Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.

scientific article published on 27 December 2012

Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMCL.2012.12.037
P932PMC publication ID3557747
P698PubMed publication ID23324406

P50authorBoris StriepenQ48086103
Corey R JohnsonQ85905588
P2093author name stringXiaoping Liu
Jan R Mead
Gregory D Cuny
Lizbeth Hedstrom
Mandapati Kavitha
Minjia Zhang
Suresh Kumar Gorla
P2860cites workComplete Genome Sequence of the Apicomplexan, Cryptosporidium parvumQ22065819
The genome of Cryptosporidium hominisQ22122489
IMP dehydrogenase: structure, mechanism, and inhibitionQ24642299
The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor SelectivityQ27658866
A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenaseQ28475058
Genetic complementation in apicomplexan parasitesQ30701283
Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenaseQ33604996
Prodrug activation by Cryptosporidium thymidine kinaseQ33855150
An updated review on Cryptosporidium and GiardiaQ34552857
Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.Q35787804
Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosisQ36740182
Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenaseQ36791988
Gene transfer in the evolution of parasite nucleotide biosynthesisQ36854287
Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug designQ39541748
Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congenersQ41162065
Mucosal cytokine and antigen-specific responses to Cryptosporidium parvum in IL-12p40 KO mice.Q53861788
Susceptibility to Cryptosporidium parvum infections in cytokine- and chemokine-receptor knockout miceQ78523924
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectCryptosporidium parvumQ134734
P304page(s)1004-1007
P577publication date2012-12-27
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titlePhthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum
P478volume23

Reverse relations

cites work (P2860)
Q35126722A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity
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Q40121791Benzoxazoles, phthalazinones, and arylurea-based compounds with IMPDH-independent antibacterial activity against Francisella tularensis.
Q41227778Binding mode of inhibitors and Cryptosporidium parvum IMP dehydrogenase: A combined ligand- and receptor-based study
Q92290892Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum
Q30248799Cryptosporidium in humans and animals-a one health approach to prophylaxis.
Q53684814Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.
Q41105047Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics
Q38558374Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.
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Q28550069Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds
Q27678115Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase
Q30371392Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.
Q37428599Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.
Q35592527Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity
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Q90914855Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease
Q37643702Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis

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