| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1994PNAS...9112203R |
| P356 | DOI | 10.1073/PNAS.91.25.12203 |
| P932 | PMC publication ID | 45405 |
| P698 | PubMed publication ID | 7991607 |
| P5875 | ResearchGate publication ID | 15206849 |
| P2093 | author name string | A Rudnick | |
| M S German | |||
| W J Rutter | |||
| T Y Ling | |||
| H Odagiri | |||
| P2860 | cites work | Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain | Q24337900 |
| Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes | Q24561480 | ||
| Vertebrate homeobox gene nomenclature | Q28183710 | ||
| Isolation and chromosomal localization of the human En-2 gene | Q28256615 | ||
| Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain | Q28564170 | ||
| Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene | Q31171099 | ||
| Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin Enhancer | Q33263393 | ||
| A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer | Q33580583 | ||
| Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene | Q33679093 | ||
| Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex | Q34244863 | ||
| MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer | Q34245181 | ||
| Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells | Q34290753 | ||
| Drosophila NK-homeobox genes | Q34310185 | ||
| Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system. | Q34322302 | ||
| A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer | Q34375782 | ||
| Hormone-producing cultures of adrenal and pituitary tumor origin | Q36395632 | ||
| Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis | Q36721320 | ||
| Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequence | Q36755529 | ||
| Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene | Q36756394 | ||
| Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements | Q36758591 | ||
| Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cells | Q36764691 | ||
| Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription | Q36766829 | ||
| Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators | Q36790901 | ||
| Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins | Q36961228 | ||
| The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain | Q37608546 | ||
| IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene | Q37629612 | ||
| A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection | Q39532799 | ||
| Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes | Q40505363 | ||
| The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes | Q40678585 | ||
| Nutrient regulation of insulin gene expression. | Q40810524 | ||
| IPF1, a homeodomain-containing transactivator of the insulin gene | Q40874284 | ||
| Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain | Q41252832 | ||
| Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene | Q41665716 | ||
| Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells | Q41676218 | ||
| A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer | Q41849203 | ||
| Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice | Q42071188 | ||
| Isolation of glucagon-secreting cell lines by cloning insulinoma cells | Q42503444 | ||
| Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. | Q42601379 | ||
| Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression | Q42810408 | ||
| Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements | Q43524876 | ||
| En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis | Q46494637 | ||
| Sequence-specific interactions of nuclear factors with the insulin gene enhancer. | Q48366496 | ||
| P433 | issue | 25 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 5 | |
| P304 | page(s) | 12203-12207 | |
| P577 | publication date | 1994-12-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Pancreatic beta cells express a diverse set of homeobox genes | |
| P478 | volume | 91 |
| Q38782115 | A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells |
| Q36556612 | Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3. |
| Q41072029 | Alx-4: cDNA cloning and characterization of a novel paired-type homeodomain protein |
| Q34795261 | BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation |
| Q41734472 | Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains. |
| Q47713881 | Biallelic mutations in the homeodomain of NKX6-2 underlie a severe hypomyelinating leukodystrophy |
| Q55312695 | Changes of MODY signal pathway genes in the endoplasmic reticulum stress in INS-1-3 cells. |
| Q52179190 | Characterization of beta cells developed in vitro from rat embryonic pancreatic epithelium. |
| Q22010819 | Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1 |
| Q40755201 | Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma |
| Q33807012 | Comparative sequence analysis reveals regulation of genes in developing schistosomula of Schistosoma mansoni exposed to host portal serum |
| Q58091069 | Comparison of enteroendocrine cells and pancreatic β-cells using gene expression profiling and insulin gene methylation |
| Q48038312 | Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development |
| Q27011814 | Derivation of insulin-producing beta-cells from human pluripotent stem cells |
| Q37326969 | Developmental biology of the pancreas: a comprehensive review |
| Q39238595 | Differential configurations involving binding of USF transcription factors and Twist1 regulate Alx3 promoter activity in mesenchymal and pancreatic cells. |
| Q42425834 | Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination |
| Q43007453 | Expression and function of Nkx6.3 in vertebrate hindbrain. |
| Q36897024 | Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells |
| Q28570533 | Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation |
| Q33307051 | Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells |
| Q35029666 | Gene expression cascades in pancreatic development |
| Q53641488 | Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1. |
| Q26823732 | Generation of β cells from human pluripotent stem cells: are we there yet? |
| Q52108927 | Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. |
| Q48035174 | Homeobox gene product Nkx 6.1 immunoreactivity in nuclei of endocrine cells of rat and mouse stomach |
| Q40677580 | Identification of target genes for EWS/ATF-1 chimeric transcription factor. |
| Q82262573 | Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas |
| Q38317761 | Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells |
| Q35206578 | Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins |
| Q34734744 | Melatonin-receptor-1-deficiency affects neurogenic differentiation factor immunoreaction in pancreatic islets and enteroendocrine cells of mice |
| Q47919111 | Munster, a novel paired-class homeobox gene specifically expressed in the Drosophila larval eye. |
| Q36864408 | NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition |
| Q40419554 | NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor. |
| Q34574951 | Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity |
| Q37234161 | On the origin of the beta cell |
| Q28577175 | POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element |
| Q47932670 | Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice |
| Q73301463 | Pax4 regulatory elements mediate beta cell specific expression in the pancreas |
| Q22337236 | Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene |
| Q34460457 | Programming of the pancreas |
| Q28570676 | Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1) |
| Q48152535 | Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis byNkx6.1homeodomain transcription factor |
| Q28578166 | Regulated expression of the homeobox gene, rPtx2, in the developing rat |
| Q40429175 | Relative contribution of PDX-1, MafA and E47/beta2 to the regulation of the human insulin promoter |
| Q28507588 | Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum |
| Q36574278 | Specificity of four monoclonal anti-NKx6-1 antibodies |
| Q37416022 | Stem cell therapy to treat diabetes mellitus |
| Q24641935 | Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1 |
| Q36602173 | Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults |
| Q30499855 | The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors |
| Q28583176 | The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription |
| Q36831512 | The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells |
| Q39450757 | The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter |
| Q31812556 | The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation. |
| Q38322223 | The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS. |
| Q28118770 | The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity |
| Q38995270 | The study of regulatory effects of Pdx-1, MafA and NeuroD1 on the activity of porcine insulin promoter and the expression of human islet amyloid polypeptide |
| Q24307633 | The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression |
| Q40850468 | Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression |
| Q28589257 | Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1 |
| Q35185531 | Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function. |
| Q56871535 | mRNA Profiling of Rat Islet Tumors Reveals Nkx 6.1 as a β-Cell-specific Homeodomain Transcription Factor |
| Q24679135 | rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina |
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