Epigenetic linkage of aging, cancer and nutrition

scientific article

Epigenetic linkage of aging, cancer and nutrition is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1242/JEB.107110
P932PMC publication ID4286704
P698PubMed publication ID25568452
P5875ResearchGate publication ID270659864

P50authorTrygve O. TollefsbolQ59697628
P2093author name stringMichael Daniel
P2860cites workA low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in miceQ21092211
Modulation of miRNA expression by dietary polyphenols in apoE deficient mice: a new mechanism of the action of polyphenolsQ21134909
Epigenetic regulation of caloric restriction in agingQ21245250
Crystal structure of the nucleosome core particle at 2.8 A resolutionQ22122355
Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?Q22251049
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseQ24310456
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Q24322196
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA studyQ24598129
RNA and transcriptional modulation of gene expressionQ24605231
MicroRNA let-7: an emerging next-generation cancer therapeuticQ24644251
Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cellsQ24646286
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanismsQ24648759
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cellsQ24648994
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesisQ36958613
Soy isoflavone genistein in prevention and treatment of prostate cancerQ36965664
Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cellsQ36973808
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profileQ37021961
MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatmentQ37039834
FOXO transcription factors in ageing and cancer.Q37048803
Chemoprevention of cancer by isothiocyanates and anthocyanins: mechanisms of action and structure-activity relationship.Q37090062
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanatesQ37130842
Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategyQ37255282
Inflammation and cancer: how friendly is the relationship for cancer patients?Q37316105
Medicinal chemistry of the epigenetic diet and caloric restrictionQ37416325
Effects of caloric restriction on cardiovascular aging in non-human primates and humansQ37452687
Interplay between Epigenetics and Genetics in CancerQ37500876
Targeting the adiponectin:leptin ratio for postmenopausal breast cancer preventionQ37502198
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.Q37533104
Advanced separation methods of food anthocyanins, isoflavones and flavanolsQ37582586
When mutants gain new powers: news from the mutant p53 field.Q37582777
Predictive chromatin signatures in the mammalian genomeQ37609802
Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients.Q37619308
Calories and carcinogenesis: lessons learned from 30 years of calorie restriction researchQ37647283
Non-coding RNAs: identification of cancer-associated microRNAs by gene profilingQ37706520
The pathway from diabetes and obesity to cancer, on the route to targeted therapyQ37788870
Induction of Epigenetic Alterations by Dietary and Other Environmental FactorsQ37798946
Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer.Q37835758
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of TumorigenesisQ37903701
The growing challenge of obesity and cancer: an inflammatory issueQ37906706
The developing, aging neocortex: how genetics and epigenetics influence early developmental patterning and age-related changeQ38054092
Epigenetic effects of natural polyphenols: a focus on SIRT1-mediated mechanismsQ38123766
Genistein modulates oxidative stress in breast cancer cell lines according to ERα/ERβ ratio: effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes.Q39123047
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells.Q39582396
Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell linesQ39697029
Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-kappaB pathway and subsequently downregulating expression of matrix metalloproteinasesQ39704776
Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cellsQ39706990
Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expressionQ39761800
Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression.Q39819560
A dual role of p53 in the control of autophagyQ39964629
p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomeraseQ39995946
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanQ24649811
Caloric restriction delays disease onset and mortality in rhesus monkeysQ24655994
Epigenetics of cervical cancer. An overview and therapeutic perspectivesQ24812104
Dietary epigenetics in cancer and agingQ26858886
MicroRNA, nutrition, and cancer preventionQ27010206
Epigenetic diet: impact on the epigenome and cancerQ27022002
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancerQ27824864
On the Origin of Cancer CellsQ27861025
Chromatin modifications and their functionQ27861067
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanQ28203572
Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cellsQ28237495
Mechanism of human SIRT1 activation by resveratrolQ28238262
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancerQ28239595
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cellsQ28245307
DNA Methylation and Gene FunctionQ28263722
Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedingsQ28264426
Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancerQ28284772
Genetic unmasking of an epigenetically silenced microRNA in human cancer cellsQ28288806
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancersQ28292209
The DNA methyltransferases of mammalsQ29617317
Oxidative stress, caloric restriction, and agingQ29618229
Induction of Tumors in Mice by Genomic HypomethylationQ29618551
Role for DNA methylation in genomic imprintingQ29618669
Hypomethylation distinguishes genes of some human cancers from their normal counterpartsQ29619217
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935Q29620325
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescenceQ29620428
p53 induces distinct epigenetic states at its direct target promotersQ33376888
Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathwaysQ33588231
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancerQ33591673
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegansQ33593407
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell linesQ33631239
Effects of age and caloric restriction on glutathione redox state in miceQ33721622
Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockadeQ33745932
p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanismsQ33842306
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in agingQ33912952
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristicsQ33962085
Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal womenQ36079644
INK4a/ARF: a multifunctional tumor suppressor locusQ36119162
Diet and agingQ36184207
Histone modifications and cancer: biomarkers of prognosis?Q36206499
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shorteningQ36334372
Are sirtuins viable targets for improving healthspan and lifespan?Q36385747
Enhanced histone acetylation and transcription: a dynamic perspectiveQ36555220
Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapyQ36556345
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.Q36572080
Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancerQ36624258
Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factorsQ36729881
Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCGQ36732259
Number of CpG islands and genes in human and mouseQ36738077
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.Q36852678
Introduction: diet, epigenetic events and cancer preventionQ36899303
Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.Q40107103
Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.Q40365994
Effects of caloric restriction in animals on cellular function, oncogene expression, and DNA methylation in vitroQ40385933
Effect of genistein on in vitro and in vivo models of cancerQ40609115
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.Q40614411
Sulforaphane inhibits mitochondrial permeability transition and oxidative stressQ41068183
MicroRNAs 221/222 and Genistein-Mediated Regulation of ARHI Tumor Suppressor Gene in Prostate CancerQ41412852
Does control of mutant p53 by Mdm2 complicate cancer therapy?Q42035568
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemiaQ42053261
Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome.Q42452150
Genistein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: a new mechanism of controlling tumor growthQ43515484
Genome-wide hypomethylation in hepatocellular carcinogenesis.Q43612303
DNA methylation in aging of miceQ44412410
Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samplesQ44488217
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.Q44816904
Genistein induces cell growth inhibition in prostate cancer through the suppression of telomerase activityQ45231438
Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidationQ45288169
Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitisQ46113644
Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells.Q46367447
Histone modification patterns correlate with patient outcome in oral squamous cell carcinomaQ46406967
Serum adiponectin and leptin levels in Taiwanese breast cancer patients.Q46600194
Global DNA hypomethylation in liver cancer cases and controls: a phase I preclinical biomarker development study.Q46886305
Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancerQ47887517
The epigenotype. 1942.Q48429495
Genistein induces growth arrest and suppresses telomerase activity in brain tumor cellsQ48459576
Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression.Q51326502
Serum leptin-adiponectin ratio and endometrial cancer risk in postmenopausal female subjects.Q51393972
Genistein modulates proliferation and mitochondrial functionality in breast cancer cells depending on ERalpha/ERbeta ratio.Q53075798
Increased expression of histone deacetylase 2 is found in human gastric cancer.Q53622619
Growth curves and survival characteristics of the animals used in the Biomarkers of Aging ProgramQ73320329
p16 INK4a can initiate an autonomous senescence programQ73673952
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferasesQ77456357
Caloric restriction and incidence of breast cancerQ79755892
DNA methylation and cancerQ81002014
Cancer incidence in five continents. Volume IXQ83707877
Evaluation of global DNA hypomethylation in human prostate cancer and prostatic intraepithelial neoplasm tissues by immunohistochemistryQ84444815
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.Q33993373
Impact on DNA methylation in cancer prevention and therapy by bioactive dietary componentsQ33996334
Does caloric restriction extend life in wild mice?Q34072413
p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cellsQ34137912
How does calorie restriction work?Q34175282
Regulation of the human catalytic subunit of telomerase (hTERT).Q34180715
Genomic 5-methyldeoxycytidine decreases with age.Q34185566
Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cellsQ34258435
Calorie restriction and cancer prevention: a mechanistic perspectiveQ34258945
Cancer chemoprevention by dietary polyphenols: promising role for epigeneticsQ34279875
DNA methylation in breast cancerQ34304102
Epigenetic control of agingQ34460981
Caloric restriction in primates and relevance to humansQ34497508
Molecular targets of dietary agents for prevention and therapy of cancerQ34505253
Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevityQ34562327
Epigenetics: A New Bridge between Nutrition and HealthQ34591910
Caloric restriction in humansQ34625747
Aging, adiposity, and calorie restrictionQ34653616
Diet and supplements and their impact on colorectal cancerQ34658072
Green tea polyphenol EGCG blunts androgen receptor function in prostate cancerQ34682423
Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span.Q34711105
Impact of Westernization on the nutrition of Japanese: changes in physique, cancer, longevity and centenariansQ34712555
Pathophysiology of ageing.Q34743781
DNA methylation analysis: a powerful new tool for lung cancer diagnosisQ34770585
Cyclooxygenase-2 in human pathological disease.Q35094342
Liver autophagy contributes to the maintenance of blood glucose and amino acid levelsQ35146053
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.Q35207550
Clinical applications of PET in oncologyQ35715365
Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT geneQ35749693
The interaction between FOXO and SIRT1: tipping the balance towards survivalQ35861621
Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesisQ35959363
Mutant p53: one name, many proteinsQ36070574
Calorie restriction, SIRT1 and metabolism: understanding longevityQ36071224
P433issuePt 1
P1104number of pages12
P304page(s)59-70
P577publication date2015-01-01
P1433published inThe Journal of Experimental BiologyQ1355917
P1476titleEpigenetic linkage of aging, cancer and nutrition
P478volume218

Reverse relations

cites work (P2860)
Q48225902(-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression.
Q38690585Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?
Q91628100Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research
Q37265056Contributions of Nonhuman Primates to Research on Aging
Q55191939Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells.
Q58091174Effect of ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells
Q37151868HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
Q36677098Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet.
Q90005574High-resolution genomic alterations in Barrett's metaplasia of patients who progress to esophageal dysplasia and adenocarcinoma
Q64102216Histone Modifications as an Intersection Between Diet and Longevity
Q28822336Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success
Q27016123Impact of Nutrition on Non-Coding RNA Epigenetics in Breast and Gynecological Cancer
Q49833108Impact of dietary patterns and the main food groups on mortality and recurrence in cancer survivors: a systematic review of current epidemiological literature.
Q55374784Importance of Nutrients and Nutrient Metabolism on Human Health.
Q37710116Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes
Q92404330Interaction Among Sex, Aging, and Epigenetic Processes Concerning Visceral Fat, Insulin Resistance, and Dyslipidaemia
Q30251397Islet biology, the CDKN2A/B locus and type 2 diabetes risk
Q47325833Methylation on the Circadian Gene BMAL1 Is Associated with the Effects of a Weight Loss Intervention on Serum Lipid Levels.
Q38536293Mitochondrial responsibility in ageing process: innocent, suspect or guilty
Q49971291Multiplexed and Sensitive DNA Methylation Testing Using Methylation-Sensitive Restriction Enzymes "MSRE-qPCR".
Q36843653Natural Agents Used in Chemoprevention of Aerodigestive and GI Cancers
Q38936974New insights into molecular mechanisms of epigenetic regulation in kidney disease
Q26750817Nutrition, aging and cancer: lessons from dietary intervention studies
Q46107885Overexpression of Histone Deacetylase and Amyloid Precursor Protein in Hepatocellular Carcinoma
Q92807702Sulforaphane - role in aging and neurodegeneration
Q37709114Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro
Q40438865Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans
Q38900826Synthesis, Biological Evaluation, and Computer-Aided Drug Designing of New Derivatives of Hyperactive Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitors
Q90398519Targeting Epigenetic Dependencies in Solid Tumors: Evolutionary Landscape Beyond Germ Layers Origin
Q49885568Tea Polyphenols and Prevention of Epigenetic Aberrations in Cancer
Q42364239The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
Q41537095The Mediterranean Diet Reduces the Risk and Mortality of the Prostate Cancer: A Narrative Review

Search more.