Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector

scientific article published on 12 August 2015

Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MT.2015.146
P932PMC publication ID4754539
P698PubMed publication ID26265250

P50authorOlivier BoyerQ39066473
Romain HardetQ49740489
Sahil AdriouchQ56701796
Anna SalvettiQ61804512
P2093author name stringLaurent Drouot
Benjamin Chevalier
Gaëtan Riou
Laetitia Jean
Léa Dupaty
Yassine Naïmi
P2860cites workSafety and efficacy of gene transfer for Leber's congenital amaurosisQ24634724
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Progress and prospects: immune responses to viral vectorsQ28264531
Ecto-enzyme and signaling functions of lymphocyte CD73Q28268472
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cellsQ28289781
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune responseQ29619095
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cellsQ33624770
Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B miceQ33859520
Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cellsQ34137024
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.Q34168942
Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+ T cellsQ34263314
Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trialQ34311144
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathwayQ34340613
Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injectionQ34770058
Long-term safety and efficacy of factor IX gene therapy in hemophilia B.Q34783922
Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cellsQ35348677
Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer.Q35451204
Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.Q35591418
Adenovirus-associated virus vector-mediated gene transfer in hemophilia BQ35691659
Systemic protein delivery by muscle-gene transfer is limited by a local immune responseQ35847626
Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in miceQ35913697
AAV-mediated gene transfer for treatment of hemophiliaQ36173013
Plasmacytoid dendritic cells mediate oral toleranceQ36534744
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trialQ36632019
Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cellsQ36640081
Immune responses to AAV vectors: overcoming barriers to successful gene therapyQ36983740
The molecular signature of CD8+ T cells undergoing deletional toleranceQ37187520
Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactisQ37642861
The complex and evolving story of T cell activation to AAV vector-encoded transgene productsQ37814051
Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challengesQ37866086
Immune responses to AAV in clinical trialsQ37873955
Immunity and AAV-Mediated Gene Therapy for Muscular Dystrophies in Large Animal Models and Human TrialsQ37943306
Advances in recombinant adeno-associated viral vectors for gene deliveryQ38141288
Immune Responses to AAV-Vectors, the Glybera Example from Bench to BedsideQ38195598
Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapyQ38287263
Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses.Q39303013
Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and DQ39881602
Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B.Q40485786
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions.Q42138485
Priming of memory but not effector CD8 T cells by a killed bacterial vaccineQ43921694
CD8(+) T-cell responses to adeno-associated virus capsid in humansQ45406111
Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: a randomized controlled trialQ45847519
Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene productsQ45868913
Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX.Q45869966
Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transferQ45874902
Major role of local immune responses in antibody formation to factor IX in AAV gene transferQ45883516
Transient immunosuppression allows transgene expression following readministration of adeno-associated viral vectorsQ45886179
Oral tolerance correlates with high levels of lymphocyte activity.Q46638037
Kinetic analysis of oral tolerance: memory lymphocytes are refractory to oral tolerance.Q52032008
Antigen-specific T cell activation and proliferation during oral tolerance induction.Q52034130
Peripheral deletion of antigen-reactive T cells in oral tolerance.Q54167741
Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administrationQ56904883
Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory propertiesQ73196801
Oral toleranceQ83849376
Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD miceQ87544988
Interleukin-10-secreting Peyer's patch cells are responsible for active suppression in low-dose oral toleranceQ95721788
P433issue1
P921main subjectviral persistenceQ44134905
P304page(s)87-95
P577publication date2015-08-12
P1433published inMolecular TherapyQ15762400
P1476titleOral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector
P478volume24

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cites work (P2860)
Q39394803Complexity of immune responses to AAV transgene products - Example of factor IX.
Q52721830Gene Therapy With Regulatory T Cells: A Beneficial Alliance.
Q37609101Ghrelin-Reactive Immunoglobulins in Conditions of Altered Appetite and Energy Balance
Q37256518Induction of Hematopoietic Microchimerism by Gene-Modified BMT Elicits Antigen-Specific B and T Cell Unresponsiveness toward Gene Therapy Products
Q49740101Oral Tolerance: Another Reason to Eat Your Veggies!
Q40049410Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer
Q38684383Site-Specific PEGylated Adeno-Associated Viruses with Increased Serum Stability and Reduced Immunogenicity
Q54402965The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research.
Q64059399Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity

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