Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults

scientific article published on 29 November 2012

Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EMMM.201201398
P932PMC publication ID3569656
P698PubMed publication ID23197416
P5875ResearchGate publication ID233806155

P2093author name stringLawrence Chan
Benny Hung-Junn Chang
Yisheng Yang
P2860cites workMolecular regulation of pancreatic beta-cell mass development, maintenance, and expansionQ36733461
Glucolipotoxicity: fuel excess and beta-cell dysfunction.Q36861036
Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansionQ37214986
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and functionQ37238979
Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expressionQ37452586
Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.Q40051311
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretionQ40871524
IPF1, a homeodomain-containing transactivator of the insulin geneQ40874284
A murine model of neonatal diabetes mellitus in Glis3-deficient miceQ42454563
Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish peopleQ43085753
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.Q48087598
mRNA Profiling of Rat Islet Tumors Reveals Nkx 6.1 as a β-Cell-specific Homeodomain Transcription FactorQ56871535
Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoterQ73473642
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetesQ24632382
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskQ28270700
The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcriptionQ28507859
Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)Q28570676
GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functionsQ28591478
Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetesQ28744684
Pancreatic beta cells require NeuroD to achieve and maintain functional maturityQ28752551
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east AsiansQ29417142
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenumQ29618151
Insulin-promoter-factor 1 is required for pancreas development in miceQ29619695
Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodentsQ33750760
Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic ratsQ33757675
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growthQ33758338
Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese HansQ33957907
Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicityQ34109834
Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.Q34114554
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 childrenQ35043398
The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.Q35252235
Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetesQ35641724
Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreasQ35796459
Five stages of evolving beta-cell dysfunction during progression to diabetesQ35961960
Pancreatic beta cells express a diverse set of homeobox genesQ35967171
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptorsQ36056970
Molecular control of cell cycle progression in the pancreatic beta-cellQ36459964
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectcell functionQ95674809
P1104number of pages13
P304page(s)92-104
P577publication date2012-11-29
P1433published inEMBO Molecular MedicineQ15817279
P1476titleSustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults
P478volume5

Reverse relations

cites work (P2860)
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Q92256221ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes
Q90745613Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM
Q57915591An emerging, recognizable facial phenotype in association with mutations in GLI-similar 3 (GLIS3)
Q38134106Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis
Q51344557Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function.
Q58705850Discovering human diabetes-risk gene function with genetics and physiological assays
Q61136989Discovery of a drug candidate for GLIS3-associated diabetes
Q33726975Drosophila as a Model for Diabetes and Diseases of Insulin Resistance
Q35123257Elevation of NR4A3 expression and its possible role in modulating insulin expression in the pancreatic beta cell
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Q47588788GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation.
Q48596938GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus.
Q28571413GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim
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Q35683842HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.
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Q36960085Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes
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