Genetically engineered mouse models in cancer research

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Genetically engineered mouse models in cancer research is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0065-230X(10)06004-5
P932PMC publication ID3533445
P698PubMed publication ID20399958

P2093author name stringTerry Van Dyke
Jessica J Hawes
Karlyne M Reilly
Jessica C Walrath
P2860cites workGermline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancerQ21195235
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
The genomes of recombinant inbred linesQ24544739
CRE recombinase-inducible RNA interference mediated by lentiviral vectorsQ24562287
Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vectorQ24563904
Cre-lox-regulated conditional RNA interference from transgenesQ24564248
Targeted oncogene activation by site-specific recombination in transgenic miceQ24564632
Tight control of gene expression in mammalian cells by tetracycline-responsive promotersQ24564850
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approachQ24633776
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrowQ24645717
Efficient tumour formation by single human melanoma cellsQ24648938
The role of NKT cells in tumor immunityQ24648939
A transposon-based genetic screen in mice identifies genes altered in colorectal cancerQ24655169
Mouse xenograft models vs GEM models for human cancer therapeuticsQ24657555
Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiencyQ24800925
The role of transgenic mouse models in carcinogen identificationQ24814156
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.Q27824850
A genetic model for colorectal tumorigenesisQ27860582
Gene expression profiling predicts clinical outcome of breast cancerQ27860732
Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumoursQ71767498
Absence of secretory phospholipase A2 gene alterations in human colorectal cancerQ71804941
Transgenics at breaking-pointQ73466849
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicityQ73552961
Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout miceQ73715124
Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progressionQ74812416
Enhanced tumor formation in mice heterozygous for Blm mutationQ74813290
Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient miceQ78532668
Animal models for disease: knockout, knock-in, and conditional mutant miceQ79330719
Tissue-specific transgenic and knockout miceQ80161443
Coevolution in the tumor microenvironmentQ81174508
The Collaborative Cross, developing a resource for mammalian systems genetics: a status report of the Wellcome Trust cohortQ81390325
Bioluminescence technology for imaging cell proliferationQ81428472
Establishment of "The Gene Mine": a resource for rapid identification of complex trait genesQ81808411
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Cancer predisposition caused by elevated mitotic recombination in Bloom miceQ28139170
Fate of the mammalian cardiac neural crestQ28139176
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisQ28140740
Oncogenic mechanisms of Evi-1 proteinQ28190419
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cellsQ28201183
Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cellsQ28207586
Mouse models for human DNA mismatch-repair gene defectsQ28214396
Transforming pathways activated by the v-Abl tyrosine kinaseQ28217156
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in miceQ28238747
Cross-species oncogenomics in cancer gene identificationQ28249773
Cancer stem cells: mirage or reality?Q28257690
Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formationQ28266922
Second-generation shRNA libraries covering the mouse and human genomesQ28275183
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell linesQ28281211
Mechanisms of gene silencing by double-stranded RNAQ28282560
The epigenomics of cancerQ28289975
Recombineering: a homologous recombination-based method of genetic engineeringQ28307909
The lac operator-repressor system is functional in the mouseQ28366874
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effectsQ28511432
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier systemQ28513603
Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ miceQ28590861
Mouse models of tumor development in neurofibromatosis type 1Q28591083
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumorsQ28592210
Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesisQ28593625
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancerQ29547558
Paradoxical roles of the immune system during cancer developmentQ29614305
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancyQ29614312
A molecular signature of metastasis in primary solid tumorsQ29614442
NF-kappaB functions as a tumour promoter in inflammation-associated cancerQ29614598
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancerQ29614599
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in miceQ29616222
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesisQ29616631
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient miceQ34549869
A method for the generation of conditional gene repair mutations in miceQ34582775
Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of miceQ34588197
PiggyBac transposon-mediated gene transfer in human cellsQ34590383
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouseQ34596182
Maximizing mouse cancer modelsQ34661270
EUCOMM--the European conditional mouse mutagenesis program.Q34707596
Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration.Q34756517
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation developmentQ34786920
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic isletsQ34796756
The mifepristone-inducible gene regulatory system in mouse models of disease and gene therapy.Q34870780
RTCGD: retroviral tagged cancer gene databaseQ34923778
The Centre for Modeling Human Disease Gene Trap resourceQ34934856
Human embryonic stem cells have a unique epigenetic signatureQ35012978
Multiple cross and inbred strain haplotype mapping of complex-trait candidate genesQ35023096
Astrocytes as stem cells: nomenclature, phenotype, and translationQ35133562
10 years of mouse cancer modifier loci: human relevanceQ35156206
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesisQ35198652
Cancer susceptibility in the mouse: genetics, biology and implications for human cancerQ35209979
Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermisQ35551846
Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodiesQ35652113
Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM)Q35663546
New mouse models of cancer: single-cell knockoutsQ35721240
Induced mitotic recombination of p53 in vivoQ35721499
Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic miceQ35745271
Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantagesQ35761435
Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice.Q35782743
DNA repair factors and telomere-chromosome integrity in mammalian cells.Q35783240
Techniques: reporter mice - a new way to look at drug action.Q35785779
Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min miceQ35836870
Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levelsQ35845232
Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas.Q35851152
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancerQ35901185
Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse.Q35921914
Tumorigenesis by slow-transforming retroviruses--an updateQ38012047
Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptorsQ38340343
Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1.Q38501282
Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potentialQ39720663
A microarray-based DNA methylation study of glioblastoma multiformeQ39834071
Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells.Q40025706
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and miceQ40386192
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasQ40424687
A public gene trap resource for mouse functional genomicsQ40550992
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasisQ40602468
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.Q40731052
Somatic activation of the K-ras oncogene causes early onset lung cancer in miceQ40809826
N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomasQ40816926
Retroviral insertional mutagenesis as a strategy to identify cancer genesQ40992682
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cellsQ41161849
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1betaQ41903591
Is metastasis predetermined?Q42342294
Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.Q42724718
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouseQ42812392
Site- and time-specific gene targeting in the mouseQ43591560
Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1.Q43693198
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinibQ43742602
In vivo targeting of tumor endothelial cells by systemic delivery of lentiviral vectors.Q44543288
Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virusQ45828140
Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virusQ45841107
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependentQ46068963
Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1.Q46097041
Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vectorQ46416940
Re-entry into the cell cycle is required for bFGF-induced oligodendroglial dedifferentiation and survival.Q48860208
A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis.Q50605367
BAC rescue: a tool for functional analysis of the mouse genome.Q50677638
Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human disease.Q50794081
Chromosomal translocation engineering to recapitulate primary events of human cancer.Q51155518
Bloom syndrome: a mendelian prototype of somatic mutational disease.Q52222079
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.Q52561781
Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.Q52567811
Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer.Q53344889
Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis.Q53346701
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.Q53356315
Telomere dysfunction provokes regional amplification and deletion in cancer genomes.Q53387305
Tumor spectrum in ARF-deficient mice.Q53423902
Bloom SyndromeQ56482234
The Collaborative Cross, a community resource for the genetic analysis of complex traitsQ56896214
Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis GeneQ57274900
Modeling Chromosomal Translocations Using Conditional Alleles to Recapitulate Initiating Events in Human LeukemiasQ58420381
The invertor knock-in conditional chromosomal translocation mimicQ58420386
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancerQ58420389
An inflammatory linkQ59081065
Re-entry into the cell cycle is required for bFGF-induced oligodendroglial dedifferentiation and survivalQ61799155
Chromosomal Instability and Tumors Promoted by DNA HypomethylationQ63253103
Metastasis results from preexisting variant cells within a malignant tumorQ67602509
Anti-angiogenesis: new concept for therapy of solid tumorsQ70493357
Genetics of variation in HDL cholesterol in humans and miceQ36002032
New approaches for modelling cancer mechanisms in the mouse.Q36004700
Advances in imaging mouse tumour models in vivoQ36004705
Strategies for mapping and cloning quantitative trait genes in rodentsQ36085684
Metastasis predictive signature profiles pre-exist in normal tissuesQ36103292
Tissue-specific and reversible RNA interference in transgenic miceQ36129232
Probing p53 biological functions through the use of genetically engineered mouse modelsQ36204567
Retroviral insertional mutagenesis: past, present and futureQ36318150
Contributions of human tumor xenografts to anticancer drug developmentQ36439483
The inflammatory tumor microenvironment and its impact on cancer developmentQ36455107
Mouse models of human non-small-cell lung cancer: raising the bar.Q36547732
Dissecting cancer pathways and vulnerabilities with RNAiQ36547770
Application and potential limitations of animal models utilized in the development of trastuzumab (Herceptin): a case studyQ36550493
The mighty mouse: genetically engineered mouse models in cancer drug developmentQ36568461
Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospectsQ36602578
Mouse modeling in oncologic preclinical and translational researchQ36603691
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic miceQ36622112
The cancer stem cell hypothesis: a work in progressQ36639832
The mouse as a model for human biology: a resource guide for complex trait analysisQ36685876
Modeling non-random deletions in cancerQ36686264
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networksQ36688585
How is pluripotency determined and maintained?Q36704169
Xenograft models for the preclinical evaluation of new therapies in acute leukemiaQ36799846
A system for Cre-regulated RNA interference in vivoQ36868413
Tumor angiogenesis: cause or consequence of cancer?Q36899936
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.Q36915086
Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors.Q36941057
A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in miceQ36980093
NKT cells in immunoregulation of tumor immunity: a new immunoregulatory axisQ36982958
Tumor stroma and regulation of cancer developmentQ37014752
Quiet as a mouse: dissecting the molecular and genetic basis of hearingQ37087936
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomasQ37098932
Exploiting dendritic cells and natural killer T cells in immunotherapy against malignanciesQ37121291
The use of xenograft models for the selection of cancer treatments with the EGFR as an example.Q37128868
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first centuryQ34423288
An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse modelQ34448414
Harnessing preclinical mouse models to inform human clinical cancer trials.Q34498952
Genetically engineered models have advantages over xenografts for preclinical studiesQ34508688
Neurofibromas in NF1: Schwann cell origin and role of tumor environmentQ34509108
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytomaQ34509145
Cancer modeling in the modern era: progress and challengesQ34520417
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapyQ37143395
Development of a novel mouse glioma model using lentiviral vectorsQ37164106
Inflammation: gearing the journey to cancerQ37166066
Is tumor growth sustained by rare cancer stem cells or dominant clones?Q37179962
Molecular-genetic imaging based on reporter gene expressionQ37181554
Imatinib mesylate for the treatment of chronic myeloid leukemiaQ37183434
Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming.Q37189326
Glioma formation, cancer stem cells, and akt signalingQ37205122
The future of mouse QTL mapping to diagnose disease in mice in the age of whole-genome association studiesQ37256790
VEGF inhibition: insights from preclinical and clinical studiesQ37259271
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.Q37266967
Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteinsQ37267377
Chr 19(A/J) modifies tumor resistance in a sex- and parent-of-origin-specific mannerQ37267802
Alterations of DNA methylation and clinicopathological diversity of human cancersQ37272742
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancersQ37272977
The analysis of metastasis in transgenic mouse modelsQ37323450
Applications of lentiviral vectors for shRNA delivery and transgenesisQ37347170
Genetically engineered mouse models of brain cancer and the promise of preclinical testingQ37348716
The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems geneticsQ37349416
Pharmacogenetics in breast cancer therapyQ37352437
In vivo/ex vivo and in situ assays used in cancer research: a brief reviewQ37355404
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutationsQ37363083
Clonality of mouse and human cardiomyogenesis in vivoQ37385968
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethalityQ37407179
Chromosome engineering in ES cellsQ37407918
An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.Q37486791
High-throughput insertional mutagenesis screens in mice to identify oncogenic networksQ37492234
Target-based therapies in breast cancer: current status and future perspectives.Q37518897
Humanized mice for modeling human infectious disease: challenges, progress, and outlook.Q37555592
Ecdysone-inducible gene expression in mammalian cells and transgenic mice.Q37651825
Antiangiogenic therapy of transgenic mice impairs de novo tumor growthQ37707900
Viral etiology of cancer and leukemia: a look into the past, present and future--G.H.A. Clowes Memorial LectureQ37719008
Systemic spread is an early step in breast cancerQ29617041
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cellsQ29617246
Induction of Tumors in Mice by Genomic HypomethylationQ29618551
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cellsQ29618944
Atm-deficient mice: a paradigm of ataxia telangiectasiaQ29619532
Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus taggingQ29619816
Tumorigenesis and the angiogenic switchQ29619849
Essential role of mouse telomerase in highly proliferative organsQ29620451
Talking about a RevolutionQ30050478
Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco controlQ30485941
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinaseQ30490786
Interaction between bevacizumab and murine VEGF-A: a reassessmentQ30840642
Molecular characterization of the tumor microenvironment in breast cancerQ31095898
Mutagenic insertion and chromosome engineering resource (MICER).Q33204468
Genomewide production of multipurpose alleles for the functional analysis of the mouse genomeQ33214664
Mammalian RNAi: a practical guideQ33222125
Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1.Q33222808
Insights into cancer from transgenic mouse modelsQ33643327
Transformation by v-MybQ33667366
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cellsQ33715154
Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.Q33758222
Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesisQ33834246
Analysing complex genetic traits with chromosome substitution strainsQ33853268
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesisQ33862956
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in miceQ33914498
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cellsQ33938488
Identifying novel genes for atherosclerosis through mouse-human comparative geneticsQ34021005
Recent advances in the protocols of transgenic mouse mutation assays.Q34102919
Inducing cellular dedifferentiation: a potential method for enhancing endogenous regeneration in mammalsQ34151642
Retinoblastoma tumor suppressor and genome stabilityQ34153888
Angiogenesis in transgenic models of multistep carcinogenesisQ34178915
Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivoQ34312741
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasiaQ34313013
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouseQ34344768
Modeling metastasis in vivoQ34347247
Transcription and processing of human microRNA precursorsQ34378218
P304page(s)113-164
P577publication date2010-01-01
P1433published inAdvances in Cancer ResearchQ3113522
P1476titleGenetically engineered mouse models in cancer research
P478volume106

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