A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells

scientific article published on 2 February 2016

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.02231-15
P932PMC publication ID4742717
P698PubMed publication ID26838724

P50authorNader PourmandQ88286768
P2093author name stringJohn C Boothroyd
Felice D Kelly
Barry P Sleckman
Jeffrey J Bednarski
Michael W Panas
Magdalena Franco
Nicole D Marino
Kerry R Buchholz
Mei-Chong Wendy Lee
P2860cites workPlasmepsin V licenses Plasmodium proteins for export into the host erythrocyteQ24644157
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Fast gapped-read alignment with Bowtie 2Q27860699
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PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytesQ27972589
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Admixture and recombination among Toxoplasma gondii lineages explain global genome diversityQ28728385
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PTEX is an essential nexus for protein export in malaria parasitesQ30042849
A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosisQ30044533
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.Q33591077
GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune responseQ33602978
Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulenceQ33606893
An aspartyl protease directs malaria effector proteins to the host cellQ33639304
The host targeting motif in exported Plasmodium proteins is cleaved in the parasite endoplasmic reticulum.Q33745481
Toxoplasma secreting Cre recombinase for analysis of host-parasite interactionsQ33774219
Function of the c-Myc oncogenic transcription factor.Q33783511
c-Myc target genes involved in cell growth, apoptosis, and metabolismQ33956988
c-Myc overexpression uncouples DNA replication from mitosisQ33958873
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.Q34121309
Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistanceQ34141696
Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocystsQ34163181
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.Q34501481
Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylationQ34512387
RADIA: RNA and DNA integrated analysis for somatic mutation detectionQ34535183
A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoitesQ34711819
Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasionQ35081695
Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytesQ35121886
Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host responseQ35159661
Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growthQ35202714
Identification of tissue cyst wall components by transcriptome analysis of in vivo and in vitro Toxoplasma gondii bradyzoitesQ35598289
The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole.Q35619266
A patatin-like protein protects Toxoplasma gondii from degradation in a nitric oxide-dependent mannerQ35665371
A genetic screen to isolate Toxoplasma gondii host-cell egress mutantsQ35954119
Dense granules: are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?Q36174886
ToxoDB: an integrated Toxoplasma gondii database resourceQ36454249
The bacterial twin-arginine translocation pathwayQ36498300
An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cellQ36609991
Temporal and spatial distribution of Toxoplasma gondii differentiation into Bradyzoites and tissue cyst formation in vivoQ36804253
The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotationQ36864785
Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15.Q36911407
A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation.Q37194952
Infection by Toxoplasma gondii specifically induces host c-Myc and the genes this pivotal transcription factor regulatesQ37723997
Myc and cell cycle control.Q38202390
Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.Q39163693
The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries.Q40277100
The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.Q40874517
The aspartyl protease TgASP5 mediates the export of the Toxoplasma GRA16 and GRA24 effectors into host cellsQ41054604
Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse.Q50650185
Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit-and-run mutagenesisQ59178755
Role of Oncogenic Transcription Factor c-Myc in Cell Cycle Regulation, Apoptosis and MetabolismQ78391332
Toxoplasma gondii dysregulates IFN-gamma-inducible gene expression in human fibroblasts: insights from a genome-wide transcriptional profilingQ80088037
P2507corrigendum / erratumErratum for Franco et al., "A Novel Secreted Protein, MYR1, Is Central to 's Manipulation of Host Cells"Q57048227
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)e02231-15
P577publication date2016-02-02
P1433published inmBioQ15817061
P1476titleA Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells
P478volume7

Reverse relations

cites work (P2860)
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Q58097217Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii
Q57462284Characterization of a effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation
Q89789642Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the Toxoplasma gondii Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host Cells
Q64085197Congenital Transmission of After Experimental Reinfection With Brazilian Typical Strains in Chronically Infected Sheep
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Q57048227Erratum for Franco et al., "A Novel Secreted Protein, MYR1, Is Central to 's Manipulation of Host Cells"main subjectP921

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