The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome

scientific article published on August 1997

The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1997PNAS...94.8970G
P356DOI10.1073/PNAS.94.17.8970
P932PMC publication ID22989
P698PubMed publication ID9256419
P5875ResearchGate publication ID13964599

P2093author name stringP M Kloetzel
R Stohwasser
M Groettrup
S Standera
P2860cites workcDNA cloning and interferon gamma down-regulation of proteasomal subunits X and YQ24317539
Newly identified pair of proteasomal subunits regulated reciprocally by interferon gammaQ24322943
Structure and functions of the 20S and 26S proteasomesQ24328777
Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysisQ24561722
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolutionQ27730197
Structure of 20S proteasome from yeast at 2.4 A resolutionQ27735081
Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assemblyQ27931608
A tight cluster of five unrelated human genes on chromosome 16q22.1Q28257685
Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteinsQ28305317
Structure of peptides associated with MHC class I molecules.Q30463852
Proteasome from Thermoplasma acidophilum: a threonine proteaseQ34309062
Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.Q35772675
Sorting out the cytokines of asthmaQ36366166
Generation, translocation, and presentation of MHC class I-restricted peptidesQ40422033
Supply and transport of peptides presented by class I MHC moleculesQ40540071
Peptides naturally presented by MHC class I moleculesQ40898177
Peptide antigen production by the proteasome: complexity provides efficiencyQ41149916
The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitroQ41283840
LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes.Q41320609
Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transportQ41371575
20 S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexesQ41481469
T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell linesQ41529750
The major-histocompatibility-complex-encoded beta-type proteasome subunits LMP2 and LMP7. Evidence that LMP2 and LMP7 are synthesized as proproteins and that cellular levels of both mRNA and LMP-containing 20S proteasomes are differentially regulateQ41533729
Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I moleculesQ41594402
Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybridQ42152736
PRE3, highly homologous to the human major histocompatibility complex-linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl-peptide hydrolyzing activityQ48084093
Altered peptidase and viral-specific T cell response in LMP2 mutant mice.Q52508504
A third interferon-gamma-induced subunit exchange in the 20S proteasome.Q53007185
MHC class I expression in mice lacking the proteasome subunit LMP-7Q57198383
Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunitQ71483389
Incorporation of major histocompatibility complex – encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon‐γQ71815183
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)8970-8975
P577publication date1997-08-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome
P478volume94

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