Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics

scientific article published on September 2006

Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/DVDY.20890
P698PubMed publication ID16894622
P5875ResearchGate publication ID6891734

P2093author name stringBenoît Robert
Yvan Lallemand
P2860cites workControl of Hoxd genes' collinearity during early limb developmentQ82202978
Axial and paraxial influences on limb morphogenesisQ88980341
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3Q22009022
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limbQ22253250
A global control region defines a chromosomal regulatory landscape containing the HoxD clusterQ24301317
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactylyQ24530593
Proteolytic processing yields two secreted forms of sonic hedgehogQ24652623
Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signalingQ24672542
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactylyQ28184095
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouseQ28204667
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog functionQ28209365
Fibroblast growth factors induce additional limb development from the flank of chick embryosQ28236232
Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh)Q28239036
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 geneQ28263330
Identification of a palmitic acid-modified form of human Sonic hedgehogQ28271228
Resynthesizing evolutionary and developmental biologyQ28276409
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identitiesQ28277481
Morphogens, compartments, and pattern: lessons from drosophila?Q28282905
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb developmentQ28284609
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebratesQ28285927
Retinoic acid is required for the initiation of outgrowth in the chick limb budQ28289746
Cholesterol modification of hedgehog signaling proteins in animal developmentQ28291005
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene functionQ28291924
Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterningQ28504770
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb developmentQ28505407
Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesisQ28506504
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterningQ28507504
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3Q28508067
Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexesQ28508096
Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart developmentQ28508308
Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowthQ28508863
Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndromeQ28509247
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1Q28509262
Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb developmentQ28509748
Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formationQ28586351
Some distal limb structures develop in mice lacking Sonic hedgehog signalingQ28587394
Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expressionQ28588797
Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopodQ28591217
Hedgehog signalling in the mouse requires intraflagellar transport proteinsQ28593010
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cellsQ28609755
Sonic hedgehog mediates the polarizing activity of the ZPAQ29616565
Positional information and the spatial pattern of cellular differentiationQ29616635
Hox genes in digit development and evolutionQ33592049
Fibroblast-growth-factor-induced additional limbs in the study of initiation of limb formation, limb identity, myogenesis, and innervationQ33592062
Engineering the mouse genome by site-specific recombinationQ33744862
Finding the genes that direct mammalian development : ENU mutagenesis in the mouse.Q33846531
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.Q33877368
Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identityQ34146314
Organizing axes in time and space; 25 years of colinear tinkeringQ34215299
Local application of retinoic acid to the limb bond mimics the action of the polarizing regionQ34277958
Finger or toe: the molecular basis of limb identityQ34281744
Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage.Q34297272
A positive feedback loop coordinates growth and patterning in the vertebrate limb.Q34324097
Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligandQ34372957
"Fingering" the vertebrate limbQ34499173
Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathwayQ35096113
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptusQ35915402
The developing limb and the control of the number of digitsQ36023736
Developmental regulation of the Hox genes during axial morphogenesis in the mouseQ36156226
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domainsQ38343320
Interdigital regulation of digit identity and homeotic transformation by modulated BMP signalingQ39542358
The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell deathQ39646720
Site-specific recombinases: tools for genome engineering.Q40721692
The world according to hedgehogQ40915522
Function of homeobox genes in skeletal developmentQ41029846
Developmental functions of mammalian Hox genesQ41547501
Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud developmentQ41734974
The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limbQ44254913
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a RepressorQ44894172
Roles for FGF8 in the induction, initiation, and maintenance of chick limb developmentQ46448253
Eyes absent, a key repressor of polar cell fate during Drosophila oogenesisQ47072399
Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identityQ47176645
A dual role for Hox genes in limb anterior-posterior asymmetryQ47358694
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.Q47719346
Function of BMPs in the apical ectoderm of the developing mouse limbQ47774270
Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signalingQ48279054
Genomic regulation of Hox collinearity.Q52029359
Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function.Q52046374
Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo.Q52054111
Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.Q52059096
Single base pair change in the long-range Sonic hedgehog limb-specific enhancer is a genetic basis for preaxial polydactyly.Q52060924
Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development.Q52088155
The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.Q52088637
Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.Q52095015
Fgf signaling controls the number of phalanges and tip formation in developing digits.Q52099058
Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs.Q52112403
Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development.Q52113875
In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb.Q52115127
Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.Q52115170
Hox9 genes and vertebrate limb specification.Q52195016
Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse.Q52196441
Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls.Q52201020
Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures.Q52215001
Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt)Q57927095
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb budQ58198494
Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formationQ59065602
Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)Q59986797
A duplicated zone of polarizing activity in polydactylous mouse mutantsQ71941033
Limb initiation and development is normal in the absence of the mesonephrosQ73702375
P433issue9
P304page(s)2337-2352
P577publication date2006-09-01
P1433published inDevelopmental DynamicsQ59752
P1476titleAnteroposterior patterning in the limb and digit specification: contribution of mouse genetics
P478volume235

Reverse relations

cites work (P2860)
Q41903862A unique protection signal in Cubitus interruptus prevents its complete proteasomal degradation
Q34370374Analysis of hedgehog signaling in mouse intraflagellar transport mutants
Q39300951Anterior-posterior differences in HoxD chromatin topology in limb development
Q34575070BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development
Q24644467Canine polydactyl mutations with heterogeneous origin in the conserved intronic sequence of LMBR1
Q46600830Cis-regulatory underpinnings of human GLI3 expression in embryonic craniofacial structures and internal organs.
Q58642322Finger, Sex, and Side Differences in Fingertip Size and Lack of Association with Image-Based Digit Ratio (2D:4D) Measurements
Q37779763Genetic and pathologic aspects of retinoic acid-induced limb malformations in the mouse
Q28751283Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
Q33281754Human GLI3 intragenic conserved non-coding sequences are tissue-specific enhancers
Q33567281Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development
Q28592776Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme
Q36173741Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development.
Q28472496Identification of a novel retinoid by small molecule screening with zebrafish embryos
Q39525476Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol.
Q34041473Molecular genetics of Müllerian duct formation, regression and differentiation
Q47073672Morphology of pelvic fin loss in a zebrafish strain (Danio rerio).
Q28507114Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway
Q37036052Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis
Q37369781Negative regulation of Hedgehog signaling by liver X receptors
Q34808308Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish
Q37329964Replication of long-bone length QTL in the F9-F10 LG,SM advanced intercross.
Q48230461Upstream regulation for initiation of restricted Shh expression in the chick limb bud.

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