Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe.

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Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe. is …
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scholarly articleQ13442814

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P819ADS bibcode2012PNAS..109E3539D
P356DOI10.1073/PNAS.1218247109
P932PMC publication ID3529049
P698PubMed publication ID23184982
P5875ResearchGate publication ID233775167

P50authorBertil HilleQ202480
Liangyi ChenQ55641102
Joseph G DumanQ74428312
P2093author name stringEamonn J Dickson
Mark W Moody
P2860cites workOrai1 is an essential pore subunit of the CRAC channelQ24300383
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1Q24315782
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel functionQ28305026
Application of Improved Wavelet Transform in Biological Particle Detection*Q58207995
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Role of Ca2+/K+ ion exchange in intracellular storage and release of Ca2+Q59095257
The molecular organization of adrenal chromaffin granulesQ71374039
Signal flows from two phospholipase C-linked receptors are independent in PC12 cellsQ72557655
Mouse mast cell secretory granules can function as intracellular ionic oscillatorsQ28363682
A model for receptor-regulated calcium entryQ29620427
STIMulating store-operated Ca(2+) entryQ30489311
Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overloadQ30581095
Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).Q30950919
Kinetics of PIP2 metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cellsQ33615029
Molecular basis of calcium signaling in lymphocytes: STIM and ORAIQ33819323
Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.Q33881690
ATP-independent luminal oscillations and release of Ca2+ and H+ from mast cell secretory granules: implications for signal transductionQ34182292
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Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cellsQ34430018
Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells.Q34545497
STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human plateletsQ34752168
Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells.Q34763388
Molecular physiology of the SERCA and SPCA pumpsQ35051259
Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury.Q35188746
Local cytosolic Ca2+ elevations are required for stromal interaction molecule 1 (STIM1) de-oligomerization and termination of store-operated Ca2+ entryQ35378683
Local Ca2+ signals in cellular signallingQ35752804
Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera.Q36293994
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedbackQ36411634
Calcium transport mechanisms of PC12 cells.Q36517762
Short pulses of acetylcholine stimulation induce cytosolic Ca2+ signals that are excluded from the nuclear region in pancreatic acinar cellsQ36816532
Evidence that zymogen granules are not a physiologically relevant calcium pool. Defining the distribution of inositol 1,4,5-trisphosphate receptors in pancreatic acinar cellsQ36851752
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensorQ37700695
Role of secretory granules in inositol 1,4,5-trisphosphate-dependent Ca(2+) signaling: from phytoplankton to mammalsQ37822967
Goblet cells secretion and mucogenesisQ37918864
Orai1 and STIM1 are critical for breast tumor cell migration and metastasisQ39888627
Inositol 1,4,5-trisphosphate receptors, secretory granules and secretion in endocrine and neuroendocrine cellsQ40542905
The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factorQ41233302
Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphateQ41791223
Inositol 1,4,5-trisphosphate-triggered Ca2+ release from bovine adrenal medullary secretory vesicles.Q41904431
Ca2+ dynamics in the secretory vesicles of neurosecretory PC12 and INS1 cellsQ42800047
Mechanisms of pH regulation in the regulated secretory pathwayQ43636961
pH-dependent regulation of lysosomal calcium in macrophagesQ43893449
Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).Q44285317
Calcium requirements for exocytosis do not delimit the releasable neuropeptide poolQ44346131
Melanin has a role in Ca2+ homeostasis in human melanocytes.Q44352751
Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.Q44725330
Calcium dynamics in catecholamine-containing secretory vesiclesQ46464274
Recapture after exocytosis causes differential retention of protein in granules of bovine chromaffin cells.Q50796308
P4510describes a project that usesImageJQ1659584
P433issue51
P407language of work or nameEnglishQ1860
P304page(s)E3539-48
P577publication date2012-11-26
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleOrai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe
P478volume109

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cites work (P2860)
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