Orexin: pathways to obesity resistance?

scientific article published on December 2013

Orexin: pathways to obesity resistance? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11154-013-9259-3
P932PMC publication ID4739824
P698PubMed publication ID24005942
P5875ResearchGate publication ID256449545

P50authorJoshua P NixonQ57334695
P2093author name stringCharles J Billington
Tammy A Butterick
Catherine M Kotz
P2860cites workOrexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorQ24315738
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activityQ24317782
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementiaQ24604133
The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectivesQ24622846
Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716Q28190374
PGC-1alpha: a key regulator of energy metabolismQ28274239
Orexins in the regulation of the hypothalamic-pituitary-adrenal axisQ28299650
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteinsQ28576022
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivatorsQ29617353
Neurons containing hypocretin (orexin) project to multiple neuronal systemsQ29619641
The orexin OX1 receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C.Q30883818
High specificity of human orexin receptors for orexins over neuropeptide Y and other neuropeptidesQ30992148
Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of ratsQ33854221
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolismQ33945163
Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacityQ34072882
Dietary obesity in rats: Body weight and body fat accretion in seven strains of ratsQ34234079
Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protects mice from diet-induced obesity and leads to degenerative lesionsQ34385884
Interindividual variation in posture allocation: possible role in human obesityQ34389514
Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activationQ34390790
Monogenic human obesity syndromesQ48459623
Orexin A mediation of time spent moving in rats: neural mechanisms.Q48483236
Elevated hypothalamic orexin signaling, sensitivity to orexin A, and spontaneous physical activity in obesity-resistant ratsQ48504723
Differential expression of orexin receptors 1 and 2 in the rat brainQ48693654
Central orexin sensitivity, physical activity, and obesity in diet-induced obese and diet-resistant ratsQ48765244
Obesity-prone and -resistant rats differ in their brain [3H]paraminoclonidine bindingQ49052107
OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling.Q51814196
Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins.Q51861344
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.Q53614203
Reduced norepinephrine turnover in organs and brains of obesity-prone rats.Q54180527
Role of nonexercise activity thermogenesis in resistance to fat gain in humans.Q55068194
Heart HIF-1alpha and MAP kinases during hypoxia: are they associated in vivo?Q61835088
Glucose-induced norepinephrine levels and obesity resistanceQ68186320
The response to long-term overfeeding in identical twinsQ68776753
Energy expenditure of nonexercise activityQ73256027
Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in ratsQ73258934
Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cordQ73500580
Selective breeding for diet-induced obesity and resistance in Sprague-Dawley ratsQ73645282
Feeding and activity induced by orexin A in the lateral hypothalamus in ratsQ77601391
Neuroprotective effect of orexin-A is mediated by an increase of hypoxia-inducible factor-1 activity in ratQ83217742
Orexin A in the nucleus accumbens stimulates feeding and locomotor activityQ34429070
Non-exercise activity thermogenesis (NEAT).Q34529581
PGC-1 coactivators in the control of energy metabolismQ34712077
Hypocretins/orexins as integrators of physiological information: lessons from mutant animalsQ34930393
Regulation of neuron mitochondrial biogenesis and relevance to brain healthQ34997535
Orexins and their receptors: structural aspects and role in peripheral tissues.Q35076350
Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulationQ35129455
Spontaneous physical activity protects against fat mass gain.Q35184774
A comparative analysis of the distribution of immunoreactive orexin A and B in the brains of nocturnal and diurnal rodentsQ35878433
PGC-1alpha: turbocharging mitochondriaQ35904070
Chemistry and biology of orexin signalingQ36047054
The neurohormone orexin stimulates hypoxia-inducible factor-1 activityQ36103662
Brain orexin promotes obesity resistance.Q36297727
Behavioral responses to orexin, orexin receptor gene expression, and spontaneous physical activity contribute to individual sensitivity to obesityQ36312461
Orexins: neuropeptides for all seasons and functionsQ36495014
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathwaysQ36510743
Integration of feeding and spontaneous physical activity: role for orexinQ36513380
Neuropeptides controlling energy balance: orexins and neuromedinsQ36531499
High and low activity rats: elevated intrinsic physical activity drives resistance to diet-induced obesity in non-bred ratsQ36724539
Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular diseaseQ36935040
Neuroregulation of nonexercise activity thermogenesis and obesity resistanceQ37045418
Monogenic human obesityQ37071432
Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivityQ37071459
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cellsQ37076957
Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward systemQ37528836
Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley ratsQ38354122
Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell modelQ39314608
The signalling profile of recombinant human orexin-2 receptorQ39965527
MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in miceQ41881288
Dysregulation of hypothalamic serotonin turnover in diet-induced obese ratsQ43894905
Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in ratsQ44680757
Cardiovascular risk factors emerge after artificial selection for low aerobic capacityQ45232068
Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortexQ45248493
NMDA receptor dependent PGC-1alpha up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injuryQ46063105
Deliberate overfeeding in women and men: energy cost and composition of the weight gainQ47207461
Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight changeQ47244308
Distribution of orexin receptor mRNA in the rat brainQ48347303
P433issue4
P921main subjectobesityQ12174
P304page(s)357-364
P577publication date2013-12-01
P1433published inReviews in Endocrine and Metabolic DisordersQ15766899
P1476titleOrexin: pathways to obesity resistance?
P478volume14

Reverse relations

cites work (P2860)
Q38946106Estrogenic suppression of binge-like eating elicited by cyclic food restriction and frustrative-nonreward stress in female rats
Q33693961Mechanisms of body weight fluctuations in Parkinson's disease
Q52664453Microglial Immune Response to Low Concentrations of Combustion-Generated Nanoparticles: An In Vitro Model of Brain Health.
Q37139426Neuroinflammatory and autonomic mechanisms in diabetes and hypertension.
Q28397766Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
Q41493386Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism.
Q38756276Orexin A attenuates palmitic acid-induced hypothalamic cell death
Q47436045Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice
Q39623518Role of orexin A signaling in dietary palmitic acid-activated microglial cells
Q34451399Sleep disorders, obesity, and aging: the role of orexin

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