Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress.

scientific article published on 27 March 2008

Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2008.070310
P8608Fatcat IDrelease_v724jywdlbdwpi3emtnrd5n2ue
P932PMC publication ID2329829
P698PubMed publication ID18372427
P5875ResearchGate publication ID5481065

P50authorOlivier TabaryQ57196003
Vinciane Saint-CriqQ80971717
P2093author name stringAlexandra Henrion-Caude
Annick Clement
Monique Bonora
Elise Bonvin
Emilie Boncoeur
Jacky Jacquot
Telma Roque
P2860cites workDigitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cellsQ24562089
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Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.Q42830960
Evidence that inhibition of p44/42 mitogen-activated protein kinase signaling is a factor in proteasome inhibitor-mediated apoptosisQ44002712
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Longitudinal study of oxidative status in 312 cystic fibrosis patients in stable state and during bronchial exacerbationQ44916257
Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosisQ45091453
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Oxidative stress response results in increased p21WAF1/CIP1 degradation in cystic fibrosis lung epithelial cells.Q46842795
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Disturbed myeloperoxidase-dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amilorideQ71527856
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NF-kappaB protects lung epithelium against hyperoxia-induced nonapoptotic cell death-oncosisQ80846538
Arrest of CFTRDeltaF508 foldingQ81358747
Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout miceQ81370790
Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activationQ28292768
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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
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Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexinQ33836913
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Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.Q34162541
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Molecular sequelae of proteasome inhibition in human multiple myeloma cellsQ34393832
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NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approachQ35036569
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Oxidative stress during acute respiratory exacerbations in cystic fibrosis.Q35533117
Genistein inhibits constitutive and inducible NFkappaB activation and decreases IL-8 production by human cystic fibrosis bronchial gland cellsQ35787767
Glutathione, stress responses, and redox signaling in lung inflammation.Q36009340
A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligaseQ36322876
Antioxidants in cystic fibrosis. Conclusions from the CF antioxidant workshop, Bethesda, Maryland, November 11-12, 2003.Q36677933
Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant miceQ37098621
Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cellsQ37383069
Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxiaQ37486505
Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB.Q38322916
Oxidative stress induces extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: Potential mechanism for excessive IL-8 expression.Q40067729
Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.Q40115646
Identification of new small molecule inhibitors of cystic fibrosis transmembrane conductance regulator protein: in vitro and in vivo studiesQ40165210
Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expressionQ40229391
Oxidant stress suppresses CFTR expressionQ40373518
Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cellsQ40387796
High abundance protein profiling of cystic fibrosis lung epithelial cellsQ40428063
Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell LineQ40521090
Caspase activation inhibits proteasome function during apoptosisQ40569376
Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas.Q40726462
Transcription factors and asthmaQ40846857
p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cellsQ40910459
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cellsQ40956388
CFTR as a cAMP-dependent regulator of sodium channelsQ41312779
The role of nuclear factor-kappa B in cytokine gene regulationQ41532089
A Cystic Fibrosis Bronchial Epithelial Cell Line: Immortalization by Adeno-12-SV40 InfectionQ41689566
Signal transduction through NF-kappa B.Q41724478
Pulmonary oxidative stress response in young children with cystic fibrosisQ42152011
Mechanism of direct degradation of IkappaBalpha by 20S proteasomeQ42482608
Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cellsQ42492799
CFTR inhibition mimics the cystic fibrosis inflammatory profileQ42500060
Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalphaQ42511840
Suppression of nuclear factor-kappa B activity by nitric oxide and hyperoxia in oxygen-resistant cellsQ42810670
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitiveQ42816994
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
cystic fibrosisQ178194
P304page(s)1184-1194
P577publication date2008-03-27
P1433published inThe American Journal of PathologyQ4744259
P1476titleCystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress
P478volume172

Reverse relations

cites work (P2860)
Q39314424CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer
Q36623329Cystic fibrosis: a mucosal immunodeficiency syndrome.
Q37264720Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells
Q57282398Oxidative stress, autophagy and airway ion transport
Q38337325Sustained inhibition of IL-6 and IL-8 expression by decoy ODN to NF-κB delivered through respirable large porous particles in LPS-stimulated cystic fibrosis bronchial cells

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