Induction of Tumors in Mice by Genomic Hypomethylation

scientific article (publication date: 18 April 2003)

Induction of Tumors in Mice by Genomic Hypomethylation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.1083558
P953full work available at URLhttps://syndication.highwire.org/content/doi/10.1126/science.1083558
P3181OpenCitations bibliographic resource ID57157
P698PubMed publication ID12702876
P5875ResearchGate publication ID10797813

P50authorRudolf JaenischQ90073
P2093author name stringHeinrich Leonhardt
Amir Eden
Joe W. Gray
François Gaudet
Laurie Jackson-Grusby
J. Graeme Hodgson
Jessica Dausman
P2860cites workCancer ResearchQ326097
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase geneQ22011158
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signalsQ22122053
Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityQ28131773
Transcription of IAP endogenous retroviruses is constrained by cytosine methylationQ29618745
Hypomethylation distinguishes genes of some human cancers from their normal counterpartsQ29619217
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stabilityQ29620365
DNA hypomethylation leads to elevated mutation ratesQ34752442
DNA methylation in cancer: too much, but also too littleQ34770545
Reactivating the expression of methylation silenced genes in human cancerQ34770617
Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virusQ34997520
The 5-methylcytosine content of DNA from human tumorsQ35689206
DNA methylation and genetic instability in colorectal cancer cellsQ36049856
Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissuesQ37679466
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repairQ39674490
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulationQ40834659
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesisQ41351086
5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which resultQ41668069
Rearrangement of c-myc, pim-1 and Mlvi-1 and trisomy of chromosome 15 in MCF- and Moloney-MuLV-induced murine T-cell leukemiasQ43821654
Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activationQ45791002
Genome scanning with array CGH delineates regional alterations in mouse islet carcinomasQ46369286
A short DNA methyltransferase isoform restores methylation in vivo.Q50741462
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.Q52201995
Suppression of intestinal neoplasia by DNA hypomethylation.Q54613769
Analysis of early initiating event(s) in radiation-induced thymic lymphomagenesis.Q54968940
The fundamental role of epigenetic events in cancerQ56421597
Chromosomal Instability and Tumors Promoted by DNA HypomethylationQ63253103
X chromosome-linked transmission and expression of retroviral genomes microinjected into mouse zygotesQ71233909
An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndromeQ72228831
Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoterQ77328514
P433issue5618
P407language of work or nameEnglishQ1860
P921main subjectchromosome abnormalityQ744962
DNA methylationQ874745
P304page(s)489-92
P577publication date2003-04-18
P1433published inScienceQ192864
P1476titleInduction of tumors in mice by genomic hypomethylation
Induction of Tumors in Mice by Genomic Hypomethylation
P478volume300

Reverse relations

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Q37962581Genome-wide DNA methylation in human heart failure.
Q28391482Genome-wide analysis in human colorectal cancer cells reveals ischemia-mediated expression of motility genes via DNA hypomethylation
Q64956137Genome-wide hypomethylation of LINE-1 and Alu retroelements in cell-free DNA of blood is an epigenetic biomarker of human aging.
Q35339140Genome-wide methylation profiling of the different stages of hepatitis B virus-related hepatocellular carcinoma development in plasma cell-free DNA reveals potential biomarkers for early detection and high-risk monitoring of hepatocellular carcinoma
Q34122286Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.
Q33242598Genomic alterations in ectopic and eutopic endometria of women with endometriosis
Q38497589Genomic hypomethylation and CpG island hypermethylation in prostatic intraepithelial neoplasm
Q34277089Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome
Q38382440Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes
Q36398297Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women
Q36606069Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer
Q90662533Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability
Q37266816Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.
Q53263685Global DNA hypomethylation coupled to cellular transformation and metastatic ability.
Q34539547Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk
Q48071382Global DNA hypomethylation is associated with the development and poor prognosis of tongue squamous cell carcinoma.
Q64056571Global DNA methylation of peripheral blood leukocytes from dogs bearing multicentric non-Hodgkin lymphomas and healthy dogs: A comparative study
Q34142428Global analysis of DNA methylation in early-stage liver fibrosis
Q54287191Global demethylation in loss of imprinting subtype of Wilms tumor.
Q33519525Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in increased tumorigenicity
Q37962571Global epigenetic profiling in bladder cancer.
Q81007919Global increase in DNA methylation in patients with myelodysplastic syndrome
Q90705372Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner
Q24564106Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
Q35788928Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
Q38175087Harnessing the potential of epigenetic therapy to target solid tumors.
Q92189808Helicase Lymphoid-Specific Enzyme Contributes to the Maintenance of Methylation of SST1 Pericentromeric Repeats That Are Frequently Demethylated in Colon Cancer and Associate with Genomic Damage
Q38484630High resolution integrative analysis reveals widespread genetic and epigenetic changes after chronic in-vitro acid and bile exposure in Barrett's epithelium cells
Q36423456High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer
Q28513000Histone H3-K9 methyltransferase ESET is essential for early development
Q37331641Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice
Q40022345Holocarboxylase synthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events
Q42551273Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats
Q28661652Human GMDS gene fragment hypermethylation in chronic high level of arsenic exposure with and without arsenic induced cancer
Q27010001Human transposon tectonics
Q40136348Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors).
Q24305082Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer
Q37446488Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis
Q37961724Hypomethylation of repeated DNA sequences in cancer.
Q39977133Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype
Q91584734Identification of core differentially methylated genes in glioma
Q34181789Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
Q28238147Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling
Q38335531Identification of novel Myc target genes with a potential role in lymphomagenesis
Q58101947Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: a case-control study
Q36386448Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes.
Q55262096Impact of LINE-1 hypomethylation on the clinicopathological and molecular features of colorectal cancer patients.
Q33996334Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components
Q24306181Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Q33914622In vivo transcriptional regulation of N-Myc target genes is controlled by E-box methylation
Q40448471Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization.
Q37812563Induced pluripotent cancer cells: progress and application
Q26801711Induced pluripotent stem cell technology for dissecting the cancer epigenome
Q35571293Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.
Q39709698Insights into the role of DNA methylation in disease through the use of mouse models
Q36001915Insufficient DNA methylation affects healthy aging and promotes age-related health problems
Q48375750Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures.
Q35919690Integrated analysis of gene expression and DNA methylation changes induced by hepatocyte growth factor in human hepatocytes
Q90705746Integrated genomic and methylation profile analysis to identify candidate tumor marker genes in patients with colorectal cancer
Q28077579Integrating Epigenomics into the Understanding of Biomedical Insight
Q36152246Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer
Q37550690Interaction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300.
Q24658370Intra-individual change over time in DNA methylation with familial clustering
Q38715367Intragenic DNA methylation prevents spurious transcription initiation
Q36854908Intratumoral Heterogeneity of the Epigenome.
Q58753393Ionizing Radiation and Human Health: Reviewing Models of Exposure and Mechanisms of Cellular Damage. An Epigenetic Perspective
Q82799816Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo
Q39233074Is DNA methylation the new guardian of the genome?
Q39805891Isolation of cancer-specific chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter
Q35839338Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle.
Q24799489L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas
Q42908408LINE-1 activation and epigenetic silencing of suppressor genes in cancer: Causally related events?
Q33886421LINE-1 hypomethylation during primary colon cancer progression
Q33283510LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
Q37298707LINE-1 hypomethylation in gastric cancer, detected by bisulfite pyrosequencing, is associated with poor prognosis
Q54302136LINE-1 hypomethylation in noncancerous esophageal mucosae is associated with smoking history.
Q37070832LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Q33550560LINE-1 methylation difference between ameloblastoma and keratocystic odontogenic tumor
Q41699788LINE-1 methylation level and patient prognosis in a database of 208 hepatocellular carcinomas
Q39325725LINE-1 methylation level and prognosis in pancreas cancer: pyrosequencing technology and literature review
Q34294473LINE-1 methylation status and its association with tetralogy of fallot in infants
Q53345314Lack of correlation between DNA copy number and mRNA expression levels of c-myc in gamma-radiation-induced mouse thymic lymphomas by using quantitative real-time PCR.
Q42960321Lack of evidence for green tea polyphenols as DNA methylation inhibitors in murine prostate
Q42186756Large-scale structure of genomic methylation patterns
Q37079680Line region hypomethylation is associated with lifestyle and differs by human papillomavirus status in head and neck squamous cell carcinomas.
Q36001900Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications
Q44885739Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.
Q53110472Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
Q28589092Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis
Q36064770Low-level environmental cadmium exposure is associated with DNA hypomethylation in Argentinean women
Q28505283Lsh is involved in de novo methylation of DNA
Q24297439MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents
Q31150120MBD2 deficiency does not accelerate p53 mediated lymphomagenesis
Q81672675MLL methylation is not likely a common mechanism for therapy-related AML
Q24810367MSRE-PCR for analysis of gene-specific DNA methylation
Q38747872Marked for death: targeting epigenetic changes in cancer
Q92634851Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart
Q34611930Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype
Q36671608MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status
Q41968239Mechanism and clinical significance of cyclooxygenase-2 expression in gastric cancer
Q36803783Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer
Q26861785Mechanisms of epigenetic regulation of leukemia onset and progression
Q35945177Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
Q73456178Meddling with methylation
Q33847875Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation
Q37620965Methods for genome-wide analysis of DNA methylation in intestinal tumors
Q33893167Methods in DNA methylation profiling
Q35169101Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.
Q36913739Methylated DNA and microRNA in body fluids as biomarkers for cancer detection.
Q36891370Methylated DNA sequences for early cancer detection, molecular classification and chemotherapy response prediction
Q64227434Methylation and ovarian cancer: Can DNA methylation be of diagnostic use?
Q58695648Methylation deregulation of miRNA promoters identifies miR124-2 as a survival biomarker in Breast Cancer in very young women
Q37040644Methylation levels of LINE-1 in primary lesion and matched metastatic lesions of colorectal cancer
Q52895027Methylation of the Tumor Suppressor Genes HIC1 and RassF1A Clusters Independently From the Methylation of Polycomb Target Genes in Colon Cancer.
Q40019764Methylation perturbations in retroelements within the genome of a Mus interspecific hybrid correlate with double minute chromosome formation.
Q36076351Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma
Q36076356Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis
Q24795636Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
Q47323579Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis
Q80805160Methylation-sensitive single-nucleotide primer extension (Ms-SNuPE) for quantitative measurement of DNA methylation
Q35208036Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance
Q37238372MiRNAs, epigenetics, and cancer
Q38306947MicroRNA regulatory networks in idiopathic pulmonary fibrosis.
Q30988873Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors
Q33267829Mining methylation for early detection of common cancers
Q31081839Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells
Q28259737Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients
Q34621450Modifiers of epigenetic reprogramming show paternal effects in the mouse.
Q34790860Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study
Q53612758Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation.
Q60955182Molecular Mechanisms Underlying the Link between Diet and DNA Methylation
Q38133084Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine
Q37533620Molecular epigenetics and genetics in neuro-oncology
Q37702543Molecular epigenetics in the management of ovarian cancer: are we investigating a rational clinical promise?
Q38598168Monitoring Dynamics of DNA Methylation at Single-Cell Resolution during Development and Disease
Q35124378Multiple sporadic colorectal cancers display a unique methylation phenotype
Q36628683Multistep carcinogenesis of the colon in Apc(Min/+) mouse
Q45866784Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells
Q54574818Mutations galore in myeloproliferative neoplasms: would the real Spartacus please stand up?
Q38150711Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
Q39069897Mutual regulation of microRNAs and DNA methylation in human cancers
Q36848353Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer
Q35699435Notes on the role of dynamic DNA methylation in mammalian development
Q92890341Novel genes exhibiting DNA methylation alterations in Korean patients with chronic lymphocytic leukaemia: a methyl-CpG-binding domain sequencing study
Q39800607Novel risk markers for gastric cancer screening: Present status and future prospects
Q36617731Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large?
Q53335948Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women.
Q37629350On form and function: does chromatin packing regulate the cell cycle?
Q64078658On the Complexity of Mechanisms and Consequences of Chromothripsis: An Update
Q38020424On the role of retinoblastoma family proteins in the establishment and maintenance of the epigenetic landscape
Q37634314Oncoviruses and Pathogenic MicroRNAs in Humans
Q35867147One-Carbon Metabolism and Colorectal Cancer: Potential Mechanisms of Chemoprevention
Q34016094Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis
Q42107433Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer
Q33356247Optical mapping discerns genome wide DNA methylation profiles
Q39627734Organomegaly and tumors in transgenic mice with targeted expression of HpaII methyltransferase in smooth muscle cells
Q35998526Overexpression of DNA damage-induced 45 α gene contributes to esophageal squamous cell cancer by promoter hypomethylation
Q28554451Overexpression of Ribosomal RNA in the Development of Human Cervical Cancer Is Associated with rDNA Promoter Hypomethylation
Q35620200Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression
Q92351733Paradoxical association of TET loss of function with genome-wide DNA hypomethylation
Q33415064Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity
Q29614515Phenotypic plasticity and the epigenetics of human disease
Q28384560Placental DNA hypomethylation in association with particulate air pollution in early life
Q34955668Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore
Q53212651Point mutation instability (PIN) mutator phenotype as model for true back mutations seen in hereditary tyrosinemia type 1 - a hypothesis.
Q37313424Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy
Q26798810Potential of adipose-derived stem cells in muscular regenerative therapies
Q33525767Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells
Q36109663Predicting the effect of transcription therapy in hematologic malignancies
Q34437941Prediction of methylated CpGs in DNA sequences using a support vector machine
Q36211310Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status
Q64053408Prenatal epigenetics diets play protective roles against environmental pollution
Q48674846Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT).
Q36008593Procainamide is a specific inhibitor of DNA methyltransferase 1.
Q35571288Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg
Q55381984Prognostic value of LINE-1 methylation level in 321 patients with primary liver cancer including hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Q38660226Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells
Q83318087Promoter hypermethylation and global hypomethylation are independent epigenetic events in lymphoid leukemogenesis with opposing effects on clinical outcome
Q36696681Promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin
Q44500993Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia
Q46446472Promoter hypomethylation regulates CD133 expression in human gliomas
Q38895486Promoter-Specific Hypomethylation Is Associated with Overexpression of PLS3, GATA6, and TWIST1 in the Sezary Syndrome.
Q34182555Promoter-dependent mechanism leading to selective hypomethylation within the 5' region of gene MAGE-A1 in tumor cells
Q36535688Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level
Q33864173Proximity ligation in situ assay for monitoring the global DNA methylation in cells
Q36189555RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation
Q28239828RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity
Q51848749RNA-directed epigenomic reprogramming: an emerging principle of a more targeted cancer therapy?
Q36666502Radioadaptive response revisited.
Q36090058Recent advances in molecular diagnosis and therapy of gastric cancer
Q36941312Recreational and household physical activity at different time points and DNA global methylation.
Q33217127Recruitment of DNA methyltransferase I to DNA repair sites
Q27851629Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
Q41841980Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice
Q24536144Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
Q34384312Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.
Q38879235Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation
Q35020444Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice
Q35153140Regulation and function of DNA methylation in plants and animals.
Q37217178Regulation of CpG methylation by Dnmt and Tet in pluripotent stem cells
Q37220124Regulation of pluripotency in male germline stem cells by Dmrt1.
Q38911676Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer.
Q92341929Regulation of transposable elements by DNA modifications
Q41420061Relationship between LINE-1 hypomethylation and Helicobacter pylori infection in gastric mucosae
Q39639045Repeat-element driven activation of proto-oncogenes in human malignancies
Q37119615Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study
Q42931458Replication stress, a source of epigenetic aberrations in cancer?
Q34398115Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus
Q37521263Reprogramming of a melanoma genome by nuclear transplantation
Q28067369Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms
Q26797512Response of transposable elements to environmental stressors
Q24813212Restricted mobility of Dnmt1 in preimplantation embryos: implications for epigenetic reprogramming
Q61759292Retrotransposon-Driven Transcription and Cancer
Q37129860Retrotransposon-encoded reverse transcriptase in the genesis, progression and cellular plasticity of human cancer.
Q38341003Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis
Q38071897Review of the alterations in DNA methylation in esophageal squamous cell carcinoma
Q38895216Rewiring the solid tumor epigenome for cancer therapy
Q37810062Role of epigenetic therapy in myelodysplastic syndrome
Q36459023Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression
Q36155532Role of nuclear architecture in epigenetic alterations in cancer
Q33697456Roles of retrotransposons in benign and malignant hematologic disease
Q39056256Senescent cells harbour features of the cancer epigenome.
Q35916111Sensitive quantitative analysis of murine LINE1 DNA methylation using high resolution melt analysis.
Q34687656Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.
Q28384337Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics
Q33978878Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis
Q50729608Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion.
Q38383972Sodium bisulfite pyrosequencing revealed that developmental exposure to environmental contaminant mixtures does not affect DNA methylation of DNA repeats in Sprague-Dawley rats
Q50504208Soma to germline inheritance of extrachromosomal genetic information via a LINE-1 reverse transcriptase-based mechanism.
Q35694210Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer
Q24657343Specific gene hypomethylation and cancer: new insights into coding region feature trends
Q43152208Specific in vivo expression in type II pneumocytes of the Jaagsiekte sheep retrovirus long terminal repeat in transgenic mice
Q37056726Specific inhibition of one DNMT1-including complex influences tumor initiation and progression.
Q49956187Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma.
Q45866358Stable gene expression occurs from a minority of integrated HIV-1-based vectors: transcriptional silencing is present in the majority
Q37857056Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches.
Q35749932Structure and function of eukaryotic DNA methyltransferases
Q37829700Structure and function of mammalian DNA methyltransferases.
Q47751941Study on the Interaction of the CpG Alternating DNA with CdTe Quantum Dots
Q37301148Superoxide dismutase 1 knockdown induces oxidative stress and DNA methylation loss in the prostate.
Q34563186Suppression of intestinal neoplasia by deletion of Dnmt3b
Q42973524Suppressive effect of global DNA hypomethylation on gastric carcinogenesis
Q38814744Sézary Syndrome: Clinical and Biological Aspects
Q36197509TET proteins and 5-methylcytosine oxidation in hematological cancers
Q89848688TET1 is a Tumor Suppressor That Inhibits Papillary Thyroid Carcinoma Cell Migration and Invasion
Q34445845TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway
Q90429907Targeting DNA Hypomethylation in Malignancy by Epigenetic Therapies
Q36150848Targeting epigenetic regulatory mechanisms in cancer chemoprevention
Q33890546Targeting the epigenome in malignant pleural mesothelioma
Q28511594Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
Q35025083Testing gene function early in the B cell lineage in mb1-cre mice
Q36673761The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium.
Q34772160The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies
Q37029584The Aging Epigenome
Q35702082The Association of LINE-1 Hypomethylation with Age and Centromere Positive Micronuclei in Human Lymphocytes
Q42364239The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
Q33750243The DNA methylome of human peripheral blood mononuclear cells
Q36063358The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation
Q35571262The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease
Q58789495The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting
Q28507079The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin
Q41923596The REMOTE-control system: a system for reversible and tunable control of endogenous gene expression in mice
Q64108233The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome
Q40262798The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation
Q44737509The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine
Q36109310The altered DNA methylation pattern and its implications in liver cancer
Q37911496The application of delivery systems for DNA methyltransferase inhibitors
Q35207554The application of functional genomics to Alzheimer's disease
Q52902095The enemy within: an epigenetic role of retrotransposons in cancer initiation.
Q39021700The epigenetic landscape of renal cancer
Q29617486The epigenetic progenitor origin of human cancer
Q34310378The epigenetics of epithelial-mesenchymal plasticity in cancer
Q36252000The epigenome as a molecular marker and target
Q29617273The history of cancer epigenetics
Q36286073The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases
Q38063931The methylation landscape of tumour metastasis
Q45792913The methylation pattern of p16INK4a gene promoter in psoriatic epidermis and its clinical significance
Q33698033The new field of epigenomics: implications for cancer and other common disease research.
Q33782233The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer
Q37903980The potential role of epigenetic responses to diet in ageing
Q38673415The potential role of retroviruses in autoimmunity
Q44294975The promise of epigenetic therapies in treatment of idiopathic pulmonary fibrosis
Q36955040The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines
Q33911063The regulation of non-coding RNA expression in the liver of mice fed DDC.
Q35589077The rise and fall of genomic methylation in cancer.
Q51205890The role of DNA methylation in ST6Gal1 expression in gliomas.
Q52692099The role of DNA methylation in ageing and cancer.
Q28247253The role of epigenetic inactivation of 14-3-3sigma in human cancer
Q36066276The silence of the genes: epigenetic disturbances in haematopoietic malignancies
Q36943376The stem cell identity of testicular cancer
Q46570903The wayward methyl group and the cascade to cancer
Q24309357Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
Q89634808Tissue and cancer-specific expression of DIEXF is epigenetically mediated by an Alu repeat
Q89076128Tissue-specific DNA methylation loss during ageing and carcinogenesis is linked to chromosome structure, replication timing and cell division rates
Q57239936Towards defining the lymphoma methylome
Q40584357Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1.
Q55260615Transcriptional regulation of metabolism in disease: From transcription factors to epigenetics.
Q99248345Transgenerational inheritance of impaired larval T cell development in zebrafish
Q35840178Transgenic mice as an in vivo model of lymphomagenesis
Q40312232Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells
Q46717074Trapped in action: direct visualization of DNA methyltransferase activity in living cells.
Q35034880Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model.
Q35812510Trials, tribulations, and trends in tumor modeling in mice
Q37688202Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival
Q34169734Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis
Q35795835Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design
Q39637175Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α.
Q37666328Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
Q37632823UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
Q37628934UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma
Q34983911Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma
Q28591019Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1
Q38122355Virion factors that target Daxx to overcome intrinsic immunity.
Q30244255Weight-of-evidence evaluation of associations between particulate matter exposure and biomarkers of lung cancer.
Q34183426Whole genome DNA methylation signature of HER2-positive breast cancer
Q59134234and Methylation Attenuates Tubulin Expression and Cell Stiffness in Cancer
Q24301278p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction

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