Psoriasis: genetic associations and immune system changes.

scientific article published on 9 November 2006

Psoriasis: genetic associations and immune system changes. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/SJ.GENE.6364351
P698PubMed publication ID17093502
P5875ResearchGate publication ID6702796

P50authorAnne M. BowcockQ30348371
P2093author name stringLiu Y
Krueger JG
P2860cites workRefined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamationQ24291049
Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive propertiesQ24291982
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgarisQ24676186
A haplotype map of the human genomeQ24679827
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritisQ28182995
A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasisQ28183038
Identification of six novel polymorphisms in the human corneodesmosin geneQ28199751
Molecular physiology of cation-coupled Cl? cotransport: the SLC12 familyQ28203488
Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility lociQ28209261
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humansQ28211167
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17Q28213628
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger proteinQ28244075
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetesQ28248848
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritisQ28267921
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetesQ28271534
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.Q28273794
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitisQ28303063
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasiaQ28591205
Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17qQ28610601
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Runx transcription factors and the developmental balance between cell proliferation and differentiation.Q30332928
Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgarisQ33757065
Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map.Q34115785
Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locusQ34116785
Human keratinocytes are a major source of cutaneous platelet-derived growth factorQ34170407
Aberrant integrin expression during epidermal wound healing and in psoriatic epidermisQ34220741
Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokinesQ34234920
Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)Q34245272
Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemiasQ34448183
Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgarisQ34468739
Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.Q34474419
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiatQ34505900
Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese populationQ34537967
S100 proteins in the epidermisQ34548562
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 geneQ34658035
Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expressionQ35774136
Current concepts in the immunopathogenesis of psoriasisQ35902657
The insulin-like growth factor I receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptorQ36231140
Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healingQ36231924
Getting under the skin: the immunogenetics of psoriasisQ36247085
Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseasesQ36282160
Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cellsQ36368842
Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage developmentQ36376366
Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patientsQ36993807
Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide arrayQ38356616
Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cellsQ40395229
Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans population.Q40506620
Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locusQ40725419
Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammationQ40734155
Expression of vascular endothelial growth factor in normal epidermis, epithelial tumors and cultured keratinocytesQ42437628
Differential expression of phosphorylated NF-kappaB/RelA in normal and psoriatic epidermis and downregulation of NF-kappaB in response to treatment with etanerceptQ42479845
Evaluation of the IRF-2 gene as a candidate for PSORS3.Q42619643
Evidence for interaction between psoriasis-susceptibility loci on chromosomes 6p21 and 1q21.Q42698848
Mapping of psoriasis to 17q terminus.Q43073355
Genetic analysis of PSORS2 markers in a UK dataset supports the association between RAPTOR SNPs and familial psoriasis.Q43073651
Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasisQ43650481
IL-12 prevents the inhibitory effects of cis-urocanic acid on tumor antigen presentation by Langerhans cells: implications for photocarcinogenesisQ43803680
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.Q45196039
Investigation of the chromosome 17q25 PSORS2 locus in atopic dermatitisQ46865521
A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgarisQ46960833
Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear lateQ47588197
Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profilingQ47598277
Interleukin-10 promoter polymorphism IL10.G and familial early onset psoriasisQ47672947
Psoriasis is not associated with IL-12p70/IL-12p40 production and IL12B promoter polymorphismQ47721685
A 4.2 kb upstream region of the human corneodesmosin gene directs site-specific expression in hair follicles and hyperkeratotic epidermis of transgenic miceQ47758391
Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris.Q48275426
Corneodesmosin expression in psoriasis vulgaris differs from normal skin and other inflammatory skin disordersQ49240008
CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry.Q52918582
Molecular characterization of a balanced chromosome translocation in psoriasis vulgarisQ56974324
A non-HLA gene within the MHC in psoriasisQ57149542
Psoriasis Susceptibility Locus on 18p Revealed by Genome Scan in Finnish Families Not Associated with PSORS1Q57232750
Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCRQ57275020
Association of TNF -238 and -308 Promoter Polymorphisms with Psoriasis Vulgaris and Psoriatic Arthritis but not with Pustulosis PalmoplantarisQ57619885
Searching for Psoriasis Susceptibility Genes in Italy: Genome Scan and Evidence for a New Locus on Chromosome 1Q58193968
Prominent Production of IL-20 by CD68+/CD11c+ Myeloid-Derived Cells in Psoriasis: Gene Regulation and Cellular EffectsQ60683098
Psoriasis Genetics: The Way ForwardQ61647709
The genetics of psoriasis: a complex disorder of the skin and immune systemQ61647805
A Phase I Study Evaluating the Safety, Pharmacokinetics, and Clinical Response of a Human IL-12 p40 Antibody in Subjects with Plaque PsoriasisQ61853653
Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasisQ61990617
Changes in keratinocyte maturation during wound healingQ69002778
Predominance of "memory" T cells (CD4+, CDw29+) over "naive" T cells (CD4+, CD45R+) in both normal and diseased human skinQ69304365
Psoriasis and alpha-interferonQ69883338
Psoriasis and HLA-Cw6Q71233054
Stratum corneum structure and function correlates with phenotype in psoriasisQ71572086
The genetics of psoriasisQ72765417
Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgarisQ73778362
IL-10 promoter polymorphisms influence disease severity and course in psoriasisQ73876813
Interleukin-10 promoter polymorphism in psoriasisQ74025047
Intraepidermal lymphocytes in psoriatic lesions are activated GMP-17(TIA-1)+CD8+CD3+ CTLs as determined by phenotypic analysisQ74377163
Combined analysis of polymorphisms of the tumor necrosis factor-alpha and interleukin-10 promoter regions and polymorphic xenobiotic metabolizing enzymes in psoriasisQ78197650
Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseasesQ78553681
Cytokines and cytokine receptorsQ81013267
Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasisQ81739598
P433issue1
P304page(s)1-12
P577publication date2006-11-09
P1433published inGenes and ImmunityQ15745246
P1476titlePsoriasis: genetic associations and immune system changes
P478volume8

Reverse relations

cites work (P2860)
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