Interleukins and STAT signaling

scientific article published on January 2006

Interleukins and STAT signaling is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0083-6729(06)74007-9
P698PubMed publication ID17027515

P2093author name stringPankaj Sharma
S Jaharul Haque
P2860cites workThe Janus kinases (Jaks)Q21194856
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cellsQ22009002
Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursorsQ22254187
Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22RQ22254431
Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domainQ24290190
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12Q24290619
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signallingQ24290848
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23RQ24297906
Identification of a nuclear Stat1 protein tyrosine phosphataseQ24302061
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathwayQ24305237
Requirements for interleukin-4-induced gene expression and functional characterization of Stat6Q24308078
cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3Q24309161
Inhibition of Stat1-mediated gene activation by PIAS1Q24310082
Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.Q54118063
Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation.Q54258378
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.Q55066450
Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2Q57054898
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitroQ57055052
A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130Q57272697
Structural comparisons among the short-chain helical cytokinesQ57904799
Identification of Critical Residues Required for Suppressor of Cytokine Signaling-specific Regulation of Interleukin-4 SignalingQ58666184
Roles of Protein-tyrosine Phosphatases in Stat1 -mediated Cell SignalingQ58666537
STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells.Q64968569
Distribution of the mammalian Stat gene family in mouse chromosomesQ70807902
Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathwayQ71468319
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3Q71542082
Defective lymphoid development in mice lacking Jak3Q71542089
Localization of genes for two members of the JAK family of protein tyrosine kinases to murine chromosomes 4 and 19Q71882789
Immune response in Stat2 knockout miceQ73406523
The mechanism of IL-5 signal transductionQ77217607
Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophilsQ77584426
Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytesQ77659000
Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient miceQ77725481
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasisQ78836958
A peek at PIASQ80501651
Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chainsQ24310724
Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cellsQ24311526
A family of cytokine-inducible inhibitors of signallingQ24313168
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytesQ24313200
A new protein containing an SH2 domain that inhibits JAK kinasesQ24313242
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinaseQ24314333
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesisQ24316448
Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptorQ24317719
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transductionQ24319109
IL-28, IL-29 and their class II cytokine receptor IL-28RQ24323830
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNAQ24336371
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complexQ24336912
Principles of interleukin (IL)-6-type cytokine signalling and its regulationQ24530173
Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3Q24535580
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.Q24537294
Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbetaQ24538513
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiationQ24538645
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transductionQ24564242
JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal regionQ24612039
Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory regionQ24628753
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylationQ24644334
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationQ24654107
Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transductionQ24654170
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethalityQ24685515
Crystal structure of the tyrosine kinase domain of the human insulin receptorQ27730800
Three-dimensional structure of the Stat3beta homodimer bound to DNAQ27764842
The protein kinase family: conserved features and deduced phylogeny of the catalytic domainsQ27860528
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
How cells respond to interferonsQ27861006
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcriptionQ33938819
Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexesQ33941385
Serine phosphorylation of STATsQ33941422
Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family.Q33943220
Signaling by type I and II cytokine receptors: ten years afterQ33951373
Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liverQ33967216
Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1Q34065588
Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alphaQ34086377
Cytokine signaling in 2002: new surprises in the Jak/Stat pathwayQ34126053
The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functionsQ34146819
Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functionsQ34152063
The Stat family in cytokine signalingQ34180677
Decoy receptors: a strategy to regulate inflammatory cytokines and chemokinesQ34264032
Inhibitors of cytokine signal transductionQ34275568
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cellsQ34388169
Genomic sequence, organization, and chromosomal localization of human JAK3.Q34407583
New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway.Q34412332
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responsesQ34468309
The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responsesQ34468846
Cytokines and immunodeficiency diseasesQ34572193
Stat1-dependent and -independent pathways in IFN-gamma-dependent signalingQ34584978
JAK-STAT signaling in asthmaQ34647024
A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5Q34662194
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factorQ34679479
Cytokine and cytokine receptor pleiotropy and redundancyQ34693494
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.Q34759631
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunityQ34762373
CD45: a critical regulator of signaling thresholds in immune cellsQ34987899
An epigenetic view of helper T cell differentiationQ35164202
Molecular phylogeny within type I cytokines and their cognate receptorsQ35204511
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.Q35207498
Lineage-specific negative regulation of STAT-mediated signaling by proteolytic processingQ35209134
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat familiesQ35211894
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Q28637521
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expressionQ28638072
Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two typesQ28638350
Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteinsQ28645718
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding proteinQ28646262
STATs and gene regulationQ29547796
The STATs of cancer--new molecular targets come of ageQ29614601
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral diseaseQ29615967
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathwayQ29615968
Active and inactive protein kinases: structural basis for regulationQ29616320
Structural design and molecular evolution of a cytokine receptor superfamilyQ29618154
Jaks and STATs: biological implicationsQ29619657
Transcriptional responses to polypeptide ligands: the JAK-STAT pathwayQ29620287
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.Q33183255
Negative regulation of the JAK/STAT pathwayQ33539658
Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradationQ33559005
The STAT family of proteins in cytokine signalingQ33650629
Negative regulation of NF-kappaB signaling by PIAS1.Q33714545
Cytokines and JAK-STAT signalingQ33783480
Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexesQ33921809
Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell functionQ33924665
A protein tyrosine kinase in the interferon alpha/beta signaling pathwayQ28116574
IL-4/IL-13 signaling beyond JAK/STATQ28138418
Gigantism in mice lacking suppressor of cytokine signalling-2Q28140549
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) inductionQ28140805
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethalityQ28144528
SOCS3 is essential in the regulation of fetal liver erythropoiesisQ28144536
The IL-4 receptor: signaling mechanisms and biologic functionsQ28198739
PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4Q28201360
The SOCS box: a tale of destruction and degradationQ28205975
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interactionQ28208174
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130Q28211408
TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expressionQ28211551
Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signalingQ28214491
Novel interferonsQ28218804
Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2Q28242524
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cellsQ28244421
Interleukin-10 and related cytokines and receptorsQ28251518
STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.Q28253106
Specific inhibition of Stat3 signal transduction by PIAS3Q28255665
Cytokine signal transductionQ28258951
Regulation of gene-activation pathways by PIAS proteins in the immune systemQ28264801
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in miceQ28265772
Characterization of the signaling capacities of the novel gp130-like cytokine receptorQ28266811
Jak2 is essential for signaling through a variety of cytokine receptorsQ28270987
Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridizationQ28272253
Essential role of Stat6 in IL-4 signallingQ28276199
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 geneQ28276209
A Novel Sequence in the Coiled-coil Domain of Stat3 Essential for Its Nuclear TranslocationQ28505954
Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epitheliumQ28513906
Structure and function of a new STAT-induced STAT inhibitorQ28584775
Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanismQ28585612
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transductionQ28588105
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responsesQ28592023
Interleukin 20: discovery, receptor identification, and role in epidermal functionQ28593930
Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction.Q40988710
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient miceQ41185362
Elucidation of the basic three-dimensional structure of type I interferons and its functional and evolutionary implications.Q41511507
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathwayQ41514580
Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6.Q41595593
Interferon-alpha activates binding of nuclear factors to a sequence element in the c-fos proto-oncogene 5'-flanking regionQ41600016
Shared architecture of hormone binding domains in type I and II interferon receptorsQ42630904
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesisQ42679964
Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clonesQ42767900
Characterization of the Stat5 proteaseQ42811119
Roles of the cytoplasmic domains of the alpha and beta subunits of human granulocyte-macrophage colony-stimulating factor receptor.Q42819905
Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activityQ43814564
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.Q44021327
Components of a Stat recognition code: evidence for two layers of molecular selectivityQ44747920
Cell signaling. Stat acetylation--a key facet of cytokine signaling?Q45226467
PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.Q46006991
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophagesQ46376203
Jak3 maps to chromosome 8.Q46548131
PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cellsQ46592704
Stat5a is mandatory for adult mammary gland development and lactogenesis.Q48055024
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) geneQ48111435
The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5.Q51085641
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.Q52174469
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.Q52204302
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.Q52537943
Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival.Q52543788
Virtual gating and nuclear transport: the hole pictureQ35587487
Regulation of JAK-STAT signalling in the immune systemQ35605437
Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.Q35626895
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune responseQ35698515
A new modality for immunosuppression: targeting the JAK/STAT pathwayQ35825869
Mechanisms of soluble cytokine receptor generationQ35923165
DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1.Q35967250
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP.Q36076075
STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cellsQ36161667
Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1Q36351256
The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasisQ36376720
Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus productionQ36400465
Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient miceQ36400723
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent miceQ36497106
Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1.Q36548039
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signalingQ36638911
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expressionQ36653664
Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinasesQ36745947
Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.Q36813436
Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiationQ37493064
Haemopoietic receptors and helical cytokinesQ37895794
Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factorQ38287574
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisQ38290076
Leptin activates Stat3, Stat1 and AP-1 in mouse adipose tissueQ38306983
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 geneQ38309989
SOCS3 regulates the plasticity of gp130 signalingQ38354507
SOCS3 negatively regulates IL-6 signaling in vivoQ38354512
Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cellsQ38359739
STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cellsQ39122429
Regulation of Stat3 nuclear exportQ39741143
Serine phosphorylation of Stat6 negatively controls its DNA-binding functionQ40369583
Cytokine receptor signallingQ40416594
Alpha and beta interferons and their receptor and their friends and relations.Q40467356
Dimerization of cell surface receptors in signal transductionQ40579106
Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.Q40609503
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cellsQ40685493
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nucleiQ40701903
IL-4 induces the proteolytic processing of mast cell STAT6.Q40702315
Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3.Q40764229
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.Q40816941
The type-I interferon receptor. The long and short of it.Q40931099
P304page(s)165-206
P577publication date2006-01-01
P1433published inVitamins and HormonesQ15753296
P1476titleInterleukins and STAT signaling
P478volume74

Reverse relations

cites work (P2860)
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