| scholarly article | Q13442814 |
| P50 | author | Angelika Schnieke | Q59545433 |
| P2093 | author name string | J Cooper | |
| A Colman | |||
| A Stacey | |||
| D W Melton | |||
| J McWhir | |||
| P2860 | cites work | Organization and sequence of the human alpha-lactalbumin gene | Q24529461 |
| Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy | Q24603756 | ||
| The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain | Q28586297 | ||
| Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes | Q29547355 | ||
| Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice | Q29547898 | ||
| Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells | Q33616210 | ||
| Introduction of specific point mutations into RNA polymerase II by gene targeting in mouse embryonic stem cells: evidence for a DNA mismatch repair mechanism | Q33638625 | ||
| Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection | Q33927120 | ||
| Conservative intrachromosomal recombination between inverted repeats in mouse cells: association between reciprocal exchange and gene conversion | Q33954017 | ||
| Genetics of human cess line. IV. DNA-mediated heritable transformation of a biochemical trait | Q34253762 | ||
| Altering genes in animals by gene targeting | Q34420633 | ||
| The effects of terminal heterologies on gene targeting by insertion vectors in embryonic stem cells | Q34978228 | ||
| Genomic targeting with purified Cre recombinase | Q34981597 | ||
| Modifying the mouse: design and desire | Q35300688 | ||
| Manipulating the genome by homologous recombination in embryonic stem cells | Q36064923 | ||
| Plasmid and bacteriophage vectors for excision of intact inserts | Q36298002 | ||
| An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region | Q36534473 | ||
| Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants | Q36596960 | ||
| Double-strand gap repair in a mammalian gene targeting reaction | Q36730881 | ||
| Production of homozygous mutant ES cells with a single targeting construct | Q36815597 | ||
| Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells | Q36958779 | ||
| Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs | Q37045150 | ||
| Correction of a human beta S-globin gene by gene targeting | Q37511664 | ||
| A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency | Q40533270 | ||
| Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells | Q40640321 | ||
| Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus | Q40655712 | ||
| Location of crossovers during gene targeting with insertion and replacement vectors | Q41562649 | ||
| Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: inactivation of the mouse ERCC-1 gene | Q41616098 | ||
| Metabolic co-operation in HGPRT+ and HGPRT- embryonal carcinoma cells | Q44020986 | ||
| Sequence of the murine alpha-lactalbumin-encoding cDNA: interspecies comparison of the coding frame and deduced pre-protein | Q44569823 | ||
| Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. | Q52486323 | ||
| Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells | Q57557434 | ||
| Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting | Q60016929 | ||
| Homologous recombination between repeated chromosomal sequences in mouse cells | Q70974143 | ||
| Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments | Q72216655 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | gene targeting | Q211083 |
| P304 | page(s) | 1009-1016 | |
| P577 | publication date | 1994-02-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice | |
| P478 | volume | 14 |
| Q33773897 | A gene-targeting approach identifies a function for the first intron in expression of the alpha1(I) collagen gene |
| Q28593147 | A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy |
| Q52164706 | A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells. |
| Q73717592 | A simple genotyping assay for the Hprt null allele in mice produced from the HM-1 and E14TG2a mouse embryonic stem cell lines |
| Q40925876 | Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer |
| Q33702793 | Analysis of mammalian cis-regulatory DNA elements by homologous recombination |
| Q80326622 | Biomedical and agricultural applications of animal transgenesis |
| Q57198351 | Conditional gene targeting |
| Q57198382 | Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies |
| Q34725959 | Creation and phenotypic analysis of alpha-lactalbumin-deficient mice |
| Q24310507 | DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability |
| Q30833243 | Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43. |
| Q36668182 | Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy |
| Q37416903 | Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues |
| Q41298105 | Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations |
| Q33543443 | ENU-induced mutant mice for a next-generation gene-targeting system |
| Q77567177 | Efficient repetitive alteration of the mouse Huntington's disease gene by management of background in the tag and exchange gene targeting strategy |
| Q38126465 | Engineering subtle targeted mutations into the mouse genome |
| Q40873972 | Enhancing the efficiency of introducing precise mutations into the mouse genome by hit and run gene targeting |
| Q38337835 | Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals |
| Q60287328 | Factors affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxp system |
| Q38340269 | G protein-coupled receptors: functional and mechanistic insights through altered gene expression |
| Q39758786 | Gene modification via "plug and socket" gene targeting |
| Q41995159 | Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis |
| Q40382136 | Genetic knockouts in mice: an update |
| Q33709310 | Genetically modified animals in pharmacological research: future trends |
| Q24522393 | I-SceI-induced gene replacement at a natural locus in embryonic stem cells |
| Q48924271 | Insertion of a foreign gene into the beta-casein locus by Cre-mediated site-specific recombination |
| Q40401732 | Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis |
| Q28586568 | Introduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: a comparison of homologous recombination methods |
| Q39720349 | Introduction of precise alterations into the mouse genome with high efficiency by stable tag-exchange gene targeting: implications for gene targeting in ES cells |
| Q24564332 | Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice |
| Q42796469 | Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates |
| Q34046721 | Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9. |
| Q28510546 | Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression |
| Q28379342 | Mice with type 2 and 3 Gaucher disease point mutations generated by a single insertion mutagenesis procedure |
| Q33923742 | Modification and repression of genes expressed in the mammary gland using gene targeting and other technologies |
| Q34636707 | Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene |
| Q37435347 | Overview: generation of gene knockout mice |
| Q39585969 | Pre-selection of integration sites imparts repeatable transgene expression |
| Q36558820 | Recycling selectable markers in mouse embryonic stem cells |
| Q47771907 | Role of endogenous brain "ouabain" in the sympathoexcitatory and pressor effects of sodium |
| Q37384432 | Single-copy transgenic mice with chosen-site integration |
| Q34637962 | Stability of HPRT marker gene expression at different gene-targeted loci: observing and overcoming a position effect. |
| Q30050478 | Talking about a Revolution |
| Q24631266 | Targeted transgenesis |
| Q40427854 | Targeting the mouse genome: a compendium of knockouts (part II) |
| Q33650414 | Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis |
| Q40510406 | The human SCGB2A2 (mammaglobin-1) promoter/enhancer in a helper-dependent adenovirus vector directs high levels of transgene expression in mammary carcinoma cells but not in normal nonmammary cells |
| Q42563824 | The molecular basis of multiple vector insertion by gene targeting in mammalian cells |
| Q77798567 | Transgenic animal bioreactors in biotechnology and production of blood proteins |
| Q35946322 | Transgenic animals and nutrition research. |
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