A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease

scientific article

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROBIOLAGING.2009.11.021
P932PMC publication ID4724437
P698PubMed publication ID20036034
P5875ResearchGate publication ID40784788

P50authorJohn IoannidisQ6251482
Christine Van BroeckhovenQ2247235
Grzegorz OpalaQ9282013
Christine KleinQ21257320
Alexis BriceQ28468841
Jean-Charles LambertQ30003384
Georgia XiromerisiouQ30089850
Rejko KrügerQ30500739
Karin WirdefeldtQ30500894
Matthew J. FarrerQ37380292
George D. MellickQ37830669
Anna Rita BentivoglioQ38589571
Jessie TheunsQ42757468
Juei-Jueng LinQ89762463
Wataru SatakeQ114416472
Aldo QuattroneQ56862866
Suzanne LesageQ63143379
Zbigniew K WszolekQ64754704
Nobutaka HattoriQ64780524
Thomas GasserQ64856147
Georgios M HadjigeorgiouQ64856631
Peter A SilburnQ64858656
Owen A. RossQ67167640
Demetrius M. MaraganoreQ67217419
Alessandro PrigioneQ67219088
Carlo FerrareseQ67219098
Manu SharmaQ67241550
Timothy LynchQ67415133
Francesa de NigrisQ82343876
Olaf RiessQ83912532
Grazia AnnesiQ83917502
Barbara Jasinska-MygaQ83920460
Hiroyuki TomiyamaQ87283574
P2093author name stringTatsushi Toda
Alexis Elbaz
J Mark Gibson
Eng King Tan
Jan Aasly
Ana Djarmati
Genetic Epidemiology of Parkinson's disease consortium
P2860cites workMutations in the parkin gene cause autosomal recessive juvenile parkinsonismQ24309753
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
High-resolution whole-genome association study of Parkinson disease.Q24535861
Genome-wide association studies for complex traits: consensus, uncertainty and challengesQ24550632
Genes mirror geography within EuropeQ24644872
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant miceQ28208193
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's diseaseQ28257086
Efficiency and power in genetic association studiesQ28278645
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's diseaseQ28568790
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of dataQ28943545
Replicating genotype-phenotype associationsQ29614919
Genomewide association study for susceptibility genes contributing to familial Parkinson diseaseQ30437480
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controlsQ30440991
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international studyQ30539203
Designing candidate gene and genome-wide case-control association studies.Q34267117
PINK1 mutations are associated with sporadic early-onset parkinsonismQ34345883
Validating, augmenting and refining genome-wide association signalsQ34976245
The complex interplay among factors that influence allelic association.Q35634519
Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative studyQ36426250
Uncertainty in heterogeneity estimates in meta-analysesQ36987539
Genetic variation of Omi/HtrA2 and Parkinson's diseaseQ37037500
Calibration of credibility of agnostic genome-wide associationsQ37117080
STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statementQ37314650
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson diseaseQ46233748
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathiesQ46361020
Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson DiseaseQ57977634
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
P304page(s)548.e9-18
P577publication date2009-12-24
P1433published inNeurobiology of AgingQ7002141
P1476titleA large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
P478volume32

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cites work (P2860)
Q35585384Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease
Q33652004Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.
Q37968014Autosomal dominant Parkinsonism: its etiologies and differential diagnoses
Q28074143Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease
Q90719584Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases
Q37872024DNA methylation in neurodegenerative disorders: a missing link between genome and environment?
Q38115298Genetic basis of Parkinson's disease: inheritance, penetrance, and expression
Q94465937Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells
Q83455065Genetic variations of Omi/HTRA2 in Chinese patients with Parkinson's disease
Q37594762Genetics of Parkinson disease and essential tremor
Q54441120HTRA2 variations in Taiwanese Parkinson's disease.
Q30497725Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice
Q28478469Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice
Q38104226Insights into mitochondrial quality control pathways and Parkinson's disease.
Q33364885Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease
Q64932780Mitochondrial HTRA2 Plays a Positive, Protective Role in Dictyostelium discoideum but Is Cytotoxic When Overexpressed.
Q38823556Mitochondrial Quality Control Proteases in Neuronal Welfare
Q55081064Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease.
Q61216195Mitochondrial Serine Protease HTRA2 p.G399S in a Female with Di George Syndrome and Parkinson's Disease
Q38016860Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease
Q58693945Mitochondrial dysfunction in Parkinson's disease
Q35799109Mitochondrial dysfunction in genetic animal models of Parkinson's disease
Q37686252Mitochondrial protein quality control in health and disease
Q37987023Mitochondrial quality control: a matter of life and death for neurons
Q37627534Mutation Analysis of HTRA2 Gene in Chinese Familial Essential Tremor and Familial Parkinson's Disease.
Q50245099Mutations in HTRA2 are not a common cause of familial classic ET.
Q34758274Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
Q35544534Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria.
Q38188556Parkinson's disease: from genetics to clinical practice
Q37547480Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria.
Q58556997The Role of MicroRNAs in Patients with Amyotrophic Lateral Sclerosis
Q38212812The role of FUS gene variants in neurodegenerative diseases
Q34201811Unravelling the role of defective genes

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