Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α.

scientific article published on November 2010

Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2010.481
P698PubMed publication ID21042279

P50authorUğur ŞahinQ2505089
Özlem TüreciQ92379963
P2093author name stringM Koslowski
U Luxemburger
P2860cites workThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
A conserved family of prolyl-4-hydroxylases that modify HIFQ24291794
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxiaQ24315006
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylationQ24555773
Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb geneQ24595119
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular developmentQ24681396
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1Q28291340
Epigenetics in cancerQ29547853
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau proteinQ29615928
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeuticsQ29615944
Induction of Tumors in Mice by Genomic HypomethylationQ29618551
Loss of Krüppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progressionQ34579406
DNA methylation in cancer: too much, but also too littleQ34770545
Reactivating the expression of methylation silenced genes in human cancerQ34770617
The subtle side to hypoxia inducible factor (HIFalpha) regulationQ35072135
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivoQ36369717
Hypoxia inducible factor-2alpha in cancer.Q36778663
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau proteinQ37286026
Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2.Q37431092
Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissuesQ37679466
Autoregulation of pit-1 gene expression mediated by two cis-active promoter elementsQ38339734
Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2.Q39795314
Effects of DNA methylation on DNA-binding proteins and gene expression.Q40912883
Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding siteQ41027829
DNA methylation: a molecular lockQ41441579
Positive autoregulation of the myogenic determination gene MyoD1.Q44755585
Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody developmentQ45401730
Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues.Q45948325
Frequent nonrandom activation of germ-line genes in human cancer.Q52087806
The human X chromosome is enriched for germline genes expressed in premeiotic germ cells of both sexes.Q53614530
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotypeQ57517773
Chromosomal Instability and Tumors Promoted by DNA HypomethylationQ63253103
Hypomethylation of DNA from benign and malignant human colon neoplasmsQ69381419
EPAS1 trans-activation during hypoxia requires p42/p44 MAPKQ73176153
NFATc1 autoregulation: a crucial step for cell-fate determinationQ80164088
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P1104number of pages7
P304page(s)876-882
P577publication date2010-11-01
P1433published inOncogeneQ1568657
P1476titleTumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α
P478volume30

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cites work (P2860)
Q89181309A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia
Q34782024A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.
Q64096270Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis
Q90398699Berzosertib (VE-822) inhibits gastric cancer cell proliferation via base excision repair system
Q34429865Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions
Q54287944Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation.
Q93012064Differential placental DNA methylation of VEGFA and LEP in small-for-gestational age fetuses with an abnormal cerebroplacental ratio
Q34747263Epigenetic programming of hypoxic-ischemic encephalopathy in response to fetal hypoxia
Q36836974Epigenetic regulation of CD34 and HIF1A expression during the differentiation of human mast cells
Q39490284Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.
Q38084610Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics
Q38096949Epigenetic regulation of hypoxia-responsive gene expression: focusing on chromatin and DNA modifications
Q47651765Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity
Q36573115Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis
Q36395765Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats
Q90633236Gene-Specific Targeting of DNA Methylation in the Mammalian Genome
Q39189766Genetics of the hypoxia-inducible factors in human cancers
Q88540298Gestational Hypoxia and Developmental Plasticity
Q34674453Gestational hypoxia and epigenetic programming of brain development disorders.
Q38968823HIF-1 promotes the expression of its α-subunit via an epigenetically regulated transactivation loop.
Q64099285HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia
Q28505980HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth
Q64086502Hypomethylation at non-CpG/CpG sites in the promoter of HIF-1α gene combined with enhanced H3K9Ac modification contribute to maintain higher HIF-1α expression in breast cancer
Q26767183Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes
Q37943792Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective
Q37694101Non-canonical NFκB mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NFκB pathway.
Q36294979Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells.
Q40844302Probing the epigenetic regulation of HIF-1α transcription in developing tissue.
Q37520359Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma
Q48333559Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.
Q35557736Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection
Q35892567TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma
Q89575253TFF1 Promotes EMT-Like Changes through an Auto-Induction Mechanism
Q36756817The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma.

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