Beyond antigens and adjuvants: formulating future vaccines

scientific article published on March 2016

Beyond antigens and adjuvants: formulating future vaccines is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI81083
P932PMC publication ID4767337
P698PubMed publication ID26928033

P2093author name stringDarrell J Irvine
Tyson J Moyer
Andrew C Zmolek
P2860cites workVaccine adjuvant activity of 3M-052: an imidazoquinoline designed for local activity without systemic cytokine inductionQ84276325
The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvantQ84634230
Delivery of polysaccharides using polymer particles: implications on size-dependent immunogenicity, opsonophagocytosis, and protective immunityQ43700368
Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administrationQ43888679
In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles.Q44490370
Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transportQ44591257
Synthetic virus-like particles from self-assembling coiled-coil lipopeptides and their use in antigen display to the immune systemQ45399710
Nanoparticles target distinct dendritic cell populations according to their sizeQ45732404
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells.Q46017170
Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trialQ46623264
Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid compostion and lipid doseQ47301856
Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumorsQ47409832
The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the folliclesQ48914128
Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205.Q50457532
Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response.Q50560920
Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.Q50768287
A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening.Q51533158
Liposome-encapsulated HIV-1 Gag p24 containing lipid A induces effector CD4+ T-cells, memory CD8+ T-cells, and pro-inflammatory cytokines.Q51890485
CD8 T cell expansion and memory differentiation are facilitated by simultaneous and sustained exposure to antigenic and inflammatory milieu.Q51968169
Molecular signature of CD8+ T cell exhaustion during chronic viral infection.Q51970485
PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration.Q53076908
Activating B Cell Signaling with Defined Multivalent LigandsQ56656698
Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper functionQ56880717
Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI responseQ57955486
Toll-dependent selection of microbial antigens for presentation by dendritic cellsQ59063722
Control of B-cell responses by Toll-like receptorsQ59066168
The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated SignalingQ63409208
The influence of antigen organization on B cell responsivenessQ72628042
Regulation of IgG antibody responses by epitope density and CD21-mediated costimulationQ78852123
B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph nodeQ80688189
Exploiting lymphatic transport and complement activation in nanoparticle vaccinesQ81305052
Innate immunity mediates follicular transport of particulate but not soluble protein antigenQ83684751
Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of ageQ24658073
Vaccine Adjuvants: from 1920 to 2015 and BeyondQ26783879
Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in miceQ28486624
Differential antigen processing by dendritic cell subsets in vivoQ29615177
Programming the magnitude and persistence of antibody responses with innate immunityQ30400144
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodiesQ30430925
Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infectionQ30433900
Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccineQ30585157
A self-assembling peptide acting as an immune adjuvantQ33640064
Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.Q33760871
Structure-based programming of lymph-node targeting in molecular vaccinesQ33800766
Inflammatory cytokines as a third signal for T cell activationQ33936084
Localization dose and time of antigens determine immune reactivityQ33980378
Dissolving polymer microneedle patches for influenza vaccinationQ34049972
HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primatesQ34085119
Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell inductionQ34127442
Antigen depot is not required for alum adjuvanticityQ34235031
In vivo distribution of radioactivity in mice after injection of biodegradable polymer microspheres containing 14C-labeled tetanus toxoidQ34413177
Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation.Q34480372
Antibody persistence and T-cell balance: two key factors confronting HIV vaccine developmentQ34480617
Capturing complex 3D tissue physiology in vitroQ34565076
GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectivesQ34655188
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responsesQ34802680
Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.Q34875973
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological toleranceQ34985424
Molecular determinants of immunogenicity: the immunon model of immune responseQ35031292
Duration of antigen availability influences the expansion and memory differentiation of T cellsQ35175877
Antigen expression determines adenoviral vaccine potency independent of IFN and STING signalingQ35183935
Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose.Q37377550
A dual TLR agonist adjuvant enhances the immunogenicity and protective efficacy of the tuberculosis vaccine antigen ID93.Q37431320
Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccinationQ37603557
Materials engineering for immunomodulationQ37639157
Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaquesQ37643792
Identification of immune factors regulating antitumor immunity using polymeric vaccines with multiple adjuvantsQ37649282
Vaccine delivery: a matter of size, geometry, kinetics and molecular patternsQ37800358
The long-term potential of biodegradable poly(lactide-co-glycolide) microparticles as the next-generation vaccine adjuvantQ37956385
Boosting antibody responses by targeting antigens to dendritic cellsQ37966312
Alum adjuvant: some of the tricks of the oldest adjuvantQ37969028
The mechanism of action of MF59 - an innately attractive adjuvant formulationQ38017390
Accelerating next-generation vaccine development for global disease preventionQ38110775
Key roles of adjuvants in modern vaccinesQ38169040
Development and function of dendritic cell subsetsQ38212449
Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunizationQ38257857
The potency of the adjuvant, CpG oligos, is enhanced by encapsulation in PLG microparticlesQ38299407
Polymer multilayer tattooing for enhanced DNA vaccinationQ38499608
Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotypeQ39180411
Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responsesQ39398295
In situ regulation of DC subsets and T cells mediates tumor regression in miceQ39885761
Infection-mimicking materials to program dendritic cells in situQ39896570
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cellsQ40068378
Covalently coupled immunostimulant heterodimers.Q40459615
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicityQ40937108
Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolinesQ40998064
Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccinationQ41213216
Conduits mediate transport of low-molecular-weight antigen to lymph node folliclesQ41291427
Vaccine adjuvant MF59 promotes retention of unprocessed antigen in lymph node macrophage compartments and follicular dendritic cellsQ41582364
A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in humanQ41630579
Rational design of small molecules as vaccine adjuvants.Q41655108
Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in miceQ41695957
Dissolving microneedle delivery of nanoparticle-encapsulated antigen elicits efficient cross-priming and Th1 immune responses by murine Langerhans cellsQ41730559
A single-step immunization by sustained antigen releaseQ41741707
Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles loaded with protein antigenQ42221772
Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center responseQ42227086
Development and clinical study of a self-dissolving microneedle patch for transcutaneous immunization deviceQ43630592
Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticityQ43638130
TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathwayQ35220395
In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particlesQ35229225
Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccinationQ35518723
Contributions of humoral and cellular immunity to vaccine-induced protection in humans.Q35615024
Persistent antigen presentation after acute vesicular stomatitis virus infectionQ35635383
Immunological mechanisms of vaccinationQ35659533
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center inductionQ35709003
Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants.Q35836140
Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trialQ35925829
Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo.Q36022467
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factorQ36082833
Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitopeQ36083687
RETRACTED: Stabilization of vaccines and antibiotics in silk and eliminating the cold chainQ36132649
Microneedles for drug and vaccine deliveryQ36164749
Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodiesQ36167475
Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiationQ36228608
Prolonged persistence of measles virus RNA is characteristic of primary infection dynamicsQ36236209
Triggering TLR signaling in vaccinationQ36323399
HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.Q36345558
Virus-like display of a neo-self antigen reverses B cell anergy in a B cell receptor transgenic mouse modelQ36383391
Antigen kinetics determines immune reactivityQ36516144
Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patientsQ36547213
Engineered lentivector targeting of dendritic cells for in vivo immunizationQ36629181
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse virusesQ36693991
Designing tomorrow's vaccinesQ36730618
Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.Q36766872
Dendritic-cell immunotherapy: from ex vivo loading to in vivo targetingQ36939901
Nanoparticles and microparticles as vaccine-delivery systemsQ36968297
Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunityQ37103959
TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitisQ37120117
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cellsQ37139993
Toward an AIDS vaccineQ37158259
A self-adjuvanting supramolecular vaccine carrying a folded protein antigenQ37280623
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)799-808
P577publication date2016-03-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleBeyond antigens and adjuvants: formulating future vaccines
P478volume126

Reverse relations

cites work (P2860)
Q64285619A Magnetic Nanovaccine Enhances Cancer Immunotherapy
Q64056348A Recombinant Enolase-Montanide™ PetGel A Vaccine Promotes a Protective Th1 Immune Response against a Highly Virulent by Toluene Exposure
Q47573396A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination
Q37587612Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate
Q46205951Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy.
Q29248341Allergic Responses Induced by the Immunomodulatory Effects of Nanomaterials upon Skin Exposure
Q89497822Application of some nanoparticles in the field of veterinary medicine
Q90928865Biomaterial-assisted targeted modulation of immune cells in cancer treatment
Q47110564Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles
Q41987534Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates
Q92136067Chemical Modulation of Bioengineered Exosomes for Tissue-Specific Biodistribution
Q58575827Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4 T Cell-Independent CD8 T-Cell Response Against Unconjugated Protein Antigen
Q41684063Co-delivery of Dual Toll-Like Receptor Agonists and Antigen in Poly(Lactic-Co-Glycolic) Acid/Polyethylenimine Cationic Hybrid Nanoparticles Promote Efficient In Vivo Immune Responses.
Q99635480Combining therapeutic vaccines with chemo- and immunotherapies in the treatment of cancer
Q92350341Cricket paralysis virus internal ribosome entry site-derived RNA promotes conventional vaccine efficacy by enhancing a balanced Th1/Th2 response
Q39330984Delivering safer immunotherapies for cancer
Q40077299Dendritic cell and antigen dispersal landscapes regulate T cell immunity
Q92995626Dendritic cells in cancer immunology and immunotherapy
Q89748751Engineered immunogen binding to alum adjuvant enhances humoral immunity
Q39230209Engineering self-assembled materials to study and direct immune function
Q58767527Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10
Q58589975Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes
Q90182956Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
Q92276339Evaluation of a Recombinant Mouse X Pig Chimeric Anti-Porcine DEC205 Antibody Fused with Structural and Nonstructural Peptides of PRRS Virus
Q90696470First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
Q90251494Harnessing albumin as a carrier for cancer therapies
Q92051245High Molecular Weight Chitosan-Complexed RNA Nanoadjuvant for Effective Cancer Immunotherapy
Q92123879High-resolution 3D imaging and topological mapping of the lymph node conduit system
Q99201268How can nanotechnology help to combat COVID-19? Opportunities and urgent need
Q39198568Immunological effects of a novel RNA-based adjuvant in liver cancer patients
Q92886110Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy
Q89766256Intratumoral immunotherapy for early stage solid tumors
Q92557852Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses
Q93052117Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus
Q48630939Modulating the immune system through nanotechnology.
Q37633417Native-like Env trimers as a platform for HIV-1 vaccine design
Q26752546New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza
Q92859858Outflanking immunodominance to target subdominant broadly neutralizing epitopes
Q51161865Overcoming formulation challenges for the next generation of vaccines.
Q40050352Pathogen-mimicking vaccine delivery system designed with a bioactive polymer (inulin acetate) for robust humoral and cellular immune responses.
Q92239595Poly-γ-Glutamic Acid Complexed With Alum Induces Cross-Protective Immunity of Pandemic H1N1 Vaccine
Q30400146Poly-γ-glutamic acid/chitosan nanogel greatly enhances the efficacy and heterosubtypic cross-reactivity of H1N1 pandemic influenza vaccine
Q48504993Pregnancy and infection: using disease pathogenesis to inform vaccine strategy
Q93150667Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms
Q90334800Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization
Q39183386Recent progress in GM-CSF-based cancer immunotherapy
Q93052085Recombinant Influenza Vaccines: Saviors to Overcome Immunodominance
Q45324844Reply to "Highly Efficacious Novel Vaccine, Humoral Immunity, and Ocular Herpes Simplex Virus 1: Reality or Myth?"
Q64073304Role of Linker Length and Antigen Density in Nanoparticle Peptide Vaccine
Q90628348Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity
Q90568060Shaping humoral immunity to vaccines through antigen-displaying nanoparticles
Q64091060SnoopLigase peptide-peptide conjugation enables modular vaccine assembly
Q92803580Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates
Q52643675Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human Antibodies.
Q41718977Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle Uptake and Delivery
Q37379662Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination
Q55379719TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25.
Q99711565Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice
Q100466517Technological approaches to streamline vaccination schedules, progressing towards single-dose vaccines
Q39298187The Hen's Egg Test on Chorioallantoic Membrane: An Alternative Assay for the Assessment of the Irritating Effect of Vaccine Adjuvants.
Q58803479The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery
Q33710401The Use of Xanthan Gum as Vaccine Adjuvant: An Evaluation of Immunostimulatory Potential in BALB/c Mice and Cytotoxicity In Vitro
Q99413714The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems
Q100526249Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen
Q97420836Toll-Like Receptor Ligand Based Adjuvant, PorB, Increases Antigen Deposition on Germinal Center Follicular Dendritic Cells While Enhancing the Follicular Dendritic Cells Network
Q92434451Toward precision adjuvants: optimizing science and safety
Q37365222Towards the knowledge-based design of universal influenza epitope ensemble vaccines
Q58746739Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy
Q52848957Vaccination with trifunctional nanoparticles that address CD8+ dendritic cells inhibits growth of established melanoma.
Q95322966Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy
Q91168571Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection