The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond

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The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1028230392
P356DOI10.1532/IJH97.06011
P698PubMed publication ID16720548

P2093author name stringKazuo Kinoshita
Taichiro Nonaka
P2860cites workBinding of hepatitis C virus to CD81Q22004178
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) geneQ24290122
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)Q24290325
The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNAQ24305266
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Q24307678
Somatic hypermutation of the AID transgene in B and non-B cellsQ24535846
Inflammation and cancerQ24649640
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinQ27860488
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strandQ28190690
Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutationQ28202500
Hypermutation of HIV-1 DNA in the Absence of the Vif ProteinQ28204475
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomasQ28207345
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRILQ28216755
Class-switch recombination: interplay of transcription, DNA deamination and DNA repairQ28269740
Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogrammingQ28284694
Evolution of isotype switchingQ28291304
Activation-induced deaminase: controversies and open questionsQ45236549
Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responsesQ45746898
Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissuesQ45875359
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genesQ47982616
Mutator dynamics in fluctuating environments.Q52043835
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type IIQ73053045
Activation and targeting of immunoglobulin switch recombination by activities induced by EBV infectionQ73242362
Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factorsQ74541253
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cellsQ28509339
In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)Q28584032
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Replication protein A interacts with AID to promote deamination of somatic hypermutation targetsQ31099047
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylationQ33226024
DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylaseQ33837311
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expressionQ33934571
CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.Q33956997
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.Q34147986
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cellsQ34249818
Epstein-Barr virus and cancerQ34297027
Linking class-switch recombination with somatic hypermutationQ34297090
Molecular mechanism of class switch recombination: linkage with somatic hypermutationQ34542246
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombinationQ34807643
EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class SwitchingQ36222552
Immunoglobulin gene diversificationQ36312189
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig lociQ36322298
Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminaseQ36399510
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cellsQ36689901
Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenesQ37356991
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombinationQ37512400
Organization of immunoglobulin heavy chain genes and allelic deletion modelQ37585483
Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathwaysQ38624487
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switchQ40522938
C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Q40627624
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversionQ40750743
Somatic hypermutation of immunoglobulin genesQ40955728
Cloning and expression of the AID gene in the channel catfishQ42623288
Molecular cloning of canine activation-induced cytidine deaminase (AID) cDNA and its expression in normal tissuesQ42630957
AID mutant analyses indicate requirement for class-switch-specific cofactorsQ42798287
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblastsQ42813803
Separate domains of AID are required for somatic hypermutation and class-switch recombinationQ42828095
Constitutive expression of AID leads to tumorigenesisQ42944928
Prevalence of hepatitis C virus infection in patients with lymphoproliferative disordersQ42977087
V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia.Q44083652
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient miceQ44194766
High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemiaQ44315242
Stress-induced mutagenesis in bacteriaQ44459277
Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone.Q44509645
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombinationQ44575368
High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemiaQ44762840
AID is required for c-myc/IgH chromosome translocations in vivoQ45021537
AID is expressed in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas and is not correlated with intraclonal heterogeneity.Q45073113
P433issue3
P304page(s)201-207
P577publication date2006-04-01
P1433published inInternational Journal of HematologyQ6051416
P1476titleThe dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond
P478volume83

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cites work (P2860)
Q46255308A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.
Q37649663AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine
Q84021064Aberrant activation-induced cytidine deaminase expression is associated with mucosal intestinalization in the early stage of gastric cancer
Q39640071Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis
Q46437306Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers
Q46729038Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma
Q35557148Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer
Q36523796Digging deep into "dirty" drugs - modulation of the methylation machinery
Q40150411Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling
Q80078384Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
Q37776353Helicobacter pylori-induced activation-induced cytidine deaminase expression and carcinogenesis
Q37793964Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers
Q46378599Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression
Q34698277Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma

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