Osteoblast-restricted Disruption of the Growth Hormone Receptor in Mice Results in Sexually Dimorphic Skeletal Phenotypes

scientific article published on 29 March 2013

Osteoblast-restricted Disruption of the Growth Hormone Receptor in Mice Results in Sexually Dimorphic Skeletal Phenotypes is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1018459436
P356DOI10.4248/BR201301006
P932PMC publication ID4472095
P698PubMed publication ID26273494
P5875ResearchGate publication ID236735410

P50authorMary L. BouxseinQ66753654
P2093author name stringDouglas J DiGirolamo
Marie-Claude Faugere
Brian C Goh
Vandana Singhal
P2860cites workDomains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinaseQ24317435
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Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralizationQ74742272
Osteoblast-specific expression of insulin-like growth factor-1 in bone of transgenic mice induces insulin-like growth factor binding protein-5Q81552004
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Pulsatility of growth hormone (GH) signalling in liver cells: role of the JAK-STAT5b pathway in GH actionQ34030528
Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanismsQ34074077
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The role of GH/IGF-I-mediated mechanisms in sex differences in cortical bone size in miceQ34592104
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Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-IQ36232491
Activation of growth hormone receptors by growth hormone and growth hormone antagonist dimers: insights into receptor triggeringQ36512432
Differentiation and proliferation of periosteal osteoblast progenitors are differentially regulated by estrogens and intermittent parathyroid hormone administrationQ36976441
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolismQ37338980
Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcriptionQ38294444
Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone.Q38298544
Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liverQ38309675
Insulin-like growth factor I inhibits the transcription of collagenase 3 in osteoblast culturesQ38342073
Structure and evolution of the growth hormone gene familyQ40151142
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The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3Q41313217
Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcriptionQ41438563
Growth hormone stimulates the tyrosine phosphorylation of 42- and 45-kDa ERK-related proteinsQ41635589
Effects of recombinant human insulin-like growth factor I and II (IGF-I/-II) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cellsQ41653974
Growth hormone (GH) receptors in clonal osteoblast-like cells mediate a mitogenic response to GH.Q41692337
Insulin-like growth factor-I and insulin-like growth factor-II induce c-fos in mouse osteoblastic cellsQ41739461
Interactions between growth hormone, insulin-like growth factor I, and basic fibroblast growth factor in melanocyte growthQ42472027
Insulin receptor substrate-1-mediated enhancement of growth hormone-induced mitogen-activated protein kinase activationQ42492692
Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factorQ42801590
Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblastsQ42820892
Physical and functional interaction of growth hormone and insulin-like growth factor-I signaling elementsQ42830324
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Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes.Q52169941
Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA.Q55037373
Growth hormone binds to a single high affinity receptor site on mouse osteoblasts: modulation by retinoic acid and cell differentiationQ61480407
Expression of functional growth hormone receptors in cultured human osteoblast-like cellsQ61480412
Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated SitesQ61585384
Growth hormone is mitogenic for fetal mouse osteoblasts but not for undifferentiated bone cellsQ68293261
Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathwayQ73222433
Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormoneQ73447619
Insulin-like growth factor I receptor signaling--overlapping or redundant pathways?Q73621905
Multiple extracellular signals promote osteoblast survival and apoptosisQ73635417
Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferationQ73941872
The effects of IGF-I and IGF-II on proliferation and differentiation of human osteoblasts and interactions with growth hormoneQ74501677
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectosteoblastQ917177
sexual dimorphismQ181497
P304page(s)85-97
P577publication date2013-03-29
P1433published inBone researchQ26842189
P1476titleOsteoblast-restricted Disruption of the Growth Hormone Receptor in Mice Results in Sexually Dimorphic Skeletal Phenotypes
P478volume1

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cites work (P2860)
Q36968228Bone and skeletal muscle: neighbors with close ties
Q37628177Combined Effects of Androgen and Growth Hormone on Osteoblast Marker Expression in Mouse C2C12 and MC3T3-E1 Cells Induced by Bone Morphogenetic Protein
Q99614370Effect of growth hormone on insulin signaling
Q34543980Estrogens and Androgens in Skeletal Physiology and Pathophysiology
Q57809722Golgi protein 73 and its diagnostic value in liver diseases
Q54110794Growth Hormone Receptor Mutations Related to Individual Dwarfism.
Q34437537Sex steroid actions in male bone
Q39527508Skeletal effects of growth hormone and insulin-like growth factor-I therapy.

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