Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses

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Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses is …
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scholarly articleQ13442814

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P356DOI10.1016/J.CHOM.2010.07.004
P932PMC publication ID2963626
P698PubMed publication ID20709297
P5875ResearchGate publication ID45650074

P50authorOmar S. HarbQ55153327
Lucia PeixotoQ55979536
David S RoosQ56394669
P2093author name stringFeng Chen
Daniel P Beiting
Paul H Davis
Catie Small Brownback
Dinkorma Ouloguem
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Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondiiQ27653674
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A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cellQ27972747
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The toxoplasma kinase ROP18: an active member of a degenerate familyQ28763605
Dynamics of Toxoplasma gondii differentiationQ30806899
The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modelingQ33259406
ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondiiQ33274196
Reranking candidate gene models with cross-species comparison for improved gene predictionQ33375875
Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in miceQ33415462
Toxoplasma gondii bradyzoites form spontaneously during sporozoite-initiated developmentQ33765729
The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organismsQ33777991
Stage differentiation of the protozoan parasite Toxoplasma gondiiQ33815044
Toxoplasma gondii: transmission, diagnosis and preventionQ34155408
Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondiiQ34432069
The apicoplast: A plastid in Plasmodium falciparum and other apicomplexan parasitesQ34533262
Emerging roles of pseudokinasesQ34552850
Rethinking pseudokinasesQ34590810
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondiiQ34591236
Determination of the genera of cyst-forming coccidiaQ35541176
Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected hostQ36228600
ToxoDB: an integrated Toxoplasma gondii database resourceQ36454249
Rhoptries: an arsenal of secreted virulence factorsQ36998670
Kiss and spit: the dual roles of Toxoplasma rhoptriesQ37024471
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologueQ37087502
Polymorphic secreted kinases are key virulence factors in toxoplasmosisQ37105671
Infection with Toxoplasma gondii results in dysregulation of the host cell cycleQ37109789
The Toxoplasma gondii rhoptry protein ROP4 is secreted into the parasitophorous vacuole and becomes phosphorylated in infected cells.Q37579631
A helical membrane-binding domain targets the Toxoplasma ROP2 family to the parasitophorous vacuoleQ39812575
Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factorQ39954131
Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar spaceQ40289140
The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levelsQ40324186
Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondiiQ40501292
Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cellsQ43569597
Origins, lineage-specific expansions, and multiple losses of tyrosine kinases in eukaryotesQ44159571
Evolution from fish to mammals by gene duplicationQ45239092
Organellar dynamics during the cell cycle of Toxoplasma gondii.Q46645614
Toxoplasma gondii interferes with lipopolysaccharide-induced mitogen-activated protein kinase activation by mechanisms distinct from endotoxin tolerance.Q51024816
Pseudokinases: functional insights gleaned from structure.Q54774270
A genomic perspective of protein kinases in Plasmodium falciparumQ56558814
Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblastsQ73478363
Inverted topology of the Toxoplasma gondii ROP5 rhoptry protein provides new insights into the association of the ROP2 protein family with the parasitophorous vacuole membraneQ80032319
P4510describes a project that useslimmaQ112236343
P433issue2
P304page(s)208-218
P577publication date2010-08-01
P1433published inCell Host & MicrobeQ5058153
P1476titleIntegrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses
P478volume8

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