Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma-Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase

scientific article published on 31 July 2019

Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma-Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MSPHERE.00276-19
P932PMC publication ID6669336
P698PubMed publication ID31366709

P50authorMichael W PanasQ89789640
Adit NaorQ59748350
John BoothroydQ59750701
P2093author name stringAbel Ferrel
Hernan A Lorenzi
Elizabeth Tenborg
P2860cites workInverted topology of the Toxoplasma gondii ROP5 rhoptry protein provides new insights into the association of the ROP2 protein family with the parasitophorous vacuole membraneQ80032319
The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2Q91624604
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulenceQ24617053
Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organellesQ24814719
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Q27341809
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activityQ27653416
Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondiiQ27653674
Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptideQ27670931
Fast gapped-read alignment with Bowtie 2Q27860699
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The Sequence Alignment/Map format and SAMtoolsQ27860966
Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasionQ28474820
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiQ28476607
A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteinsQ28481222
The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasitesQ28742887
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3Q29614852
The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modelingQ33259406
Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9.Q33648073
Targeted disruption of the GRA2 locus in Toxoplasma gondii decreases acute virulence in miceQ33761427
Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophagesQ33766719
The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complexQ33828611
The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in miceQ33861156
Toxoplasma gondii ingests and digests host cytosolic proteinsQ34165483
Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.Q34230563
Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responsesQ34238191
Subversion of host cellular functions by the apicomplexan parasitesQ34314006
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.Q34325516
Microneme proteins: structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii.Q34375972
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.Q34501481
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.Q35102296
Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host responseQ35159661
The Toxoplasma gondii rhoptry protein ROP 2 is inserted into the parasitophorous vacuole membrane, surrounding the intracellular parasite, and is exposed to the host cell cytoplasmQ36383023
A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host CellsQ36548282
Rhoptries are major players in Toxoplasma gondii invasion and host cell interactionQ36754832
The Toxoplasma gondii dense granule protein GRA7 is phosphorylated upon invasion and forms an unexpected association with the rhoptry proteins ROP2 and ROP4Q36974474
Rhoptries: an arsenal of secreted virulence factorsQ36998670
Kiss and spit: the dual roles of Toxoplasma rhoptriesQ37024471
Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cellsQ37106751
The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.Q37123452
Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joiningQ37158752
Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ-mediated host defenses.Q37197979
The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondiiQ37904282
Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression.Q38174286
Toxoplasma's ways of manipulating the host transcriptome via secreted effectors.Q38442546
Toxoplasma Effectors Targeting Host Signaling and TranscriptionQ38731005
Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.Q39163693
Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuoleQ39735086
The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries.Q40277100
Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene ExpressionQ40613525
Role of secretory dense granule organelles in the pathogenesis of toxoplasmosisQ41100594
Kinetics and pattern of organelle exocytosis during Toxoplasma gondii/host-cell interaction.Q41582214
Characterization of a family of rhoptry proteins of Toxoplasma gondiiQ43935447
Toxoplasma gondii: characterization and localization of antigens secreted from tachyzoitesQ44479787
The amphipathic alpha helices of the toxoplasma protein GRA2 mediate post-secretory membrane associationQ47847293
Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii.Q48193201
MYR1-Dependent Effectors Are the Major Drivers of a Host Cell's Early Response to Toxoplasma, Including Counteracting MYR1-Independent Effects.Q52333019
Characterization of a effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammationQ57462284
Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1Q64079788
Toxoplasma gondii ROP17 inhibits the innate immune response of HEK293T cells to promote its survivalQ66905238
Exocytosis of Toxoplasma gondii dense granules into the parasitophorous vacuole after host cell invasionQ68566603
Secretion by Toxoplasma gondii of an antigen that appears to become associated with the parasitophorous vacuole membrane upon invasion of the host cellQ69473293
Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblastsQ73478363
P4510describes a project that usesImageJQ1659584
P433issue4
P921main subjectvacuoleQ127702
P577publication date2019-07-31
P1433published inmSphereQ27727104
P1476titleTranslocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma-Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase
P478volume4

Reverse relations

cites work (P2860)
Q93086633A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice
Q89789642Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the Toxoplasma gondii Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host Cells
Q90204174In Vitro Characterization of Protein Effector Export in the Bradyzoite Stage of Toxoplasma gondii
Q92320624Neighbors Working Together: a Toxoplasma Rhoptry Protein That Facilitates Dense Granule Protein Translocation into the Host Cell
Q90403299The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability
Q89789648The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells
Q92094023The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration
Q92668210Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Regulate Maturation of the Cyst Wall

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