Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells

scientific article published on 19 January 2009

Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20082108
P932PMC publication ID2646567
P698PubMed publication ID19153244
P5875ResearchGate publication ID232594343

P50authorAlan SherQ88390533
P2093author name stringIra Mellman
Isabelle Coppens
Romina S Goldszmid
Pat Caspar
Avital Lev
P2860cites workER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cellsQ28506676
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The role of phospholipase in host cell penetration by Toxoplasma gondii.Q30461287
Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channelQ33912882
Cell biology of antigen processing in vitro and in vivoQ33985828
A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteinsQ34325693
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondiiQ34591236
Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplastQ34767686
The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieveQ34980590
CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomesQ35009488
Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunityQ35099713
Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondiiQ35495758
Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signalingQ36097323
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TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma productionQ36229095
Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cellsQ36313784
Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalizationQ36367948
ToxoDB: an integrated Toxoplasma gondii database resourceQ36454249
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopesQ36633085
Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigensQ36689895
The Toxoplasma gondii parasitophorous vacuole membrane: transactions across the borderQ36735713
Kiss and spit: the dual roles of Toxoplasma rhoptriesQ37024471
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologueQ37087502
Polymorphic secreted kinases are key virulence factors in toxoplasmosisQ37105671
Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum.Q37158031
Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interactionQ38342669
Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuoleQ39735086
Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar spaceQ40289140
On the biogenesis of lipid bodies in ancient eukaryotes: synthesis of triacylglycerols by a Toxoplasma DGAT1-related enzymeQ40500782
Dendritic cells charged with apoptotic tumor cells induce long-lived protective CD4+ and CD8+ T cell immunity against B16 melanomaQ40614114
Quantitating protein synthesis, degradation, and endogenous antigen processingQ40662419
Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondiiQ40997338
Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccineQ41133376
Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblastsQ41725157
Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivoQ41944679
Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathwaysQ42814484
Efficient development of plasmodium liver stage-specific memory CD8+ T cells during the course of blood-stage malarial infectionQ44139710
Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growthQ45263588
Quantitative and dynamic assessment of the contribution of the ER to phagosome formationQ45345589
A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cellsQ45345591
Spatial and mechanistic separation of cross-presentation and endogenous antigen presentationQ46674193
CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major.Q53974457
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectvacuoleQ127702
Toxoplasma gondiiQ131003
dendritic cellQ506253
P304page(s)399-410
P577publication date2009-01-19
P1433published inJournal of Experimental MedicineQ3186912
P1476titleHost ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells
P478volume206

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