Unmethylated CpG motifs in Toxoplasma gondii DNA induce TLR9- and IFN-β-dependent expression of α-defensin-5 in intestinal epithelial cells

scientific article published on 2 November 2015

Unmethylated CpG motifs in Toxoplasma gondii DNA induce TLR9- and IFN-β-dependent expression of α-defensin-5 in intestinal epithelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1017/S0031182015001456
P698PubMed publication ID26522645

P2093author name stringRicardo S Corral
Eugenia Perez Caballero
Miguel H Santamaria
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Parasiticidal activity of human alpha-defensin-5 against Toxoplasma gondiiQ39743175
Lactobacillus johnsonii N6.2 stimulates the innate immune response through Toll-like receptor 9 in Caco-2 cells and increases intestinal crypt Paneth cell number in biobreeding diabetes-prone ratsQ39760916
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Toxoplasma gondii: a rapid method for the isolation of pure tachyzoites. Preliminary characterization of its genomeQ44753157
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Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cellsQ58869398
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Measurement of deoxyguanosine/thymidine ratios in complex mixtures by high-performance liquid chromatography for determination of the mole percentage guanine + cytosine of DNAQ69244081
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Immunostimulatory DNA activates production of type I interferons and interleukin-6 in equine peripheral blood mononuclear cells in vitroQ81849214
Alteration of local microflora and α-defensins hyper-production in colonic adenoma mucosaQ83466615
TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondiiQ83918213
Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysisQ21246026
Reduced Paneth cell alpha-defensins in ileal Crohn's diseaseQ24538724
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DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxideQ34006725
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Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensinQ34186394
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.Q34415669
Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondiiQ34576329
Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tractQ35006270
Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathwaysQ35075096
Beta interferon-mediated activation of signal transducer and activator of transcription protein 1 interferes with Rickettsia conorii replication in human endothelial cellsQ35191945
The immunophysiological impact of bacterial CpG DNA on the gut.Q36253894
Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cellsQ36553535
Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in miceQ36553712
Probing DNA shape and methylation state on a genomic scale with DNase I.Q36782127
Pro-inflammatory and pro-apoptotic properties of Human Defensin 5.Q37087891
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Enteric defensins are essential regulators of intestinal microbial ecologyQ37483232
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P433issue1
P921main subjectToxoplasma gondiiQ131003
toll-like receptorQ408004
P304page(s)60-68
P577publication date2015-11-02
P1433published inParasitologyQ15753259
P1476titleUnmethylated CpG motifs in Toxoplasma gondii DNA induce TLR9- and IFN-β-dependent expression of α-defensin-5 in intestinal epithelial cells
P478volume143

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