mycosis fungoides and Sézary syndrome treated by interferon-alfaQ42471736
Infrequent Fas mutations but no Bax or p53 mutations in early mycosis fungoides: a possible mechanism for the accumulation of malignant T lymphocytes in the skinQ42522243
Results of an open-label multicenter phase 2 trial of lenalidomide monotherapy in refractory mycosis fungoides and Sézary syndromeQ42633099
Survival outcomes and prognostic factors in mycosis fungoides/Sézary syndrome: validation of the revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer staging proposal.Q42882402
Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphomaQ42942114
Lymphopenia assessed during routine follow-up after immunochemotherapy (R-CHOP) is a risk factor for predicting relapse in patients with diffuse large B-cell lymphomaQ43059183
Gemcitabine as single agent in pretreated T-cell lymphoma patients: evaluation of the long-term outcome.Q43249154
Aberrant Cytokine Production By Sezary Syndrome Patients: Cytokine Secretion Pattern Resembles Murine Th2 CellsQ43434803
Identification of key regions and genes important in the pathogenesis of sezary syndrome by combining genomic and expression microarraysQ43507727
Morphologic and functional properties of the atypical T lymphocytes of the Sezary syndrome.Q43521060
Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial resultsQ43594172
A case-control study of possible causative factors in mycosis fungoidesQ43627104
Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action.Q43990098
Hydrochlorothiazide and cutaneous T cell lymphoma: prospective analysis and case seriesQ44210371
Pentostatin in T-cell malignancies--a phase II trial of the EORTC. Leukemia Cooperative GroupQ44373542
Septicemic complications of the cutaneous T-cell lymphomasQ44541983
Phase II study of pentostatin in advanced T-cell lymphoid malignancies: update of an M.D. Anderson Cancer Center seriesQ44723870
Successful treatment of chemotherapy-refractory Sézary syndrome with alemtuzumab (Campath-1H).Q44763724
Management of refractory early-stage cutaneous T-cell lymphoma (mycosis fungoides) with a combination of oral bexarotene and psoralen plus ultraviolet bath therapyQ44779593
Experience with total skin electron beam therapy in combination with extracorporeal photopheresis in the management of patients with erythrodermic (T4) mycosis fungoidesQ44790858
Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformationQ44827099
A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomasQ44834795
Histologic assessment of lymph nodes in mycosis fungoides/Sézary syndrome (cutaneous T-cell lymphoma): clinical correlations and prognostic import of a new classification systemQ45008356
Cytogenetic, cytophotometric, and ultrastructural study of large cerebriform cells of the Sézary syndrome and description of a small-cell variantQ45233042
Allogeneic hematopoietic cell transplantation for patients with mycosis fungoides and Sézary syndrome: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation.Q45886829
Low-dose methotrexate for the Sézary syndrome.Q45946736
Bexarotene therapy for mycosis fungoides and Sézary syndrome.Q46119707
Identification of tyrosine kinase, HCK, and tumor suppressor, BIN1, as potential mediators of AHI-1 oncogene in primary and transformed CTCL cellsQ46124722
Long-Term Complete Responses to Combination Therapies and Allogeneic Stem Cell Transplants in Patients With Sézary SyndromeQ46148002
Absolute lymphocyte count at the time of first relapse predicts survival in patients with diffuse large B-cell lymphomaQ46175116
Reduction of regulatory T cells by Mogamulizumab, a defucosylated anti-CC chemokine receptor 4 antibody, in patients with aggressive/refractory mycosis fungoides and Sézary syndromeQ46185753
Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphomaQ46207594
Downregulation of Fas gene expression in Sézary syndrome is associated with promoter hypermethylationQ46434131
T-cell clonality analysis in biopsy specimens from two different skin sites shows high specificity in the diagnosis of patients with suggested mycosis fungoidesQ46508858
Prospective multicenter study of pegylated liposomal doxorubicin treatment in patients with advanced or refractory mycosis fungoides or Sézary syndromeQ46535550
Infections Complicating Mycosis Fungoides and Sézary SyndromeQ46649604
Gemcitabine as frontline treatment for cutaneous T-cell lymphoma: phase II study of 32 patientsQ46744850
Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphomaQ46970940
Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).Q46988409
Clonal T-cell populations and increased risk for cytotoxic T-cell lymphomas in B-CLL patients: clinicopathologic observations and molecular analysisQ47272487
In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3.Q47609542
Transformation of mycosis fungoides/Sezary syndrome: clinical characteristics and prognosisQ47725371
CD158k/KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome.Q47758296
Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphomaQ47800148
Flow cytometric assessment of TCR-Vbeta expression in the evaluation of peripheral blood involvement by T-cell lymphoproliferative disorders: a comparison with conventional T-cell immunophenotyping and molecular genetic techniquesQ47947888
Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-cc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma.Q50477276
Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002.Q51103802
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)151-165
P577publication date2015-11-26
P1433published inAmerican Journal of HematologyQ4744246
P1476titleCutaneous T-cell lymphoma: 2016 update on diagnosis, risk-stratification, and management
P478volume91

Reverse relations

cites work (P2860)
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Q47836540AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair
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