Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice

scientific article published on 12 February 2016

Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1502126
P932PMC publication ID4779665
P698PubMed publication ID26873987

P50authorDonald T GraciasQ57005032
Yvonne M MuellerQ57005064
Joseph A. FraiettaQ85544113
Alina C BoesteanuQ87031316
Ogan K KumovaQ90399190
Jillian L ThayerQ90656245
Peter D KatsikisQ42434461
Jennifer L HopeQ47550331
Alison J CareyQ47550360
P2093author name stringDavid B H van Zessen
P2860cites workCircos: an information aesthetic for comparative genomicsQ29547653
Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tractQ30308521
Cell-mediated protection in influenza infection.Q30353071
Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infectionQ30433900
A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cellsQ33459148
Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.Q33787236
Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoireQ33993575
The migration of T cells in response to influenza virus is altered in neonatal miceQ34076992
Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell MemoryQ34190038
Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccinesQ34359350
The use of a neonatal mouse model to study respiratory syncytial virus infectionsQ34549253
Regulation and chance in the ontogeny of B and T cell antigen receptor repertoiresQ34981948
Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responsesQ34998204
Reduction of influenza virus titer and protection against influenza virus infection in infant mice fed Lactobacillus casei ShirotaQ35523570
Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected miceQ35586896
Enhanced type 1 immunity after secondary viral challenge in mice primed as neonates.Q52010710
Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2-biased pattern which persists after adult boosting.Q52888854
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cellsQ53549666
Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic CellsQ56338635
Efficient immune responses in mice lacking N-region diversityQ63952511
Exclusive Th2 primary effector function in spleens but mixed Th1/Th2 function in lymph nodes of murine neonatesQ73458399
Flow cytometric analysis of the Vbeta repertoire in healthy controlsQ74082123
CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal primingQ78109668
Neonatal CD8+ T cells are slow to develop into lytic effectors after HSV infection in vivoQ80201769
Persistent antigen presentation after acute vesicular stomatitis virus infectionQ35635383
The Neonatal CD4+ T Cell Response to a Single Epitope Varies in Genetically Identical MiceQ35988534
Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.Q36008100
Distribution and evolution of T-cell receptor Vbeta repertoire on peripheral blood lymphocytes of newborn infants of human immunodeficiency virus (HIV)-infected mothers: differential display on CD4 and CD8 T cells and effect of HIV infectionQ36095159
Junctional sequences of fetal T cell receptor beta chains have few N regionsQ36230134
DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early lifeQ36556802
Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoireQ36816022
Priming of virus-immune memory T cells in newborn mice.Q37080003
Inchoate CD8+ T cell responses in neonatal mice permit influenza-induced persistent pulmonary dysfunctionQ37137188
Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosineQ37189501
Induction of protective immunity to Listeria monocytogenes in neonates.Q37252100
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitopeQ37415551
Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequencesQ37627838
Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infectionQ37692143
From vaccine practice to vaccine science: the contribution of human immunology to the prevention of infectious diseaseQ37837477
Timely and spatially regulated maturation of B and T cell repertoire during human fetal developmentQ39035263
Development of the primary antibody repertoireQ39682083
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytesQ40669542
Contemporary analysis of MHC-related immunodominance hierarchies in the CD8+ T cell response to influenza A virusesQ40860957
Structure and function of natural antibodies.Q40948626
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.Q42205543
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell HelpQ42642562
Probiotics prevent death caused by Citrobacter rodentium infection in neonatal miceQ43229802
Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurementQ44764092
Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responsesQ45406272
Latency and persistence of respiratory syncytial virus despite T cell immunityQ45697249
CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particlesQ45729231
Virus-specific CD8+ T cells in primary and secondary influenza pneumoniaQ45755057
Continued maturation of thymic emigrants in the peripheryQ48022294
Early restriction of the human antibody repertoireQ48335513
Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants.Q50928106
The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants.Q50999785
Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice.Q51242526
Memory CD8+ T cells require CD28 costimulation.Q51970076
Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection.Q51985457
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectTCR repertoireQ106577188
rapid evolutionQ118582888
P304page(s)2602-2613
P577publication date2016-02-12
P1433published inJournal of ImmunologyQ3521441
P1476titleRapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice
P478volume196