| scholarly article | Q13442814 |
| P50 | author | Robert Z Orlowski | Q91428664 |
| P2093 | author name string | Keiko Nakayama | |
| Keiichi I Nakayama | |||
| Frank Mercurio | |||
| Qing Chen | |||
| Peter M Voorhees | |||
| Deborah J Kuhn | |||
| Weilin Xie | |||
| Antonia Lopez-Girona | |||
| Derek Mendy | |||
| David R Webb | |||
| Weiming Xu | |||
| Laura G Corral | |||
| Laure Moutouh-de Parseval | |||
| Veronique Plantevin Krenitsky | |||
| P2860 | cites work | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex | Q24294734 |
| Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells | Q24299982 | ||
| WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy | Q24322858 | ||
| Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase | Q24337721 | ||
| Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy | Q27931770 | ||
| SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 | Q28137860 | ||
| The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 | Q28202908 | ||
| Regulation of the cell cycle by SCF-type ubiquitin ligases | Q28245984 | ||
| Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma | Q28274310 | ||
| Ubiquitin ligases: cell-cycle control and cancer | Q29617992 | ||
| The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis | Q29622875 | ||
| Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer | Q33281087 | ||
| A phase 2 study of bortezomib in relapsed, refractory myeloma | Q33348702 | ||
| Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression | Q33376149 | ||
| Regulation of the cdk inhibitor p27 and its deregulation in cancer | Q33853211 | ||
| Protein destruction: adapting roles for Cks proteins | Q34343142 | ||
| Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. | Q34375642 | ||
| Molecular sequelae of proteasome inhibition in human multiple myeloma cells | Q34393832 | ||
| Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer | Q34415244 | ||
| Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer | Q34436736 | ||
| Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate | Q34984389 | ||
| Targeting E3 ubiquitin ligases for cancer therapy. | Q35612694 | ||
| CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms | Q35828815 | ||
| Methods for monitoring autophagy | Q35869399 | ||
| Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas | Q35989467 | ||
| The role of autophagy in cancer development and response to therapy. | Q36251939 | ||
| Low p27 expression predicts poor disease-free survival in patients with prostate cancer | Q38472792 | ||
| p27kip1 overexpression promotes paclitaxel-induced apoptosis in pRb-defective SaOs-2 cells | Q40295116 | ||
| Elongation factor-2 kinase regulates autophagy in human glioblastoma cells | Q40304166 | ||
| Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo | Q40310965 | ||
| The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells | Q40440435 | ||
| Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits cell growth of oral cancer cells by inhibiting p27 degradation | Q40446705 | ||
| Elevated S-phase kinase-associated protein 2 protein expression in acute myelogenous leukemia: its association with constitutive phosphorylation of phosphatase and tensin homologue protein and poor prognosis | Q40528005 | ||
| The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase | Q40552228 | ||
| Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells | Q40600919 | ||
| Low p27Kip1 expression is an independent adverse prognostic factor in patients with multiple myeloma. | Q40606160 | ||
| p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells | Q40918524 | ||
| The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications | Q44211035 | ||
| MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. | Q44412861 | ||
| Identification of caspase-independent apoptosis in epithelial and cancer cells | Q44804081 | ||
| A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. | Q46229708 | ||
| Bortezomib or high-dose dexamethasone for relapsed multiple myeloma | Q46549268 | ||
| Expression of cyclin E and p27(KIP1) in cervical carcinoma. | Q53410652 | ||
| Low p27Kip1 expression is an independent prognostic factor in gallbladder carcinoma | Q73225602 | ||
| p27Kip1 expression is associated with clinical outcome in advanced epithelial ovarian cancer: multivariate analysis | Q73393218 | ||
| P27KiP1 overexpression inhibits the growth and doxorubicin sensitivity of HT29 human colon cancer cells in vivo | Q73790812 | ||
| Expression of p27Kip1 and cyclin D1 proteins is inversely correlated and is associated with poor clinical outcome in human gastric cancer | Q77995649 | ||
| Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation | Q80061608 | ||
| Regulation of SCF(SKP2) ubiquitin E3 ligase assembly and p27(KIP1) proteolysis by the PTEN pathway and cyclin D1 | Q80167540 | ||
| TNFalpha resistance in MCF-7 breast cancer cells is associated with altered subcellular localization of p21CIP1 and p27KIP1 | Q81126737 | ||
| RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells | Q81449583 | ||
| Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib | Q83930160 | ||
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | autophagy | Q288322 |
| P304 | page(s) | 4690-4699 | |
| P577 | publication date | 2008-02-27 | |
| P1433 | published in | Blood | Q885070 |
| P1476 | title | Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy | |
| P478 | volume | 111 |
| Q35848294 | A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis |
| Q34406424 | A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition. |
| Q93197932 | A patent review of the ubiquitin ligase system: 2015-2018 |
| Q37711659 | Acquisition of epithelial-mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells |
| Q38285170 | Antitumor mechanisms when pRb and p53 are genetically inactivated |
| Q38134372 | Autophagy in blood cancers: biological role and therapeutic implications. |
| Q28478548 | Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells |
| Q36808366 | Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. |
| Q34551213 | BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein |
| Q34785991 | Biological Activity of N-Hydroxyethyl-4-aza-2,3-didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells |
| Q92987584 | CRISPR/Cas9 Editing of the Polyomavirus Tumor Antigens Inhibits Merkel Cell Carcinoma Growth In Vitro |
| Q91733324 | Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth |
| Q36206479 | Cell cycle control in acute myeloid leukemia. |
| Q49091154 | Changes in Pirh2 and p27kip1 expression following traumatic brain injury in adult rats |
| Q42022306 | Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase |
| Q52730051 | Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8. |
| Q35209185 | Comprehensive analysis of loops at protein-protein interfaces for macrocycle design |
| Q34058325 | Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells |
| Q37630073 | Control of cell proliferation in atherosclerosis: insights from animal models and human studies. |
| Q38059746 | Cullin-RING Ligases as attractive anti-cancer targets |
| Q33650304 | Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells |
| Q37298290 | Curcumin inhibits cell growth and invasion and induces apoptosis through down-regulation of Skp2 in pancreatic cancer cells |
| Q36228504 | Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells |
| Q26825417 | DangER: protein ovERload. Targeting protein degradation to treat myeloma |
| Q36665479 | Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed |
| Q35044801 | Development of inhibitors in the ubiquitination cascade |
| Q94459360 | Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors |
| Q35227386 | Downregulation of ubiquitin inhibits the proliferation and radioresistance of non-small cell lung cancer cells in vitro and in vivo |
| Q54452713 | Dynamic changes of Jab1 and p27kip1 expression in injured rat sciatic nerve. |
| Q85017902 | Dynamic changes of PIRH2 and p27kip1 expression in injured rat sciatic nerve |
| Q33705444 | E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration |
| Q47636038 | E3 ubiquitin ligases in cancer and implications for therapies |
| Q64104228 | Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers |
| Q35009005 | Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma. |
| Q34441649 | Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 |
| Q54518212 | Expression of Spy1 protein in human non-Hodgkin's lymphomas is correlated with phosphorylation of p27 Kip1 on Thr187 and cell proliferation. |
| Q36099459 | Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components |
| Q90746433 | F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects |
| Q49444302 | Genistein inhibits the S-phase kinase-associated protein 2 expression in breast cancer cells |
| Q35174542 | Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells. |
| Q34139564 | Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. |
| Q34889802 | Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high-throughput screening. |
| Q37435516 | Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras. |
| Q53622363 | Immunohistochemically detected expression of Skp2, p27 kip1, and p-p27 (Thr187) in patients with cholangiocarcinoma. |
| Q36334266 | Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapy |
| Q90589705 | LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas |
| Q51784666 | Lipopolysaccharide-induced early response genes in bovine peripheral blood mononuclear cells implicate GLG1/E-selectin as a key ligand-receptor interaction. |
| Q34648675 | MYCN transgenic zebrafish model with the characterization of acute myeloid leukemia and altered hematopoiesis |
| Q37706977 | Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2. |
| Q53071967 | Mechanisms in cardiac fibroblast growth: an obligate role for Skp2 and FOXO3a in ERK1/2 MAPK-dependent regulation of p27kip1. |
| Q38035044 | Molecular mechanisms of effectiveness of novel therapies in multiple myeloma |
| Q92940880 | Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway |
| Q37971404 | Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis |
| Q26773246 | Novel strategies to target the ubiquitin proteasome system in multiple myeloma |
| Q38156100 | Oncoprotein stabilization in brain tumors. |
| Q31077436 | Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest |
| Q47177215 | PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines |
| Q36146344 | Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma |
| Q24314416 | Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression |
| Q35559055 | Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases |
| Q27938750 | Positive or negative roles of different cyclin-dependent kinase Pho85-cyclin complexes orchestrate induction of autophagy in Saccharomyces cerevisiae |
| Q38845220 | Post-translational modification profiling - A novel tool for mapping the protein modification landscape in cancer |
| Q89984846 | Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy |
| Q36110509 | Prodigiosin down-regulates SKP2 to induce p27(KIP1) stabilization and antiproliferation in human lung adenocarcinoma cells |
| Q37564753 | RRD-251 enhances all-trans retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells |
| Q38052131 | Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases |
| Q38828721 | Recent advances in SCF ubiquitin ligase complex: Clinical implications |
| Q37388126 | Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer |
| Q35012352 | Roles of F-box proteins in cancer |
| Q37687014 | Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells |
| Q38644806 | S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells |
| Q35880315 | SCF E3 ubiquitin ligases as anticancer targets |
| Q38267996 | SCF ubiquitin ligase-targeted therapies. |
| Q84316177 | SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection |
| Q39032869 | SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer |
| Q37745129 | Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells. |
| Q36544267 | Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors |
| Q36817623 | Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation |
| Q41686942 | Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist |
| Q37433516 | Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors |
| Q64087876 | Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis |
| Q35687208 | Skp2 is a promising therapeutic target in breast cancer |
| Q42366668 | Skp2: a dream target in the coming age of cancer therapy. |
| Q24625558 | Skp2: a novel potential therapeutic target for prostate cancer |
| Q54992503 | Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets. |
| Q36600976 | Small molecule therapeutics targeting F-box proteins in cancer |
| Q43723696 | Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients |
| Q24596988 | Specific small molecule inhibitors of Skp2-mediated p27 degradation |
| Q50853038 | Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants. |
| Q38646896 | Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases |
| Q47330544 | THANATOS: an integrative data resource of proteins and post-translational modifications in the regulation of autophagy. |
| Q24300101 | TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells |
| Q34043797 | Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation |
| Q38960661 | Targeting phospho-MARCKS overcomes drug-resistance and induces antitumor activity in preclinical models of multiple myeloma |
| Q36062128 | Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application |
| Q26866185 | Targeting the ubiquitin pathway for cancer treatment |
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| Q37158445 | Targeting ubiquitination for cancer therapies. |
| Q39799320 | Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling |
| Q26777305 | The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers |
| Q37902052 | The autophagic paradox in cancer therapy |
| Q36213657 | The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation |
| Q36956895 | The non-canonical functions of p27(Kip1) in normal and tumor biology |
| Q39116900 | The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells. |
| Q90093670 | The role of ubiquitination in tumorigenesis and targeted drug discovery |
| Q38087182 | The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer |
| Q35824929 | The ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discovery |
| Q64243914 | Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma |
| Q38344277 | Transcription factors and cognate signalling cascades in the regulation of autophagy |
| Q64078011 | USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia |
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| Q38021448 | Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications |
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| Q89574008 | miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential |
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