Activation of growth hormone receptors by growth hormone and growth hormone antagonist dimers: insights into receptor triggering

scientific article published on 20 December 2007

Activation of growth hormone receptors by growth hormone and growth hormone antagonist dimers: insights into receptor triggering is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/ME.2007-0424
P932PMC publication ID2276467
P698PubMed publication ID18096690
P5875ResearchGate publication ID5751806

P50authorStuart J FrankQ110510716
P2093author name stringJing Jiang
Ning Yang
Xiangdong Wang
Wen Y Chen
John F Langenheim
P2860cites workHuman growth hormone and extracellular domain of its receptor: crystal structure of the complexQ24308045
Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolutionQ24323972
Growth hormone receptor and serum binding protein: purification, cloning and expressionQ24339632
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activationQ27766884
Cell signaling by receptor tyrosine kinasesQ27860474
Protein tyrosine kinase structure and functionQ28145008
Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysisQ28213322
Blockade of growth hormone receptor shedding by a metalloprotease inhibitorQ28266617
Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone moleculeQ28609946
Growth hormone promoted tyrosyl phosphorylation of growth hormone receptors in murine 3T3-F442A fibroblasts and adipocytesQ28609968
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinaseQ28618942
Structural design and molecular evolution of a cytokine receptor superfamilyQ29618154
Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosisQ34075980
Two wrongs can make a right: dimers of prolactin and growth hormone receptor antagonists behave as agonistsQ34451140
Spontaneous heritable changes leading to increased adipose conversion in 3T3 cellsQ34459851
Receptor dimerization in GH and erythropoietin action--it takes two to tango, but how?Q34467387
Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly.Q34953495
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.Q36565214
The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.Q36729032
Determinants of growth hormone receptor down-regulationQ40135075
Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activationQ40141599
Janus kinase 2 influences growth hormone receptor metalloproteolysisQ40312143
Model for growth hormone receptor activation based on subunit rotation within a receptor dimerQ40382202
Janus kinase 2 enhances the stability of the mature growth hormone receptorQ40388582
A conformationally sensitive GHR [growth hormone (GH) receptor] antibody: impact on GH signaling and GHR proteolysisQ40519399
Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerizationQ40919215
JAK2 and STAT5, but not JAK1 and STAT1, Are Required for Prolactin-Induced β-Lactoglobulin TranscriptionQ41102584
Molecular mechanism of growth hormone actionQ41117661
Rational design of potent antagonists to the human growth hormone receptorQ41618965
Direct binding and activation of receptor tyrosine kinases by collagenQ41681111
Autoregulatory mechanisms in protein-tyrosine kinasesQ41758716
Biological activity of bovine placental lactogen in 3T3-F442A preadipocytes is mediated through a somatogenic receptorQ42818565
Growth hormone-dependent tyrosine phosphorylation of a GH receptor-associated high molecular WEIGHT protein immunologically related to JAK2.Q42820459
Physical and functional interaction of growth hormone and insulin-like growth factor-I signaling elementsQ42830324
Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signalingQ42830876
Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signalingQ42833012
Phosphorylation of highly purified growth hormone receptors by a growth hormone receptor-associated tyrosine kinaseQ42834830
Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signalingQ44550669
Treatment of IM-9 cells with human growth hormone (GH) promotes rapid disulfide linkage of the GH receptorQ72019741
Erythropoietin receptor activation by a ligand-induced conformation changeQ78111818
P4510describes a project that usesImageJQ1659584
P433issue4
P304page(s)978-988
P577publication date2007-12-20
P1433published inMolecular EndocrinologyQ3319475
P1476titleActivation of growth hormone receptors by growth hormone and growth hormone antagonist dimers: insights into receptor triggering
P478volume22

Reverse relations

cites work (P2860)
Q38237652A new mechanism for growth hormone receptor activation of JAK2, and implications for related cytokine receptors
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Q34422493Dynamic analysis of GH receptor conformational changes by split luciferase complementation
Q36859543GHR/PRLR Heteromultimer Is Composed of GHR Homodimers and PRLR Homodimers
Q54110794Growth Hormone Receptor Mutations Related to Individual Dwarfism.
Q34712091Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex
Q34054406Human growth hormone: 45-kDa isoform with extraordinarily stable interchain disulfide links has attenuated receptor-binding and cell-proliferative activities
Q35590849Inhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mapping
Q37155400Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1
Q34685444Intracellular signaling transduction pathways triggered by a well-known anti-GHR monoclonal antibody, Mab263, in vitro and in vivo
Q36826553JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells
Q27008904Molecular mechanisms of prolactin and its receptor
Q35755050Osteoblast-restricted Disruption of the Growth Hormone Receptor in Mice Results in Sexually Dimorphic Skeletal Phenotypes
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Q36945222TIMP3 Modulates GHR Abundance and GH Sensitivity
Q61797690Targeting growth hormone function: strategies and therapeutic applications
Q38282715The many faces of prolactin in breast cancer
Q36932552The role of prolactin receptor in GH signaling in breast cancer cells

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