pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption

scientific article published on 27 February 2008

pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.02713-07
P932PMC publication ID2293062
P698PubMed publication ID18305049

P2093author name stringM Cecchini
J S Mymryk
L M Julian
S Talluri
F A Dick
L A Seifried
P2860cites workMutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteinsQ22253968
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F releaseQ24299116
Chk2 activates E2F-1 in response to DNA damageQ24300634
RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteinsQ24554426
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpointsQ24672780
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressorQ27648933
Retinoblastoma protein recruits histone deacetylase to repress transcriptionQ28262144
Retinoblastoma protein represses transcription by recruiting a histone deacetylaseQ28262155
Rb Interacts with Histone Deacetylase to Repress TranscriptionQ28263985
The regulation of E2F by pRB-family proteinsQ28278789
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylationQ28344288
Sibling rivalry in the E2F familyQ29615056
E2F: a link between the Rb tumor suppressor protein and viral oncoproteinsQ29618375
The E2F transcription factor is a cellular target for the RB proteinQ29620422
Rb targets histone H3 methylation and HP1 to promotersQ29620452
Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domainQ33267341
The release of growth arrest by microinjection of adenovirus E1A DNA.Q33931730
Target gene specificity of E2F and pocket protein family members in living cellsQ33964977
Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteinsQ34340609
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutantQ34356567
Recent lessons in gene expression, cell cycle control, and cell biology from adenovirusQ34469114
The retinoblastoma protein regulates pericentric heterochromatinQ34564813
Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteinsQ36636858
The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.Q36644993
Putting the Oncogenic and Tumor Suppressive Activities of E2F into ContextQ36651851
Adenovirus E1A makes two distinct contacts with the retinoblastoma proteinQ36699252
Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexesQ36826836
Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteinsQ36867565
Differential distribution of the adenovirus E1A proteins and colocalization of E1A with the 70-kilodalton cellular heat shock protein in infected cells.Q36881845
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene productQ37016112
Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexesQ38358560
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exitQ40190904
Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses.Q40471506
pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F ActivitiesQ40629059
p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killingQ41488880
Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexesQ41677093
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activationQ41724590
Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation.Q42474867
The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.Q42648852
Induction of cellular DNA synthesis by purified adenovirus E1A proteinsQ42811224
Identification of the phosphorylation sites in early region 1A proteins of adenovirus type 5 by amino acid sequencing of peptide fragments.Q44225225
Differential regulation of E2F1 apoptotic target genes in response to DNA damage.Q44453757
Identification of a cellular transcription factor involved in E1A trans-activationQ48366187
Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulationQ53525857
Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice.Q53925387
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genesQ54048106
Induction of apoptosis by adenovirus type 5 E1A in rat cells requires a proliferation blockQ64383567
Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene productQ70538968
Tumor induction and tissue atrophy in mice lacking E2F-1Q71129252
E2F-1 functions in mice to promote apoptosis and suppress proliferationQ71129257
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P304page(s)4511-4520
P577publication date2008-02-27
P1433published inJournal of VirologyQ1251128
P1476titlepRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption
P478volume82

Reverse relations

cites work (P2860)
Q40197153A cancer derived mutation in the retinoblastoma gene with a distinct defect for LXCXE dependent interactions
Q39012420A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice
Q27663961An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein
Q37225340Cellular mechanisms of tumour suppression by the retinoblastoma gene.
Q34205875E2F1 mediated apoptosis induced by the DNA damage response is blocked by EBV nuclear antigen 3C in lymphoblastoid cells.
Q27003956Molecular mechanisms underlying RB protein function
Q34985200Opposing oncogenic activities of small DNA tumor virus transforming proteins
Q39986158Rb function is required for E1A-induced S-phase checkpoint activation
Q40700511The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity.
Q35488900The retinoblastoma tumor suppressor promotes efficient human cytomegalovirus lytic replication
Q34774880Viral carcinogenesis: factors inducing DNA damage and virus integration
Q39623471p14(ARF) inhibits the functions of adenovirus E1A oncoprotein.

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