Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster

scientific article published on 8 May 2012

Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012NatCo...3..818B
P356DOI10.1038/NCOMMS1826
P932PMC publication ID3576573
P698PubMed publication ID22569366
P5875ResearchGate publication ID224925332

P50authorAchim BreilingQ42721275
Frank LykoQ56168094
Francesca TuortoQ56447551
P2093author name stringGünter Raddatz
Tanja Musch
Feng-Chun Yang
Mingjiang Xu
Michael T Bocker
P2860cites workTissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediatesQ21089989
Ultrafast and memory-efficient alignment of short DNA sequences to the human genomeQ21183894
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brainQ22065852
Core transcriptional regulatory circuitry in human embryonic stem cellsQ24322016
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineQ24614582
Genome-scale DNA methylation maps of pluripotent and differentiated cellsQ24621431
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAQ24632387
HOX gene activation by retinoic acidQ36542631
Retinoids regulate stem cell differentiationQ37788067
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genesQ39439009
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genomeQ39540112
Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA clusterQ40191181
Assessment of pluripotency and multilineage differentiation potential of NTERA-2 cells as a model for studying human embryonic stem cellsQ40207731
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cellsQ40212715
Colinearity and functional hierarchy among genes of the homeotic complexesQ40646505
Sequencing of natural strains of Arabidopsis thaliana with short readsQ41346495
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cellsQ41960997
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylationQ42239046
Methylated DNA immunoprecipitation (MeDIP).Q46261717
The dynamic architecture of Hox gene clusters.Q51850845
Retinoic acid and homeobox gene regulation.Q52215432
Human DNA methylomes at base resolution show widespread epigenomic differencesQ24633677
Retinoic acid synthesis and signaling during early organogenesisQ24642848
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shoresQ24649374
A bivalent chromatin structure marks key developmental genes in embryonic stem cellsQ27860977
Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factorsQ28473971
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specificationQ28504641
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cellsQ28504716
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesisQ28507642
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in miceQ28511594
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignanciesQ28591763
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelityQ28595004
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencingQ28749183
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsQ29614512
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiationQ29617398
Epigenetic regulation of Hox gene activation: the waltz of methylsQ31147451
Aging and chronic sun exposure cause distinct epigenetic changes in human skinQ33594466
Dynamic changes in the human methylome during differentiationQ33736539
The UCSC Genome Browser database: extensions and updates 2011.Q34075361
Active DNA demethylation: many roads lead to Rome.Q34129576
Organizing axes in time and space; 25 years of colinear tinkeringQ34215299
The three-dimensional architecture of Hox cluster silencingQ34368052
Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acidQ34536795
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).Q34550062
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.Q34574880
Epigenetic inactivation of the HOXA gene cluster in breast cancerQ34580018
From teratocarcinomas to embryonic stem cellsQ34655798
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.Q34762752
Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locusQ34937659
Acquired mutations in TET2 are common in myelodysplastic syndromesQ34984094
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cellsQ35071448
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.Q35640316
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assayQ35720707
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitorsQ35797589
Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.Q36303442
P407language of work or nameEnglishQ1860
P921main subjectactive stateQ111518803
P304page(s)818
P577publication date2012-05-08
P1433published inNature CommunicationsQ573880
P1476titleHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
P478volume3

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cites work (P2860)
Q36882821AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation.
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