Incretins and the development of type 2 diabetes

scientific article published on June 2006

Incretins and the development of type 2 diabetes is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1007/S11892-006-0034-7
P698PubMed publication ID16898571

P2093author name stringJuris J Meier
Michael A Nauck
P2860cites workHomeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manQ26776977
Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humansQ27865308
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose toleranceQ28186874
Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetesQ28212600
A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cellsQ28567736
Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humansQ33845996
Preparation of highly active enterogastroneQ34054149
Pancreatic and intestinal processing of proglucagon in man.Q34179390
Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginineQ34180164
Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitusQ34617065
Exon duplication and divergence in the human preproglucagon geneQ34713786
Gastric inhibitory polypeptide: the neglected incretin revisitedQ34758871
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitusQ35824086
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humansQ37377728
The incretin concept todayQ39227026
On the treatment of Diabetus mellitus by acid extract of Duodenal Mucous MembraneQ39468517
Immunoreactive gastric inhibitory polypeptideQ39642179
New developments in the incretin conceptQ39832287
Gastric inhibitory polypeptide.Q40083139
Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*Q40329405
Glucagon-like peptide 1 increases secretory burst mass of pulsatile insulin secretion in patients with type 2 diabetes and impaired glucose toleranceQ40715144
Hypersecretion of Gastric Inhibitory Polypeptide Following Oral Glucose in Diabetes MellitusQ40772590
Electronimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) im manQ40899849
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.Q41527377
Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.Q41710424
Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM.Q42435174
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjectsQ42436041
Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.Q42503767
Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrationsQ42511153
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).Q42574446
To be or not to be--an incretin or enterogastrone?Q42675447
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patientsQ43705651
Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetesQ43778779
GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretionQ43908148
Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patientsQ44110180
Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetesQ44467078
Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjectsQ44495085
The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotypeQ44616522
Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjectsQ44688781
Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitusQ44765354
Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired glucose toleranceQ44887107
Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose toleranceQ44953998
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetesQ45112803
Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.Q45161258
Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitusQ46466735
Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjectsQ46570584
Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes.Q46595558
The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humansQ46887678
Overnight GLP-1 normalizes fasting but not daytime plasma glucose levels in NIDDM patientsQ47970570
Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2.Q48218648
Glucagon-like peptide 1 (GLP-1): a potent gut hormone with a possible therapeutic perspectiveQ48335925
Hamster preproglucagon contains the sequence of glucagon and two related peptidesQ48398917
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans.Q51244259
Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.Q51550359
Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations.Q51560034
Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure.Q51567049
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.Q51584065
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.Q51599426
The glucose dependent insulinotropic polypeptide response to oral glucose and mixed meals is increased in patients with type 2 (non-insulin-dependent) diabetes mellitus.Q51619627
A Gastric Inhibitory Polypeptide II: The Complete Amino Acid SequenceQ53788072
The pathogenesis of NIDDM involves a defective expression of the GIP receptorQ58449027
Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*Q58449399
Identification of the intestinal cell storing gastric inhibitory peptideQ66897947
Reduced incretin effect in type 2 (non-insulin-dependent) diabetesQ68865252
Disturbances of the entero-insular axisQ70296199
Glucose-dependent Insulinotropic Polypeptide Augmentation of Insulin Physiology or Pharmacology?Q70332014
Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39Q77804907
Glucagon-like peptide 1 regulates sequential and compound exocytosis in pancreatic islet beta-cellsQ81118511
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responsesQ93538767
What are 'physiological' plasma GIP levels in man after intravenous infusion of porcine GIP?Q93561788
P433issue3
P921main subjecttype 2 diabetesQ3025883
P304page(s)194-201
P577publication date2006-06-01
P1433published inCurrent diabetes reportQ26841965
P1476titleIncretins and the development of type 2 diabetes
P478volume6

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