| scholarly article | Q13442814 |
| P356 | DOI | 10.1101/GAD.5.7.1200 |
| P953 | full work available online at | https://syndication.highwire.org/content/doi/10.1101/gad.5.7.1200 |
| P698 | PubMed publication ID | 1829698 |
| P5875 | ResearchGate publication ID | 21325680 |
| P50 | author | Stephen H Devoto | Q59684647 |
| P2093 | author name string | E. Moran | |
| J. R. Nevins | |||
| P. Raychaudhuri | |||
| S. Bagchi | |||
| V. B. Kraus | |||
| P2860 | cites work | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins | Q27861094 |
| Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2 | Q28257603 | ||
| Use of eukaryotic expression technology in the functional analysis of cloned genes | Q29620166 | ||
| Mechanism of transcriptional activation by Sp1: evidence for coactivators | Q29620214 | ||
| Transcription activation by the adenovirus E1a protein | Q29620538 | ||
| A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins | Q33643666 | ||
| E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor | Q33856709 | ||
| Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system | Q33860609 | ||
| Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. | Q34173355 | ||
| Expression of early adenovirus genes requires a viral encoded acidic polypeptide | Q34273788 | ||
| Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins | Q34352327 | ||
| Cellular targets for transformation by the adenovirus E1A proteins | Q34438094 | ||
| Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level | Q36272330 | ||
| Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity | Q36783092 | ||
| Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product | Q36807014 | ||
| The cellular transcription factor E2f requires viral E1A and E4 gene products for increased DNA-binding activity and functions to stimulate adenovirus E2A gene expression | Q36828421 | ||
| Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5. | Q36845795 | ||
| Lytic and transforming functions of individual products of the adenovirus E1A gene. | Q36858951 | ||
| E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related | Q36897529 | ||
| An adenovirus type 5 early gene function regulates expression of other early viral genes | Q37338696 | ||
| Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products | Q37568055 | ||
| An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. | Q37715125 | ||
| A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein | Q38340347 | ||
| Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation | Q38347799 | ||
| A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence | Q38347804 | ||
| Target sequences for cis-acting regulation within the dual promoter of the human c-myc gene | Q40658950 | ||
| Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. | Q41678631 | ||
| Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation | Q41724590 | ||
| Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation | Q42501525 | ||
| The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A. | Q42648852 | ||
| Mechanism of activation of early viral transcription by the adenovirus E1A gene product | Q43950071 | ||
| An adenovirus E1a protein region required for transformation and transcriptional repression | Q44198736 | ||
| Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen | Q53514604 | ||
| Functional domains of adenovirus type 5 E1a proteins | Q53527275 | ||
| An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity | Q64379103 | ||
| DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation | Q64379176 | ||
| Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs | Q64382085 | ||
| The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter | Q69177591 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | genetics | Q7162 |
| transport protein | Q2111029 | ||
| Adenoviridae | Q193447 | ||
| cell cycle proteins | Q76598519 | ||
| P304 | page(s) | 1200-1211 | |
| P577 | publication date | 1991-07-01 | |
| P1433 | published in | Genes & Development | Q1524533 |
| P1476 | title | Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes | |
| P478 | volume | 5 |
| Q77164675 | A Matter of Life and Cell Death |
| Q36676343 | A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoprotein |
| Q24321630 | A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis |
| Q33880827 | Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis |
| Q37375494 | Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo |
| Q36699252 | Adenovirus E1A makes two distinct contacts with the retinoblastoma protein |
| Q24313191 | Adenovirus E1A proteins interact with the cellular YY1 transcription factor |
| Q37016112 | Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product |
| Q30452606 | Adenovirus E1A243 disrupts the ATF/CREB-YY1 complex at the mouse c-fos promoter |
| Q40823566 | Adenovirus-E1A proteins transform cells by sequestering regulatory proteins |
| Q42828076 | Akt is activated in response to an apoptotic signal. |
| Q36765388 | An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription |
| Q36828899 | Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism |
| Q38330343 | Association of cdk2 Kinase with the Transcription Factor E2F During S Phase |
| Q24651154 | Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription |
| Q36824394 | Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex |
| Q40786994 | Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cells |
| Q59795032 | Breaking Bad: How Viruses Subvert the Cell Cycle |
| Q36689847 | Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. |
| Q38218288 | Cell cycle regulation during viral infection |
| Q33769566 | Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site |
| Q36235553 | Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins |
| Q35877660 | Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes |
| Q40038451 | Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters |
| Q40471506 | Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses. |
| Q74452665 | Cooperative Interactions Between RB and p53 Regulate Cell Proliferation, Cell Senescence, and Apoptosis in Human Vascular Smooth Muscle Cells From Atherosclerotic Plaques |
| Q37132604 | Cyclin A, cell cycle control and oncogenesis |
| Q38358560 | Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes |
| Q36817732 | DNA-binding properties of the E1A-associated 300-kilodalton protein |
| Q40015482 | E1A 12S and 13S of the transformation-defective adenovirus type 12 strain CS-1 inactivate proteins of the RB family, permitting transactivation of the E2F-dependent promoter |
| Q36729356 | E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products |
| Q30416673 | E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity |
| Q39723402 | E1A represses apolipoprotein AI enhancer activity in liver cells through a pRb- and CBP-independent pathway |
| Q36694428 | E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins |
| Q38325725 | E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection |
| Q40017841 | E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis |
| Q34381615 | E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP. |
| Q35837977 | E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. |
| Q36560847 | Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1 |
| Q36636493 | Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2 |
| Q35230883 | Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. |
| Q36624943 | Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein |
| Q34113734 | Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus |
| Q37371276 | How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. |
| Q37252945 | Human Cytomegalovirus Can Procure Deoxyribonucleotides for Viral DNA Replication in the Absence of Retinoblastoma Protein Phosphorylation |
| Q39958046 | Human papillomavirus type 45 E7 is a transforming protein inducing retinoblastoma protein degradation and anchorage-independent cell cycle progression. |
| Q36702674 | Identification of a 60-kilodalton Rb-binding protein, RBP60, that allows the Rb-E2F complex to bind DNA. |
| Q28647319 | Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein |
| Q38314507 | Identification of distinct roles for separate E1A domains in disruption of E2F complexes |
| Q36640038 | Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth |
| Q41136752 | Identification of specific amino acid residues of adenovirus 12 E1A involved in transformation and p300 binding |
| Q24652555 | In vivo association of E2F and DP family proteins |
| Q36826836 | Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes |
| Q30311302 | Induction of AP-1 DNA-binding activity and c-fos mRNA by the adenovirus 243R E1A protein and cyclic AMP requires domains necessary for transformation |
| Q38324841 | Induction of E1A-responsive negative factors for transcription of the fibronectin gene in adenovirus E1-transformed rat cells |
| Q36579279 | Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses |
| Q35565369 | Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. |
| Q40872245 | Interactions of the p107 and Rb proteins with E2F during the cell proliferation response |
| Q28286827 | Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor |
| Q36636737 | Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1. |
| Q37634626 | Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation |
| Q36702851 | Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains |
| Q41818217 | Protein Domains Governing Interactions Between E2F, the Retinoblastoma Gene Product, and Human Papillomavirus type 16 E7 Protein |
| Q34138129 | Recessive oncogenes: current status |
| Q36685714 | Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression |
| Q67949579 | Regulation of E2F/cyclin A-containing complex upon retinoic acid-induced differentiation of teratocarcinoma cells |
| Q36233178 | Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts |
| Q37085853 | Regulation of the retinoblastoma proteins by the human herpesviruses. |
| Q40046033 | Repression of RNA polymerase III transcription by adenovirus E1A. |
| Q35934834 | Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein |
| Q42689312 | Sequence and transcription map analysis of early region-1 of porcine adenovirus type-3. |
| Q42491309 | Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators |
| Q24299116 | Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release |
| Q27648933 | Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor |
| Q36551482 | Suppression of mutations in two Saccharomyces cerevisiae genes by the adenovirus E1A protein |
| Q34353737 | Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis |
| Q36816831 | The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α |
| Q39875993 | The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can independently mediate activation of ATF-2. |
| Q29620422 | The E2F transcription factor is a cellular target for the RB protein |
| Q40700511 | The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity. |
| Q53412655 | The paradox of E2F1: oncogene and tumor suppressor gene |
| Q38334818 | The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F |
| Q36566621 | The transcription factor E2F-1 is a downstream target of RB action |
| Q36567610 | The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B. |
| Q40956703 | Trans-activation of cellular genes by hepatitis B virus proteins: a possible mechanism of hepatocarcinogenesis. |
| Q35127707 | Transactivation of Human cdc2 Promoter by Adenovirus E1A |
| Q52899161 | Transactivation of human parvovirus B19 gene expression in endothelial cells by adenoviral helper functions |
| Q36659815 | Transcriptional activation by the adenovirus larger E1a product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1a |
| Q36560772 | Transcriptional repression and growth suppression by the p107 pocket protein |
| Q37373014 | Transforming growth factor beta 1 (TGF beta 1) reduces cellular levels of p34cdc2, and this effect is abrogated by adenovirus independently of the E1A-associated pRB binding activity |
| Q38020415 | Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery. |
| Q41689449 | Viral transactivating proteins |
| Q42638371 | Why should cell biologists study microbial pathogens? |
| Q40771340 | p202, an interferon-inducible negative regulator of cell growth, is a target of the adenovirus E1A protein |
| Q36328385 | p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells |
| Q36540177 | pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption |
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