| P50 | author | Zhiqing Liu | Q51063464 |
| P2093 | author name string | Xiaodong Cheng | |
| | Haiying Chen | |
| | Jia Zhou | |
| | Christopher Wild | |
| | Na Ye | |
| | Fang C Mei | |
| | Haijun Chen | |
| | Yingmin Zhu | |
| P2860 | cites work | Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP | Q22008544 |
| | A family of cAMP-binding proteins that directly activate Rap1 | Q22008551 |
| | Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs | Q22253953 |
| | Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B | Q24317583 |
| | PKA: lessons learned after twenty years | Q26823926 |
| | Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions | Q27022162 |
| | The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes | Q27974567 |
| | A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists | Q28478997 |
| | The auto-inhibitory role of the EPAC hinge helix as mapped by NMR | Q28485307 |
| | Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC). | Q30405298 |
| | Epac signaling is required for hippocampus-dependent memory retrieval | Q30440218 |
| | Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform | Q31029983 |
| | Cyclic nucleotide analogs as biochemical tools and prospective drugs | Q34047351 |
| | Epac: defining a new mechanism for cAMP action | Q34091443 |
| | Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). | Q34174771 |
| | cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension | Q34207668 |
| | Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC) | Q34211343 |
| | 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. | Q34274771 |
| | A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion | Q34306163 |
| | Isoform-specific antagonists of exchange proteins directly activated by cAMP | Q34307662 |
| | Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac | Q34310769 |
| | Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1 | Q34319327 |
| | Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements | Q34356123 |
| | Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses | Q34384331 |
| | Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus | Q34399575 |
| | Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo | Q34447181 |
| | Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window". | Q34467944 |
| | Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells | Q34468359 |
| | Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state | Q34490708 |
| | Identification and characterization of small molecules as potent and specific EPAC2 antagonists | Q34535973 |
| | Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton | Q34553080 |
| | Epac proteins: multi-purpose cAMP targets | Q34579147 |
| | Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors | Q34667012 |
| | Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. | Q34718424 |
| | The many roles for fluorine in medicinal chemistry | Q34788078 |
| | Epac and PKA: a tale of two intracellular cAMP receptors | Q34792821 |
| | Mapping allostery through the covariance analysis of NMR chemical shifts | Q34794802 |
| | Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling | Q34795751 |
| | 8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. | Q34797203 |
| | DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms | Q34826504 |
| | Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function | Q34929964 |
| | Dynamically driven ligand selectivity in cyclic nucleotide binding domains | Q34978413 |
| | The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cells | Q35035803 |
| | Opposing roles of PKA and EPAC in the cAMP-dependent regulation of schwann cell proliferation and differentiation [corrected] | Q35070200 |
| | 7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents | Q35190660 |
| | The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants. | Q35743330 |
| | Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist | Q36634333 |
| | Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression | Q36635113 |
| | Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents | Q36641981 |
| | Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility | Q37017307 |
| | Cyclic nucleotide-regulated cation channels | Q37340786 |
| | Cyclic nucleotide-gated channels | Q37352765 |
| | The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function | Q37632467 |
| | Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications | Q37852843 |
| | cAMP-dependent allostery and dynamics in Epac: an NMR view. | Q37977182 |
| | Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR. | Q38197317 |
| | Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells | Q39726942 |
| | cAMP controls the restoration of endothelial barrier function after thrombin-induced hyperpermeability via Rac1 activation. | Q41869883 |
| | A tool set to map allosteric networks through the NMR chemical shift covariance analysis | Q41924839 |
| | Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure | Q42066795 |
| | Epac-inhibitors: facts and artefacts | Q42937492 |
| | Epac: a new cAMP target and new avenues in cAMP research | Q43859972 |
| | Cyclic nucleotide research -- still expanding after half a century | Q44123887 |
| | Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states | Q46921842 |
| | Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval | Q48464032 |
| | Cyclic nucleotide analogs as probes of signaling pathways. | Q55049561 |
| | Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP | Q62273240 |
| | Fluorine in medicinal chemistry | Q80497522 |
| | The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1) | Q86483624 |
| P433 | issue | 15 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 6033-6047 | |
| P577 | publication date | 2015-07-16 | |
| P1433 | published in | Journal of Medicinal Chemistry | Q900316 |
| P1476 | title | Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists | |
| P478 | volume | 58 | |