Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

scientific article published on 6 July 2011

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2010-12-324707
P8608Fatcat IDrelease_f3gwmk77kjbw7mfsicrr2auh3m
P932PMC publication ID3292425
P698PubMed publication ID21734233
P5875ResearchGate publication ID51472183

P50authorWilliam VainchenkerQ3569009
Eric SolaryQ41021747
Jean-Luc RavanatQ57770144
P2093author name stringLucy A Godley
Elodie Pronier
Bruno Carbonne
Jean-Pierre Le Couédic
Nicole Casadevall
Jérôme Larghero
Nathalie Droin
Audrey Simon
Aparna Vasanthakumar
François Delhommeau
Olivier A Bernard
Isabelle Plo
Jean-Luc Ravanat
Aline Massé
Barbara da Costa Reis Monte Mor
Carole Almire
Frédéric Pendino
Hayat Mokrani
P2860cites workImpaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2Q24306181
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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignanciesQ24648438
DNMT3A Mutations in Acute Myeloid LeukemiaQ27559610
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specificationQ28504641
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiationQ29615366
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiationQ29617398
Mutation in TET2 in myeloid cancersQ29619292
Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometryQ33210828
Acquired mutations in TET2 are common in myelodysplastic syndromesQ34984094
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cellsQ35005985
Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.Q36303442
Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasmsQ37262428
TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemiaQ37470906
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.Q38350881
Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.Q40235276
Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosisQ42879123
Evaluation of DNA adducts, DNA and RNA oxidative lesions, and 3-hydroxybenzo(a)pyrene as biomarkers of DNA damage in lung following intravenous injection of the parent compound in rats.Q42995994
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.Q43267407
Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasmsQ45770967
TET2 mutations in myelodysplasia and myeloid malignanciesQ57734311
Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1Q57740696
The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia veraQ80050823
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2551-2555
P577publication date2011-07-06
P1433published inBloodQ885070
P1476titleInhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors
P478volume118

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