Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes.

scientific article published on August 2008

Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.181.4.2506
P932PMC publication ID2586884
P698PubMed publication ID18684941
P5875ResearchGate publication ID23153886

P50authorAnders WoetmannQ38318495
Michal MarzecQ39065406
Xiaobin LiuQ87165894
Mariusz A WasikQ87224772
P2093author name stringMichael Milone
Qian Zhang
John K Choi
Monika Kasprzycka
Agnieszka Witkiewicz
Alain H Rook
Niels Odum
Samik Basu
Eric Vonderheid
Magdalena Potoczek
Joanne Mauger
Hong Yi Wang
J Todd Abrams
J Steven Hou
P2860cites workStat5 is required for IL-2-induced cell cycle progression of peripheral T cellsQ22009002
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte functionQ24290522
FOXP3 controls regulatory T cell function through cooperation with NFATQ24298179
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1Q24300625
Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiationQ28270256
IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21Q28270764
The STATs of cancer--new molecular targets come of ageQ29614601
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cellsQ34318928
Signal transducer and activator of transcription 5 (STAT5).Q34341424
WHO-EORTC classification for cutaneous lymphomasQ34391006
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell developmentQ34597933
Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3Q34773094
Nonredundant roles for Stat5a/b in directly regulating Foxp3Q35828667
Regulatory T cells and mechanisms of immune system controlQ35852343
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotypeQ36059631
Regulatory T cells and tumor immunityQ36114473
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell linesQ36239779
Cd4+Cd25+ regulatory T cells and their therapeutic potentialQ36366885
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.Q36402501
Future perspectives in the treatment of cutaneous T-cell lymphoma (CTCL).Q36413663
IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes.Q36445869
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine designQ36547207
Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma.Q37052602
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndromeQ37387679
FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survivalQ40090775
Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cellsQ40383822
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivoQ42139164
Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitorQ43948616
Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 InhibitorQ44639305
Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiencyQ46893433
Deacetylase inhibition promotes the generation and function of regulatory T cells.Q46961808
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.Q51998742
A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection.Q55239445
Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cellsQ56903036
Differential regulation of T-cell growth by IL-2 and IL-15Q59748325
IL-21 Enhances Antitumor Responses without Stimulating Proliferation of Malignant T Cells of Patients with Sézary SyndromeQ60711900
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunityQ77995572
IL-2Rbeta links IL-2R signaling with Foxp3 expressionQ80455481
Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cellsQ81326661
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
P304page(s)2506-2512
P577publication date2008-08-01
P1433published inJournal of ImmunologyQ3521441
P1476titleGamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes
P478volume181

Reverse relations

cites work (P2860)
Q51603241Anti-gamma chain and anti-IL-2Rbeta mAbs in combination with donor splenocyte transfusion induce H-Y skin graft acceptance in murine model.
Q45738584Autocrine IL-21 stimulation is involved in the maintenance of constitutive STAT3 activation in Sézary syndrome
Q37139517Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma
Q64235755Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma
Q38909786Bortezomib inhibits expression of TGF-β1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells
Q38714687Cutaneous T cell lymphoma expresses immunosuppressive CD80 (B7-1) cell surface protein in a STAT5-dependent manner
Q27024076Cutaneous T-cell lymphoma: 2014 update on diagnosis, risk-stratification, and management
Q36470196Cutaneous T-cell lymphoma: 2016 update on diagnosis, risk-stratification, and management
Q48034709Cutaneous T-cell lymphoma: 2017 update on diagnosis, risk-stratification, and management.
Q37967108Cutaneous lymphomas: molecular pathways leading to new drugs
Q40531806Expression patterns of the immunosuppressive proteins PD-1/CD279 and PD-L1/CD274 at different stages of cutaneous T-cell lymphoma/mycosis fungoides
Q84278927FOXP3+CD25- tumor cells with regulatory function in Sézary syndrome
Q59050199FoxP3-Positive T-Regulatory Cells in Lymph Nodes with Mycosis Fungoides and Sézary Syndrome
Q36392832Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells
Q33728396IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF).
Q39586865Malignant cutaneous T-cell lymphoma cells express IL-17 utilizing the Jak3/Stat3 signaling pathway
Q37723390Malignant inflammation in cutaneous T-cell lymphoma-a hostile takeover
Q38757938Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma
Q55407685Mycosis fungoides progression could be regulated by microRNAs.
Q38162229NFκB function and regulation in cutaneous T-cell lymphoma
Q37081609Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).
Q35220408Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS
Q37929548Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome.
Q36675064Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma
Q33987080Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation.
Q94503541Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma
Q94686468Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome
Q26746551Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
Q54117760The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL).
Q41573605The histone deacetylase inhibitor romidepsin synergizes with lenalidomide and enhances tumor cell death in T-cell lymphoma cell lines
Q34672100The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.
Q37975058The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma
Q37408217Transcriptional regulation of Foxp3 gene: multiple signal pathways on the road

Search more.