Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase

scientific article published on July 2004

Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase is …
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scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-04-0325
P932PMC publication ID2374668
P698PubMed publication ID15269141

P50authorSteven RosenbergQ2347448
P2093author name stringYong Li
Paul F Robbins
John P Riley
Maria R Parkhurst
Takehito Igarashi
P2860cites workIsolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalytiQ58380161
Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the DonorQ72059554
The renal cell carcinoma-associated antigen G250 encodes a human leukocyte antigen (HLA)-A2.1-restricted epitope recognized by cytotoxic T lymphocytesQ73163073
Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanomaQ74535384
Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2)Q77536089
Antitumor immunization with a minimal peptide epitope (G9-209-2M) leads to a functionally heterogeneous CTL responseQ77996343
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalizationQ24310670
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
Cytotoxic T cell immunity against telomerase reverse transcriptase in humansQ24676613
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytesQ28139460
Creation of human tumour cells with defined genetic elementsQ28141602
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alphaQ28251443
Telomere length regulationQ28290143
A survey of telomerase activity in human cancerQ29614858
Can hTERT peptide (540-548) -specific CD8 T cells recognize and kill tumor cells?Q33187012
Progress in human tumour immunology and immunotherapyQ34253585
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanomaQ36119828
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell deathQ36742412
Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan AQ37003339
Stimulation of tumor-reactive T lymphocytes using mixtures of synthetic peptides derived from tumor-associated antigens with diverse MHC binding affinitiesQ40649080
Lack of tumor recognition by hTERT peptide 540-548-specific CD8(+) T cells from melanoma patients reveals inefficient antigen processing.Q40782201
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomeraseQ41053498
Antigens recognized by T-lymphocytes on human tumoursQ41505346
Clinical implications of telomerase in cancerQ41583670
Identification of a new shared HLA-A2.1 restricted epitope from the melanoma antigen tyrosinaseQ42651562
Isolation of tyrosinase-specific CD8+ and CD4+ T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virusQ45766815
Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.Q51051603
Inhibition of telomerase limits the growth of human cancer cells.Q52536487
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectimmunizationQ1415366
P304page(s)4688-4698
P577publication date2004-07-01
P1433published inClinical Cancer ResearchQ332253
P1476titleImmunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase
P478volume10