Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme

scientific journal article

Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01168-07
P8608Fatcat IDrelease_axl6jqdh2fd3rfc6ihey3uhyd4
P932PMC publication ID2223317
P698PubMed publication ID17984226

P2093author name stringJian Zhang
Jian Huang
Trevor Williams
Weiguo Feng
P2860cites workHighly conserved non-coding sequences are associated with vertebrate developmentQ21092819
The AP-2 family of transcription factorsQ21184171
A new generation of JASPAR, the open-access repository for transcription factor binding site profilesQ25255984
Repeated morphological evolution through cis-regulatory changes in a pleiotropic geneQ28235451
The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineagesQ28504916
Transcription factor AP-2 essential for cranial closure and craniofacial developmentQ28513302
Requirement for AP-2alpha in cardiac outflow tract morphogenesisQ28584763
AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric miceQ28586197
AP-2alpha transcription factor is required for early morphogenesis of the lens vesicleQ28587027
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2Q28594321
MatInspector and beyond: promoter analysis based on transcription factor binding sitesQ29616314
Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesisQ33515610
Further evidence for the involvement of human chromosome 6p24 in the aetiology of orofacial cleftingQ33681429
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Making digit patterns in the vertebrate limbQ34496736
Comparative and functional analysis of the AP2 promoter indicates that conserved octamer and initiator elements are critical for activityQ34602256
Applied bioinformatics for the identification of regulatory elementsQ35766840
Comparative genomics at the vertebrate extremesQ35778678
Retinoid-induced limb malformationsQ35867179
The developing limb and the control of the number of digitsQ36023736
Anteroposterior patterning in the limb and digit specification: contribution of mouse geneticsQ36559423
Frontal nasal prominence expression driven by Tcfap2a relies on a conserved binding site for STAT proteinsQ37334244
A long-range regulatory element of Hoxc8 identified by using the pClasper vectorQ37694251
Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defectsQ38344566
Frontonasal process-specific disruption of AP-2alpha results in postnatal midfacial hypoplasia, vascular anomalies, and nasal cavity defectsQ38344570
lockjaw encodes a zebrafish tfap2a required for early neural crest development.Q38349455
SELEX and missing phosphate contact analyses reveal flexibility within the AP-2[alpha] protein: DNA binding complexQ39728282
Shuffling of cis-regulatory elements is a pervasive feature of the vertebrate lineageQ41852340
An interstitial deletion of 6p24-p25 proximal to the FKHL7 locus and including AP-2alpha that affects anterior eye chamber developmentQ41902872
Amphioxus and lamprey AP-2 genes: implications for neural crest evolution and migration patterns.Q42527237
Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotypeQ44610891
An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad miceQ44924708
The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development.Q47071789
Drosophila transcription factor AP-2 in proboscis, leg and brain central complex developmentQ47072053
Enhancer sequence conservation between vertebrates is favoured in developmental regulator genesQ48144721
Delineation of two distinct 6p deletion syndromesQ48267342
Identification and regulation of tissue‐specific cis‐acting elements associated with the human AP‐2α geneQ52099713
Overexpression of transcription factor AP-2alpha suppresses mammary gland growth and morphogenesis.Q52107622
Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds.Q52192985
Comparative analysis of AP-2 alpha and AP-2 beta gene expression during murine embryogenesis.Q52197891
The 6p deletion syndrome: a new orofacial clefting syndrome and its implications for antenatal screening.Q53458116
AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesisQ62818027
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectTranscription factor AP-2, alphaQ21982739
P304page(s)315–325
P577publication date2008-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleIdentification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme
P478volume28

Reverse relations

cites work (P2860)
Q90291182A functional indel polymorphism rs34396413 in TFAP2A intron-5 significantly increases female encephalocele risk in Han Chinese population
Q33857851Conservation in first introns is positively associated with the number of exons within genes and the presence of regulatory epigenetic signals
Q37178305Control elements in the neighboring ATPase gene influence spatiotemporal expression of the human agouti-related protein
Q81752916Expression levels of FAS are regulated through an evolutionary conserved element in intron 2, which modulates cystic fibrosis disease severity
Q28654627Functional analysis of limb transcriptional enhancers in the mouse
Q57444461Genetic Dissection of a Supergene Implicates in Craniofacial Evolution of Threespine Sticklebacks
Q35853942Hip geometry variation is associated with bone mineralization pathway gene variants: The Framingham Study.
Q33889301Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription
Q41696586Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development
Q47271603Modulation of FOXD3 activity in human embryonic stem cells directs pluripotency and paraxial mesoderm fates
Q36586217Molecular mechanisms of midfacial developmental defects
Q34876963Reduced TFAP2A function causes variable optic fissure closure and retinal defects and sensitizes eye development to mutations in other morphogenetic regulators
Q37668700Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development
Q24655671TFAP2A mutations result in branchio-oculo-facial syndrome
Q31039716The old and new face of craniofacial research: How animal models inform human craniofacial genetic and clinical data
Q35217337cis-regulatory mutations are a genetic cause of human limb malformations

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