TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25.

scientific article

TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.120692
P932PMC publication ID6012510
P698PubMed publication ID29769448

P50authorPatrick Emmet DuffyQ7146446
David L. NarumQ55174557
Michal JuraskaQ56776179
Sebastian OlsQ56776192
Kazutoyo MiuraQ66876252
Carole A LongQ66908908
Kelly M. RauschQ114406011
P2093author name stringMats Spångberg
Elizabeth A Thompson
Lloyd Johnston
Randall F Howard
Karin Loré
Ulrike Wille-Reece
Conlin P O'Neil
Amy Weiner
P2860cites workMechanisms that determine plasma cell lifespan and the duration of humoral immunity.Q37773425
Phenotype and functions of memory Tfh cells in human bloodQ38226748
Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell ResponsesQ38349570
The march toward malaria vaccinesQ38577638
Non-human primates as a model for understanding the mechanism of action of toll-like receptor-based vaccine adjuvants.Q39439099
Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive MacaquesQ40077472
Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake.Q40180898
Systems analysis of protective immune responses to RTS,S malaria vaccination in humansQ40334346
Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infectionQ40681333
Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper FunctionsQ40822910
Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cellsQ44471210
Duration of humoral immunity to common viral and vaccine antigensQ45872621
Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells.Q47112853
Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cellsQ47875310
Reference values of clinical chemistry and hematology parameters in rhesus monkeys (Macaca mulatta).Q53752989
IFN-alpha/beta enhances BCR-dependent B cell responsesQ77885633
Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulationQ85052394
Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPsQ89777595
Advances and challenges in malaria vaccine developmentQ21032463
Self-assembling protein nanoparticles in the design of vaccinesQ26767097
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humansQ29616204
Programming the magnitude and persistence of antibody responses with innate immunityQ30400144
Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51.Q33350210
Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.Q33760871
Development of a Pfs25-EPA malaria transmission blocking vaccine as a chemically conjugated nanoparticleQ34341570
Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunizationQ34509612
Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assaysQ34618434
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological toleranceQ34985424
Vaccine-induced plasmablast responses in rhesus macaques: phenotypic characterization and a source for generating antigen-specific monoclonal antibodiesQ35071821
Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complexQ35132063
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center inductionQ35709003
Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primatesQ35849215
Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman PrimatesQ35864569
Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve AdultsQ36165265
Translating innate immunity into immunological memory: implications for vaccine developmentQ36404657
Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technologyQ36442817
Competence and competition: the challenge of becoming a long-lived plasma cellQ36594883
Beyond antigens and adjuvants: formulating future vaccinesQ36618500
CXCL13 is a plasma biomarker of germinal center activityQ36684710
Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccinationQ36752092
TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitisQ37120117
Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum InfectionQ37371463
Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env TrimerQ37482035
Central Role of CD169+ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01.Q37519354
Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidateQ37587612
Molecular signatures of antibody responses derived from a systems biology study of five human vaccinesQ37625332
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responsesQ37718722
P433issue10
P921main subjectmalariaQ12156
nanoparticleQ61231
toll-like receptorQ408004
malaria vaccineQ6741353
P577publication date2018-05-17
P1433published inJCI insightQ27727187
P1476titleTLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25.
P478volume3

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cites work (P2860)
Q96137025A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates
Q57295570A plug-and-play approach for malaria vaccination
Q90699157Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment
Q92710260BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications
Q58120027Correlates of GLA family adjuvants' activities
Q92234270ELISA units, IgG subclass ratio and avidity determined functional activity of mouse anti-Pfs230 antibodies judged by a standard membrane-feeding assay with Plasmodium falciparum
Q92001627Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites
Q64359404Peripheral follicular helper T cells in acute viral diseases: a perspective on dengue
Q90261682Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25
Q56337913Progress toward a transmission-blocking vaccine against malaria
Q90628348Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity
Q90568060Shaping humoral immunity to vaccines through antigen-displaying nanoparticles
Q84315417Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

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