Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways

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Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1003779
P932PMC publication ID3868521
P698PubMed publication ID24367253
P5875ResearchGate publication ID259457131

P50authorEmily E RosowskiQ83104125
Lindsay JulienQ116996902
Mariane B MeloQ37383772
Daniel AjzenbergQ45878773
Lucy H. YoungQ54259866
Musa A HassanQ57208597
Vincent ButtyQ57208600
Jeroen P SaeijQ67222671
P2093author name stringMarie-Laure Dardé
Ninghan Yang
Quynh P Nguyen
Katherine Fitzgerald
Cynthia Cordeiro
Renée McKell
P2860cites workChanges in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and developmentQ21131617
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Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulenceQ24617053
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and CufflinksQ24633890
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Q27341809
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiQ28476607
Admixture and recombination among Toxoplasma gondii lineages explain global genome diversityQ28728385
Large-scale analysis of the human and mouse transcriptomesQ29547360
DiRE: identifying distant regulatory elements of co-expressed genesQ33335674
Ocular sequelae of congenital toxoplasmosis in Brazil compared with EuropeQ33359609
Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in miceQ33415462
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.Q33591077
Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondiiQ33701574
Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosisQ34012277
Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cellsQ34033603
Strain-dependent host transcriptional responses to Toxoplasma infection are largely conserved in mammalian and avian hostsQ34056304
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Interferon-inducible effector mechanisms in cell-autonomous immunityQ34114819
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.Q34121309
Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responsesQ34238191
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.Q34325516
A module map showing conditional activity of expression modules in cancerQ34353143
Acute lung, heart, liver, and pancreatic involvements with hyponatremia and retinochoroiditis in a 33-year-old French Guianan patientQ34474557
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.Q34501481
Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylationQ34512387
NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells.Q34529550
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondiiQ34591236
Beta interferon suppresses the development of experimental cerebral malariaQ34740075
Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North AmericaQ34843110
Type I interferons increase host susceptibility to Trypanosoma cruzi infectionQ34931909
Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinasesQ35034984
Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulenceQ35035005
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.Q35090382
Toxoplasma gondii effectors are master regulators of the inflammatory responseQ35434828
A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondiiQ35547974
Genetic analysis of the diversity in Toxoplasma gondii.Q35843106
Population structure and mouse-virulence of Toxoplasma gondii in BrazilQ81506276
TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondiiQ83918213
Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineagesQ35889275
Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009)Q35948790
Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosomeQ35973133
Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, BrazilQ36026193
Parasitic central nervous system infections in immunocompromised hostsQ36095864
Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected hostQ36228600
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axisQ36229527
Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondiiQ36396820
Forensic genetics and ethical, legal and social implications beyond the clinicQ36503211
Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infectionQ36611354
Persistent LCMV infection is controlled by blockade of type I interferon signalingQ36808119
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responsesQ36842908
Role of beta interferon in resistance to Toxoplasma gondii infectionQ36968666
In vitro cultivation of Toxoplasma gondii cysts in astrocytes in the presence of gamma interferonQ37030505
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologueQ37087502
Polymorphic secreted kinases are key virulence factors in toxoplasmosisQ37105671
Infection with Toxoplasma gondii results in dysregulation of the host cell cycleQ37109789
Severe acquired toxoplasmosis caused by wild cycle of Toxoplasma gondii, French GuianaQ37164712
Stress-related and spontaneous stage differentiation of Toxoplasma gondii.Q37218715
Innate immunity to virus infection.Q37361448
Regulation of effector and memory T-cell functions by type I interferonQ37841676
Acute toxoplasmoses in immunocompetent patients hospitalized in an intensive care unit in French Guiana.Q38969692
Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.Q39163693
Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferationQ40051388
Beta interferon inhibits Toxoplasma gondii growth in human monocyte-derived macrophages.Q40164692
Host cell invasion by Toxoplasma gondiiQ41712109
Blockade of chronic type I interferon signaling to control persistent LCMV infectionQ41807293
Severe toxoplasmosis caused by a Toxoplasma gondii strain with a new isoenzyme type acquired in French Guyana.Q42777271
TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondiiQ44117743
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasisQ44823542
Protection against progressive leishmaniasis by IFN-beta.Q44928980
Recombinant human IFN-alpha inhibits cerebral malaria and reduces parasite burden in miceQ45027585
Virulent strains of Toxoplasma gondii comprise a single clonal lineageQ46105888
Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathwayQ47810239
Type I interferons suppress CD4⁺ T-cell-dependent parasite control during blood-stage Plasmodium infectionQ47982586
Annual cost of illness and quality-adjusted life year losses in the United States due to 14 foodborne pathogensQ50023108
Unusual abundance of atypical strains associated with human ocular toxoplasmosis.Q52933346
Unresolved questions about the most successful known parasite.Q53158502
Characterization of the factor in L-cell conditioned medium capable of stimulating colony formation by mouse marrow cells in cultureQ56246854
Editorial Commentary: High Burden of Congenital Toxoplasmosis in the United States: The Strain Hypothesis?Q58838824
TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruziQ58845148
Type I IFNs stimulate nitric oxide production and resistance to Trypanosoma cruzi infectionQ58845209
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue12
P304page(s)e1003779
P577publication date2013-12-19
P1433published inPLOS PathogensQ283209
P1476titleTranscriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways
P478volume9

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