Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas.

scientific article

Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3324/HAEMATOL.2012.068510
P932PMC publication ID3533660
P698PubMed publication ID22801959
P5875ResearchGate publication ID229156085

P50authorMiguel A. PirisQ37831476
Carmen Blanco-AparicioQ48975692
José Luis Rodríguez-PeraltoQ61937654
Margarita Sanchez-BeatoQ71512307
Esperanza Martin-SanchezQ84043346
P2093author name stringManuela Mollejo
Juan F García
Magdalena B Wozniak
James R Bischoff
Diana Romero
Pablo García-Sanz
Pablo L Ortiz-Romero
Socorro M Rodríguez-Pinilla
Javier Menárguez
Guido Kurz
Luis Lombardía
Lina Odqvist
Fernando González-Palacios
Beatriz Domínguez-González
F Javier Alves
P2860cites workGene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
The PI3K pathway as drug target in human cancerQ24632283
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant miceQ28215433
PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphomaQ28256448
Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reactionQ28292732
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and diseaseQ29547614
Targeting PI3K signalling in cancer: opportunities, challenges and limitationsQ29617685
Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphomaQ33375694
Activity of any class IA PI3K isoform can sustain cell proliferation and survival.Q33952917
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signalsQ34184717
New strategies in peripheral T-cell lymphoma: understanding tumor biology and developing novel therapiesQ34683488
The PTEN-PI3K pathway: of feedbacks and cross-talksQ34828662
The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemiaQ34923824
Drugging the PI3 kinome: from chemical tools to drugs in the clinic.Q35622141
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advancesQ36516932
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemiaQ37268926
Molecular classification of T-cell lymphomasQ37398316
Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinasesQ37460004
High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.Q37635287
NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemiaQ37861191
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Present and future of PI3K pathway inhibition in cancer: perspectives and limitationsQ37886008
The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia.Q37953891
PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinicQ38010180
Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphomaQ39336768
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viabilityQ39642145
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.Q39830937
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humansQ41367429
Correlating phosphatidylinositol 3-kinase inhibitor efficacy with signaling pathway status: in silico and biological evaluationsQ43041602
Phosphoinositide 3'-kinase delta: turning off BCR signaling in Chronic Lymphocytic Leukemia..Q43041958
Physiological PTEN expression in peripheral T-cell lymphoma not otherwise specified.Q43103123
Phosphorylated AKT protein is overexpressed in human peripheral T-cell lymphomas and predicts decreased patient survivalQ83380075
Peripheral T-cell lymphomaQ83865733
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)57-64
P577publication date2012-07-16
P1433published inHaematologicaQ5638209
P1476titleSimultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas
P478volume98