| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1111/J.0105-2896.2006.00419.X |
| P698 | PubMed publication ID | 16903911 |
| P50 | author | David M Sansom | Q42325358 |
| Lucy Walker | Q42812602 | ||
| P921 | main subject | cytotoxicity | Q246181 |
| P304 | page(s) | 131-148 | |
| P577 | publication date | 2006-08-01 | |
| P1433 | published in | Immunological Reviews | Q15724582 |
| P1476 | title | The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology | |
| P478 | volume | 212 |
| Q37818921 | A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis |
| Q36117526 | A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis |
| Q37454367 | ANCA-associated vasculitis: from bench research to novel treatments |
| Q36802625 | ANCA-associated vasculitis: new options beyond steroids and cytotoxic drugs |
| Q34154623 | Accumulation of CCR4⁺CTLA-4 FOXP3⁺CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells |
| Q24315715 | Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3 |
| Q56901055 | Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice |
| Q53559269 | An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. |
| Q54511300 | Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of Standard Immune Cell Types. |
| Q44691678 | Analysis of CTLA4 gene variant in infertile Brazilian women with and without endometriosis. |
| Q53594266 | Autoantibodies against CD28 are associated with atopic diseases. |
| Q28250000 | Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations |
| Q37965932 | Belatacept: from rational design to clinical application |
| Q56896828 | CD 152 gene polymorphisms and risk of osteosarcoma in Chinese population |
| Q37864546 | CD28 co-signaling in the adaptive immune response. |
| Q45743806 | CD28 costimulation: walking the immunological tightrope |
| Q41810884 | CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis. |
| Q41467332 | CD300 heterocomplexes, a new and family-restricted mechanism for myeloid cell signaling regulation. |
| Q37333485 | CD4+ CD25+ Foxp3- T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted fever rickettsiosis |
| Q36229540 | CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. |
| Q37157989 | CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance |
| Q48239167 | CTLA-4 polymorphisms: influence on transplant-related mortality and survival in children undergoing allogeneic hematopoietic stem cell transplantation. |
| Q54546709 | CTLA-4 x Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells. |
| Q56899384 | CTLA4 -1661A/G and 3'UTR long repeat polymorphisms are associated with ulcerative colitis and influence CTLA4 mRNA and protein expression |
| Q37254718 | CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population |
| Q37196273 | CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis |
| Q34083388 | CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer |
| Q42626979 | CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β. |
| Q37098427 | Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease |
| Q26824580 | Cellular targeting in autoimmunity |
| Q34671498 | Clinical Development of Immune Checkpoint Inhibitors |
| Q37206791 | Clinical relevance of the severe abnormalities of the T cell compartment in septic shock patients |
| Q38897638 | Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go? |
| Q92060148 | Combination Strategies of Checkpoint Immunotherapy in Metastatic Breast Cancer |
| Q34110557 | Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells |
| Q34658652 | Comparison of the intracellular trafficking itinerary of ctla-4 orthologues |
| Q35842036 | Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation |
| Q37335249 | Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. |
| Q37398076 | Current concepts in the pathogenesis of early rheumatoid arthritis |
| Q37135023 | Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases. |
| Q54264728 | Cytotoxic T-lymphocyte antigen 4 (CTLA4) +49AG and CT60 gene polymorphisms in Alopecia Areata: a case-control association study in the Italian population. |
| Q64945673 | Decreased regulatory T-cell frequency and interleukin-35 levels in patients with rheumatoid arthritis. |
| Q37039571 | Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis |
| Q56901192 | Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function |
| Q56900502 | Detection of T-regulatory cells has a potential role in the diagnosis of classical Hodgkin lymphoma |
| Q34774093 | Differences in the induction of induced human CD4(+) CD25(+) FoxP3(+) T-regulatory cells and CD3(+) CD8(+) CD28(-) T-suppressor cells subset phenotypes in vitro: comparison of phorbol 12-myristate 13-acetate/ionomycin and phytohemagglutinin stimulat |
| Q34633776 | Dysregulated expression of both the costimulatory CD28 and inhibitory CTLA-4 molecules in PB T cells of advanced cervical cancer patients suggests systemic immunosuppression related to disease progression |
| Q37614743 | Elevated regulatory T cells, surface and intracellular CTLA-4 expression and interleukin-17 in the lung cancer microenvironment in humans. |
| Q33685307 | Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs |
| Q35931188 | Evaluation of Costimulatory Molecules in Peripheral Blood Lymphocytes of Canine Patients with Histiocytic Sarcoma |
| Q39594173 | Ex vivo expanded regulatory T cells CD4(+)CD25(+)FoxP3(+)CD127(Low) develop strong immunosuppressive activity in patients with remitting-relapsing multiple sclerosis |
| Q37294572 | Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy |
| Q37698501 | Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma. |
| Q56899642 | FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua |
| Q34111789 | Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma |
| Q35829151 | Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras |
| Q37679222 | Galiximab: a review |
| Q50517775 | Generation and function of immunosuppressive human and murine CD8+ T cells by transforming growth factor-β and retinoic acid. |
| Q64074640 | Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes |
| Q42432007 | HIV-specific TGF-beta-positive CD4+ T cells do not express regulatory surface markers and are regulated by CTLA-4. |
| Q36202863 | Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor- 1. |
| Q26853599 | Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs |
| Q33800947 | Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile. |
| Q51013880 | Human plasmacytoid dendritic cells induce CD8⁺ LAG-3⁺ Foxp3⁺ CTLA-4⁺ regulatory T cells that suppress allo-reactive memory T cells. |
| Q42246343 | Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08. |
| Q56901469 | ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells |
| Q47235478 | Identification of key genes implicated in the suppressive function of human FOXP3+CD25+CD4+ regulatory T cells through the analysis of time‑series data |
| Q56898473 | Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model |
| Q42590646 | Immunomodulatory effects of mesenchymal stromal cells in Crohn's disease |
| Q64916418 | Immunophenotype of T Cells Expressing Programmed Death-1 and Cytotoxic T Cell Antigen-4 in Early Lung Cancer: Local vs. Systemic Immune Response. |
| Q36409570 | Impaired regulatory function in circulating CD4(+)CD25(high)CD127(low/-) T cells in patients with myasthenia gravis |
| Q37069874 | Increased T regulatory cells lead to development of Th2 immune response in male SJL mice |
| Q45873690 | Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controls |
| Q42457039 | Increased numbers of thymic and peripheral CD4+ CD25+Foxp3+ cells in the absence of CD5 signaling |
| Q39017623 | Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora? |
| Q56895331 | Interleukin 10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis |
| Q45823097 | Interleukin-7 matures suppressive CD127(+) forkhead box P3 (FoxP3)(+) T cells into CD127(-) CD25(high) FoxP3(+) regulatory T cells. |
| Q37864700 | Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family |
| Q36973929 | Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. |
| Q50928165 | Lack of association between cytotoxic T-lymphocyte antigen-4 -318C/T polymorphism and cancer risk: a meta-analysis of case-control studies. |
| Q37408819 | Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis |
| Q36942521 | Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies |
| Q42145973 | Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities |
| Q26744635 | Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules |
| Q37737987 | Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease |
| Q36067577 | Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's |
| Q28744304 | Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human |
| Q33622404 | Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms |
| Q38923489 | Novel melanoma therapy |
| Q42586051 | PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells |
| Q28609463 | PIP3 pathway in regulatory T cells and autoimmunity |
| Q36896203 | Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours |
| Q36920484 | Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells |
| Q40364765 | Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia |
| Q37135949 | Prostaglandin E2 affects T cell responses through modulation of CD46 expression |
| Q44425008 | Quantification and molecular characterization of regulatory T cells in connective tissue diseases |
| Q36448950 | Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis |
| Q34631162 | Recombinant Wolbachia surface protein (WSP)-induced T cell responses in Wuchereria bancrofti infections |
| Q33995866 | Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells |
| Q37474900 | Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells |
| Q41732634 | Regulatory T Cell Numbers in Inflamed Skin Are Controlled by Local Inflammatory Cues That Upregulate CD25 and Facilitate Antigen-Driven Local Proliferation |
| Q26995751 | Regulatory T cell in stroke: a new paradigm for immune regulation |
| Q42554303 | Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors. |
| Q34166571 | Regulatory T cells and their roles in immune dysregulation and allergy. |
| Q38224322 | Regulatory tone and mucosal immunity in asthma |
| Q26798141 | Research Progress on Regulatory T Cells in Acute Kidney Injury |
| Q27666303 | Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering |
| Q34177314 | Role of circulating lymphocytes in patients with sepsis |
| Q38008336 | Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells |
| Q34826137 | Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy |
| Q44628780 | Subpopulations of equine blood lymphocytes expressing regulatory T cell markers. |
| Q38918455 | Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation. |
| Q41207399 | Superior Suppressive Capacity of Skin Tregs Compared to Lung Tregs in a Model of Epicutaneous Priming |
| Q41006327 | Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming |
| Q33987835 | T regulatory cells and transplantation tolerance |
| Q33952389 | T regulatory cells are markers of disease activity in multiple sclerosis patients |
| Q33519047 | TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells |
| Q36989149 | TGFbeta1 and Treg cells: alliance for tolerance |
| Q39127438 | TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells |
| Q27340853 | Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells |
| Q34164169 | Targeting regulatory T cells to improve vaccine immunogenicity in early life |
| Q37176537 | Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens |
| Q24673258 | The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future |
| Q44393406 | The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses |
| Q38350483 | The impact of biological therapy on regulatory T cells in rheumatoid arthritis |
| Q37363060 | The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. |
| Q36747499 | The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease |
| Q39015080 | Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders. |
| Q38098467 | Therapeutic potential of regulatory T cells in autoimmune disorders. |
| Q26860731 | Trauma equals danger--damage control by the immune system |
| Q37321716 | Treatment of graft-versus-host disease with naturally occurring T regulatory cells |
| Q37154141 | Treatment with selective estrogen receptor modulators regulates myelin specific T-cells and suppresses experimental autoimmune encephalomyelitis |
| Q38121260 | Treg and CTLA-4: two intertwining pathways to immune tolerance |
| Q37085357 | Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells |
| Q37909430 | Using monoclonal antibodies to stimulate antitumor cellular immunity |
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