Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion.

scientific article published on 29 November 2012

Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPGI.00074.2012
P932PMC publication ID3566511
P698PubMed publication ID23203156
P5875ResearchGate publication ID233829440

P50authorAndrew W. MoranQ41422849
Miran Al-RammahiQ82081302
Soraya P Shirazi-BeecheyQ87976899
P2093author name stringYuzo Ninomiya
Kristian Daly
Marco Marcello
P2860cites workNew SeasoningsQ22337153
Human receptors for sweet and umami tasteQ22337199
An amino-acid taste receptorQ22337237
The receptors and cells for mammalian tasteQ22337248
T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1Q24682744
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1Q24682766
L-amino acid sensing by the extracellular Ca2+-sensing receptorQ28344208
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120Q28507400
Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cellsQ28587646
Umami taste responses are mediated by alpha-transducin and alpha-gustducinQ28594563
Mammalian sweet taste receptorsQ29614809
Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteinsQ30010478
Genetically-increased taste cell population with G(alpha)-gustducin-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in miceQ33520351
Responses to umami substances in taste bud cells innervated by the chorda tympani and glossopharyngeal nervesQ33874666
Basic properties of umami and effects on humansQ33997085
Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulationQ34010026
Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.Q34091575
CholecystokininQ34096294
Extracellular calcium sensing and extracellular calcium signalingQ34127766
The receptors for mammalian sweet and umami tasteQ34278862
Gustducin is a taste-cell-specific G protein closely related to the transducinsQ34440920
Sodium/glucose cotransporter-1, sweet receptor, and disaccharidase expression in the intestine of the domestic dog and cat: two species of different dietary habit.Q34502127
Intestinal glucose sensing and regulation of intestinal glucose absorption.Q34655277
Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humansQ34762282
Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptorQ34783968
The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cellsQ34783985
Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1.Q34979979
In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profileQ36020861
The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokininQ36477035
Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiologyQ36618910
Molecular mechanism for the umami taste synergismQ37023120
Taste cells in the gut and on the tongue. Their common, paraneuronal featuresQ37295486
Gut peptides in the control of food intakeQ37442631
G protein-coupled receptors: the inside storyQ37658605
Signaling by internalized G-protein-coupled receptors.Q37715118
Soybean beta 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells.Q39777797
Cholecystokinin secretion induced by beta-conglycinin peptone depends on Galphaq-mediated pathways in enteroendocrine cells.Q39903070
Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells.Q39952329
Protein hydrolysates induce CCK release from enteroendocrine cells and act as partial agonists of the CCK1 receptorQ40022161
Peptides derived from dolicholin, a phaseolin-like protein in country beans (Dolichos lablab), potently stimulate cholecystokinin secretion from enteroendocrine STC-1 cells.Q40072224
GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cellsQ40172892
The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis.Q40447183
Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells.Q40466661
Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cellsQ41061373
Characterization of the release of cholecystokinin from a murine neuroendocrine tumor cell line, STC-1.Q41472897
Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expressionQ42055042
Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormonesQ42285866
Cholecystokinin release from isolated canine epithelial cells in short-term cultureQ42467916
Expression of Na+/glucose co-transporter 1 (SGLT1) in the intestine of piglets weaned to different concentrations of dietary carbohydrate.Q43102749
Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners.Q43118700
Dietary protein peptic hydrolysates stimulate cholecystokinin release via direct sensing by rat intestinal mucosal cells.Q43822532
Satiety elicited by cholecystokinin in intact and vagotomized ratsQ44469872
Detection of sweet and umami taste in the absence of taste receptor T1r3.Q44517672
Glucose sensing in the intestinal epitheliumQ44537639
Canine gut receptors mediating pancreatic responses to luminal L-amino acidsQ44660723
Adaptive response of equine intestinal Na+/glucose co-transporter (SGLT1) to an increase in dietary soluble carbohydrate.Q46219933
The potency of dietary amino acids in elevating plasma cholecystokinin immunoreactivity in cats is related to amino acid hydrophobicityQ46369327
Synergistic effects of 5'-nucleotides on rat taste responses to various amino acidsQ48367295
Electrophysiological and behavioral studies on the taste of umami substances in the ratQ52237131
A novel peptide isolated from the leaves of Gymnema sylvestre--I. Characterization and its suppressive effect on the neural responses to sweet taste stimuli in the ratQ68331653
Trypsin suppression of pancreatic enzyme secretion. Differential effect on cholecystokinin release and the enteropancreatic reflexQ69569162
Significance of peptic digestion in rat pancreatic secretory response to dietary proteinQ71404589
Gurmarin inhibition of sweet taste responses in miceQ72199183
CholecystokininQ72433352
Role of endogenous CCK in the inhibition of gastric emptying by peptone and Intralipid in ratsQ73521132
Umami taste in mice uses multiple receptors and transduction pathwaysQ83066102
Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transportQ84060955
P433issue3
P304page(s)G271-82
P577publication date2012-11-29
P1433published inAmerican Journal of Physiology - Gastrointestinal and Liver PhysiologyQ15765756
P1476titleSensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion
P478volume304

Reverse relations

cites work (P2860)
Q34627506Activation of the umami taste receptor (T1R1/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon
Q38751167Amino acids regulate mTOR pathway and milk protein synthesis in a mouse mammary epithelial cell line is partly mediated by T1R1/T1R3.
Q47355283Arecoline Alters Taste Bud Cell Morphology, Reduces Body Weight, and Induces Behavioral Preference Changes in Gustatory Discrimination in C57BL/6 Mice
Q49511052Calcium Sensing Receptors Mediate Local Inhibitory Reflexes Evoked by L-Phenylalanine in Guinea Pig Jejunum
Q38824166Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell
Q36293850Clofibrate inhibits the umami-savory taste of glutamate
Q34172652Cross-species comparison of genes related to nutrient sensing mechanisms expressed along the intestine
Q88548591DNA Methylation of T1R1 Gene in the Vegetarian Adaptation of Grass Carp Ctenopharyngodon idella
Q47747114Distribution and characterisation of CCK containing enteroendocrine cells of the mouse small and large intestine.
Q27013742Duodenal luminal nutrient sensing
Q36201039Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial
Q49743454Evaluation of casein & whey protein hydrolysates as well as milk fermentates from Lactobacillus helveticus for expression of gut hormones.
Q48250090Expression profiling of Tas2r genes reveals a complex pattern along the mouse GI tract and the presence of Tas2r131 in a subset of intestinal Paneth cells
Q38086347Food and symptom generation in functional gastrointestinal disorders: physiological aspects
Q92786380Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism
Q39047697Ghrelin, CCK, GLP-1, and PYY(3-36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB.
Q58707940Glucagon-Like Peptide-2 and the Enteric Nervous System Are Components of Cell-Cell Communication Pathway Regulating Intestinal Na/Glucose Co-transport
Q90379245Integrated Remodeling of Gut-Liver Metabolism Induced by Moderate Protein Restriction Contributes to Improvement of Insulin Sensitivity
Q53662597Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice.
Q37169515L-arginine promotes gut hormone release and reduces food intake in rodents.
Q92177903L-phenylalanine Increased Gut Hormone Secretion through Calcium-Sensing Receptor in the Porcine Duodenum
Q26864827Minireview: Nutrient sensing by G protein-coupled receptors
Q86441804Monosodium L-glutamate in soup reduces subsequent energy intake from high-fat savoury food in overweight and obese women
Q34798276Mouse neutrophils express functional umami taste receptor T1R1/T1R3.
Q89892428Neuropod Cells: Emerging Biology of the Gut-Brain Sensory Transduction
Q36192799Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells.
Q97591821Nutrient sensing of gut luminal environment
Q26799380Pharmacology and physiology of gastrointestinal enteroendocrine cells
Q28085601Phytogenic compounds as alternatives to in-feed antibiotics: potentials and challenges in application
Q55039236Protein-induced satiation and the calcium-sensing receptor.
Q27322460Regulation of α-Transducin and α-Gustducin Expression by a High Protein Diet in the Pig Gastrointestinal Tract
Q92478526Responsiveness Expressions of Bitter Taste Receptors Against Denatonium Benzoate and Genistein in the Heart, Spleen, Lung, Kidney, and Bursa Fabricius of Chinese Fast Yellow Chicken
Q89554400Review: Nutritional regulation of intestinal starch and protein assimilation in ruminants
Q57490795Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control
Q46952441Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing
Q38947253Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells
Q26765259Stimulation of incretin secreting cells
Q92486022Taste and the Gastrointestinal tract: from physiology to potential therapeutic target for obesity
Q91801741Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a+ CD49b- natural killer cells
Q38153130Taste receptors of the gut: emerging roles in health and disease
Q28074753The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future
Q37126252The Macronutrients, Appetite, and Energy Intake.
Q47134827The Role of Cholecystokinin in Peripheral Taste Signaling in Mice
Q28354291The Sweetener-Sensing Mechanisms of the Ghrelin Cell
Q45894561The gut as a sensory organ.
Q90033679Therapeutic potential of ectopic olfactory and taste receptors
Q88664226Tuft cells: Distribution and connections with nerves and endocrine cells in mouse intestine
Q47602279Umami Increases Consumer Acceptability, and Perception of Sensory and Emotional Benefits without Compromising Health Benefit Perception
Q61815575Umami as an 'Alimentary' Taste. A New Perspective on Taste Classification
Q36257164Using Animal Models to Determine the Role of Gustatory Neural Input in the Control of Ingestive Behavior and the Maintenance of Body Weight
Q40692245Variations in TAS1R taste receptor gene family modify food intake and gastric cancer risk in a Korean population
Q38632450l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents