Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53.

scientific article published on 16 January 2016

Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS17010122
P8608Fatcat IDrelease_w6rtmirktra3dkezz2szfw2hui
P932PMC publication ID4730363
P698PubMed publication ID26784190
P5875ResearchGate publication ID291170576

P50authorEun Seok KangQ59703034
Bong-Soo ChaQ61196432
P2093author name stringYoung Mi Song
Woo Kyung Lee
Byung-Wan Lee
Yong-Ho Lee
P2860cites workPhosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen speciesQ24305112
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2Q24534641
Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?Q26796638
After the banquet: mitochondrial biogenesis, mitophagy, and cell survivalQ27026657
Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistanceQ28510149
p53 and metabolismQ29617084
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent modelQ34021867
Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease.Q35057592
Hepatokines as a Link between Obesity and Cardiovascular DiseasesQ35126823
Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cellsQ35181450
Pentoxifylline attenuates methionine- and choline-deficient-diet-induced steatohepatitis by suppressing TNF-α expression and endoplasmic reticulum stressQ35738741
Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathwayQ35853068
A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cellsQ36114705
Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction.Q36194777
Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formationQ36452057
The Interplay between Autophagy and AgingQ37275514
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetesQ37612644
Autophagosome formation and molecular mechanism of autophagy.Q37780202
Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation.Q38263220
Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathwayQ38329788
The antioxidant machinery of the endoplasmic reticulum: Protection and signalingQ38368254
Double-edged alliance: mitochondrial surveillance by the UPS and autophagyQ38581881
Glycated albumin causes pancreatic β-cells dysfunction through autophagy dysfunctionQ39148539
Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury.Q41129927
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.Q43186674
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalitiesQ43552270
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heartQ45733826
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
P577publication date2016-01-16
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleMetformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53
P478volume17