Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy

scientific article published on 5 November 2012

Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/CB300460F
P932PMC publication ID3574219
P698PubMed publication ID23102022

P2093author name stringYunfang Li
David L Hermanson
Chengguo Xing
Ameeta Kelekar
Nicholas Bleeker
Sonia G Das
Xazmin Lowman
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Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analoguesQ39502559
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analoguesQ39801240
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Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store contentQ44570171
A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia.Q46183389
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Displacement of SERCA from SR lipid caveolae-related domains by Bcl-2: a possible mechanism for SERCA inactivationQ46875789
High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia.Q52530287
The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells.Q53194732
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Five putative drug resistance parameters (MDR1/P-glycoprotein, MDR-associated protein, glutathione-S-transferase, bcl-2 and topoisomerase IIalpha) in 57 newly diagnosed acute myeloid leukaemias. Swiss Group for Clinical Cancer Research (SAKK)Q73807506
MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patientsQ74710902
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P433issue2
P921main subjectmultiple drug resistanceQ643839
chemotherapyQ974135
P304page(s)327-335
P577publication date2012-11-05
P1433published inACS Chemical BiologyQ165583
P1476titleEthyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy
P478volume8

Reverse relations

cites work (P2860)
Q389093644H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions
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Q58200651Indium triflate catalyzed microwave-assisted alkenylation of methoxyphenols: synthesis of indenes and chromenes
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Q33763765Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance

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