A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes

scientific article published on 24 February 2016

A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1001985021
P356DOI10.1186/S12940-016-0120-5
P932PMC publication ID4765217
P698PubMed publication ID26911440
P5875ResearchGate publication ID295830754

P50authorNino KünzliQ37830519
Arnold von EckardsteinQ41607665
Nicole Probst-HenschQ41608191
Medea ImbodenQ41609052
Ikenna C EzeQ56786688
P2093author name stringFlorian Kronenberg
Ashish Kumar
Christian Schindler
Daiana Stolz
Margaret W Gerbase
Martin Adam
Alexander Turk
P2860cites workEpigenetics: a molecular link between environmental factors and type 2 diabetesQ24652830
PLINK: a tool set for whole-genome association and population-based linkage analysesQ24677407
Induction of proinflammatory cytokines and C-reactive protein in human macrophage cell line U937 exposed to air pollution particulatesQ24810839
Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetesQ26823288
Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studiesQ27000990
Epidemiological and experimental links between air pollution and type 2 diabetesQ27005291
Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanismsQ27348345
Gene-air pollution interaction and cardiovascular disease: a reviewQ28387703
Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysisQ28393346
Particulate matter from Saudi Arabia induces genes involved in inflammation, metabolic syndrome and atherosclerosisQ28652135
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultationQ29547453
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitusQ29619398
IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studiesQ31062623
Detection of genotyping errors by Hardy-Weinberg equilibrium testing.Q33197920
Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysisQ33740705
Association between source-specific particulate matter air pollution and hs-CRP: local traffic and industrial emissionsQ33841007
Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variabilityQ34061785
Environmental tobacco smoke exposure and diabetes in adult never-smokersQ34318445
Interleukin-6 and diabetes: the good, the bad, or the indifferent?Q34469909
Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).Q34973466
Increased methylation of interleukin 6 gene is associated with obesity in Korean womenQ35644482
Long-Term Exposure to Ambient Air Pollution and Metabolic Syndrome in AdultsQ35672063
Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the Multi-Ethnic Study of Atherosclerosis (MESA)Q35684021
Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohortQ35773720
Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollutionQ35776593
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathwayQ35995696
Characterization of source-specific air pollution exposure for a large population-based Swiss cohort (SAPALDIA)Q36130874
Air pollution and type 2 diabetes: mechanistic insightsQ36410657
Chronic residential exposure to particulate matter air pollution and systemic inflammatory markersQ37291896
Modification of the interleukin-6 response to air pollution by interleukin-6 and fibrinogen polymorphismsQ37331167
A Swiss neighbourhood index of socioeconomic position: development and association with mortalityQ37548581
Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE reviewQ37845992
Land use regression models for crustal and traffic-related PM2.5 constituents in four areas of the SAPALDIA studyQ38862734
Long-term air pollution exposure and diabetes in a population-based Swiss cohortQ38996930
Association between IL6 gene variants -174G>C and -572G>C and serum IL-6 levels: interactions with social position in the Whitehall II cohortQ40026631
Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam StudyQ40603438
Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgeryQ40686433
Air pollution particles induce IL-6 gene expression in human airway epithelial cells via NF-kappaB activationQ41028807
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytesQ42805075
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone.Q42834547
Association between the interleukin-6 gene -572 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 11,681 subjectsQ43680991
Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysisQ44179007
Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass indexQ46046292
Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants.Q46707102
The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitusQ46833522
Interleukin-6 CpG Methylation and Body Weight Correlate Differently in Type 2 Diabetes Patients Compared to Obese and Lean ControlsQ47381485
Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis.Q53202650
Effects of PM2.5 collected from Cache Valley Utah on genes associated with the inflammatory response in human lung cells.Q53526231
Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.Q53874538
SAPALDIA: Methods and participation in the cross-sectional part of the Swiss Study on Air Pollution and Lung Diseases in AdultsQ57010370
Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitroQ68927133
Genetic variants of IL6 gene promoter influence on C-reactive protein levels but are not associated with susceptibility to invasive pulmonary aspergillosis in haematological patientsQ80484194
P304page(s)39
P577publication date2016-02-24
P1433published inEnvironmental HealthQ15733766
P1476titleA common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes
P478volume15

Reverse relations

cites work (P2860)
Q64098239A Cell-Based Approach to Study the Associations Between Mitochondrial Health, Early Life Exposures, and Consequent Health Outcomes
Q48042433Association between PM10, PM2.5, NO2, O3 and self-reported diabetes in Italy: A cross-sectional, ecological study
Q92238794Association of Polymorphisms in miRNA Processing Genes With Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population
Q90341857Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution
Q38879494Long-term exposure to transportation noise and air pollution in relation to incident diabetes in the SAPALDIA study
Q99609880Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study
Q60919637genetic diversity and plasma IL6 levels in bipolar disorder: An Indo-French study

Search more.