Have it your way: how polymorphic, injected kinases and pseudokinases enable Toxoplasma to subvert host defenses

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Have it your way: how polymorphic, injected kinases and pseudokinases enable Toxoplasma to subvert host defenses is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1003296
P932PMC publication ID3635977
P698PubMed publication ID23633947
P5875ResearchGate publication ID236600557

P2093author name stringJohn C Boothroyd
P2860cites workStructures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts.Q24520491
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuoleQ24614550
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulenceQ24617053
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Q27341809
A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteinsQ28481222
ToxoplasmosisQ30080013
Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries.Q30328708
The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modelingQ33259406
Unusual abundance of atypical strains associated with human ocular toxoplasmosis.Q52933346
Toxoplasma gondii Comprises Three Clonal Lineages: Correlation of Parasite Genotype with Human DiseaseQ71829835
Ocular sequelae of congenital toxoplasmosis in Brazil compared with EuropeQ33359609
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.Q33591077
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth controlQ34023014
Strain-dependent host transcriptional responses to Toxoplasma infection are largely conserved in mammalian and avian hostsQ34056304
Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondiiQ34075900
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.Q34121309
Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responsesQ34238191
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.Q34325516
Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondiiQ34432069
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondiiQ34591236
Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinasesQ35034984
Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulenceQ35035005
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.Q35090382
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.Q35102296
Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineagesQ35889275
Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, BrazilQ36026193
The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondiiQ36931641
Kiss and spit: the dual roles of Toxoplasma rhoptriesQ37024471
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologueQ37087502
Polymorphic secreted kinases are key virulence factors in toxoplasmosisQ37105671
A helical membrane-binding domain targets the Toxoplasma ROP2 family to the parasitophorous vacuoleQ39812575
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P304page(s)e1003296
P577publication date2013-04-25
P1433published inPLOS PathogensQ283209
P1476titleHave it your way: how polymorphic, injected kinases and pseudokinases enable Toxoplasma to subvert host defenses
P478volume9