p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines

scientific article published on 23 December 2015

p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00280-015-2944-Z
P932PMC publication ID4749432
P698PubMed publication ID26698867
P5875ResearchGate publication ID288001874

P2093author name stringCao Yang
Edwin Choy
Zhenfeng Duan
Henry Mankin
Francis Hornicek
Jacson Shen
Shunan Ye
P2860cites workInduction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotideQ22008744
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
IGF binding proteins in cancer: mechanistic and clinical insightsQ28237971
Lost in transcription: p21 repression, mechanisms, and consequencesQ28251319
Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplicationQ28611456
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
Targeting multidrug resistance in cancerQ29616803
Cellular processing of platinum anticancer drugsQ29617899
Insulin and insulin-like growth factor signalling in neoplasiaQ29619495
Molecular determinants of treatment response in human germ cell tumorsQ33185999
The coordinate regulation of the p53 and mTOR pathways in cellsQ33840457
Novel mechanisms of drug resistance in leukemiaQ33864560
Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachQ33925323
Rescue of MHC-1 antigen processing machinery by down-regulation in expression of IGF-1 in human glioblastoma cellsQ34634158
Insulin-like growth factor-dependent proliferation and survival of triple-negative breast cancer cells: implications for therapyQ35042972
Paclitaxel resistance: molecular mechanisms and pharmacologic manipulationQ35060814
Differential effects of cell cycle regulatory protein p21(WAF1/Cip1) on apoptosis and sensitivity to cancer chemotherapyQ35214619
p53 and P-glycoprotein are often co-expressed and are associated with poor prognosis in breast cancerQ36135594
Treatment of osteosarcoma at first recurrence after contemporary therapy: the Memorial Sloan-Kettering Cancer Center experience.Q36277346
The modulation of inter-organelle cross-talk to control apoptosisQ36513159
Chemotherapy resistance in osteosarcoma: current challenges and future directions.Q36532115
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.Q36536479
DNA damage-induced cell death by apoptosis.Q36561337
WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinasesQ36570903
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.Q37397276
Overcoming drug resistance by enhancing apoptosis of tumor cells.Q37481518
Nanoparticles: a promising modality in the treatment of sarcomas.Q37761069
p53: the attractive tumor suppressor in the cancer research fieldQ37824262
Molecular mechanisms of cisplatin resistanceQ37926477
Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapyQ37975246
Interleukin-6 signaling pathway in targeted therapy for cancerQ38014987
Ionizing radiation-induced responses in human cells with differing TP53 statusQ38162722
p53 as a target for the treatment of cancer.Q38279586
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathwaysQ39077231
Synthesis and evaluation of (2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) isomers to reverse multidrug resistance in cancerQ39383358
Direct induction of apoptosis using an optimal mitochondrially targeted p53.Q39387682
Loss-of-function genetic screening identifies a cluster of ribosomal proteins regulating p53 functionQ39976649
Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J.Q40209979
Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicinQ40364572
Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cellsQ40399026
Characterization of salvicine-resistant lung adenocarcinoma A549/SAL cell lineQ40555425
Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.Q40788757
Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivoQ40935658
Cell cycle-dependent regulation of nuclear p53 traffic occurs in one subclass of human tumor cells and in untransformed cellsQ41170917
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.Q42797525
p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax.Q44511919
Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapyQ44667120
Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expressionQ46709821
A universal gene carrier platform for treatment of human prostatic carcinoma by p53 transfectionQ50464048
Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.Q51929126
Mechanisms of resistance to apoptosis in human AML blasts: the role of differentiation-induced perturbations of cell-cycle checkpoints.Q52538783
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.Q52561781
Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistanceQ58282980
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell LinesQ72561176
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndromeQ81166001
P433issue2
P921main subjectmultiple drug resistanceQ643839
overexpressionQ61643320
P304page(s)349-356
P577publication date2015-12-23
P1433published inCancer Chemotherapy and PharmacologyQ326137
P1476titlep53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines
P478volume77