Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump.

scientific article published on 22 January 2013

Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M112.436915
P932PMC publication ID3591597
P698PubMed publication ID23341466

P50authorMuthu PeriasamyQ41535997
P2093author name stringNaresh C Bal
Danesh H Sopariwala
Sana A Shaikh
Sanjaya K Sahoo
P2860cites workSarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)Q24298196
Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPaseQ24313260
Sarcolipin uncouples hydrolysis of ATP from accumulation of Ca2+ by the Ca2+-ATPase of skeletal-muscle sarcoplasmic reticulumQ24533577
Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase.Q24541329
Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholambanQ24678050
Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractilityQ24679092
Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolutionQ27625023
Structural changes in the calcium pump accompanying the dissociation of calciumQ27639472
The presence of sarcolipin results in increased heat production by Ca(2+)-ATPase.Q51932184
Cooperative calcium binding and ATPase activation in sarcoplasmic reticulum vesiclesQ52762748
Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulumQ59054428
Functional consequences of alterations to Glu309, Glu771, and Asp800 in the Ca(2+)-ATPase of sarcoplasmic reticulumQ67901996
Functional consequences of alterations to amino acids at the M5S5 boundary of the Ca(2+)-ATPase of sarcoplasmic reticulum. Mutation Tyr763-->Gly uncouples ATP hydrolysis from Ca2+ transportQ72411330
Analysis of sarcoplasmic reticulum Ca2+ transport and Ca2+ ATPase enzymatic properties using mouse cardiac tissue homogenatesQ77380264
Solid-state NMR and functional measurements indicate that the conserved tyrosine residues of sarcolipin are involved directly in the inhibition of SERCA1Q80579618
Critical role of Glu40-Ser48 loop linking actuator domain and first transmembrane helix of Ca2+-ATPase in Ca2+ deocclusion and release from ADP-insensitive phosphoenzymeQ81324270
Cross-linking of C-terminal residues of phospholamban to the Ca2+ pump of cardiac sarcoplasmic reticulum to probe spatial and functional interactions within the transmembrane domainQ82915874
Transmembrane helix M6 in sarco(endo)plasmic reticulum Ca(2+)-ATPase forms a functional interaction site with phospholamban. Evidence for physical interactions at other sitesQ28146231
Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulationQ28509802
Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null miceQ28509941
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in miceQ28585152
Oligomeric interactions of sarcolipin and the Ca-ATPaseQ30504289
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.Q30540446
Mutation of aspartic acid-351, lysine-352, and lysine-515 alters the Ca2+ transport activity of the Ca2+-ATPase expressed in COS-1 cellsQ33572777
Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholambanQ33661730
Superinhibitory phospholamban mutants compete with Ca2+ for binding to SERCA2a by stabilizing a unique nucleotide-dependent conformational stateQ34121188
A calcium pump made visibleQ34774330
Regulation of Sarco(endo)plasmic Reticulum Ca2+ Adenosine Triphosphatase by Phospholamban and Sarcolipin Implication for Cardiac Hypertrophy and FailureQ35122027
Phospholamban: a crucial regulator of cardiac contractilityQ35167969
Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulumQ35799963
The effect of calcium ionophores on fragmented sarcoplasmic reticulumQ36428783
Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPaseQ36795004
Concerted conformational effects of Ca2+ and ATP are required for activation of sequential reactions in the Ca2+ ATPase (SERCA) catalytic cycleQ36851517
Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathologyQ37002247
Interaction sites among phospholamban, sarcolipin, and the sarco(endo)plasmic reticulum Ca(2+)-ATPaseQ37021839
Structural and dynamic basis of phospholamban and sarcolipin inhibition of Ca(2+)-ATPaseQ37032523
Differential expression of sarcolipin protein during muscle development and cardiac pathophysiologyQ37252432
Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca(2+)-ATPasesQ37695878
Location of high affinity Ca2+-binding sites within the predicted transmembrane domain of the sarcoplasmic reticulum Ca2+-ATPaseQ38344356
Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agentsQ40634835
The regulation of SERCA-type pumps by phospholamban and sarcolipin.Q40645538
Sarcolipin overexpression in rat slow twitch muscle inhibits sarcoplasmic reticulum Ca2+ uptake and impairs contractile function.Q40703397
Physical interactions between phospholamban and sarco(endo)plasmic reticulum Ca2+-ATPases are dissociated by elevated Ca2+, but not by phospholamban phosphorylation, vanadate, or thapsigargin, and are enhanced by ATP.Q40880128
Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species.Q41768288
Close proximity between residue 30 of phospholamban and cysteine 318 of the cardiac Ca2+ pump revealed by intermolecular thiol cross-linking.Q42051533
Co-reconstitution of phospholamban mutants with the Ca-ATPase reveals dependence of inhibitory function on phospholamban structureQ42059035
A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonistsQ42493338
An investigation of the mechanism of inhibition of the Ca(2+)-ATPase by phospholambanQ42983834
Correlation between uncoupled ATP hydrolysis and heat production by the sarcoplasmic reticulum Ca2+-ATPase: coupling effect of fluoride.Q43729084
Specific structural requirements for the inhibitory effect of thapsigargin on the Ca2+ ATPase SERCA.Q44768427
Crystal structure of the calcium pump with a bound ATP analogueQ44960560
Characterization of the inhibition of intracellular Ca2+ transport ATPases by thapsigarginQ45218250
Conformational fluctuations of the Ca2+-ATPase in the native membrane environment. Effects of pH, temperature, catalytic substrates, and thapsigarginQ46432401
Defining the intramembrane binding mechanism of sarcolipin to calcium ATPase using solution NMR spectroscopyQ46977589
Phospholamban and sarcolipin are maintained in the endoplasmic reticulum by retrieval from the ER-Golgi intermediate compartment.Q50696708
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)6881-6889
P577publication date2013-01-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleSarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump
P478volume288

Reverse relations

cites work (P2860)
Q94469423Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool
Q35333572Atomic-level mechanisms for phospholamban regulation of the calcium pump.
Q47971417Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice
Q37678742Ca(2+)/H (+) exchange, lumenal Ca(2+) release and Ca (2+)/ATP coupling ratios in the sarcoplasmic reticulum ATPase
Q28543394Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction
Q35073319Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers
Q47590388Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA.
Q41045820Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function
Q50755664Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin-NFAT signaling in skeletal muscle of DM1 mice.
Q47369284Muscle Non-shivering Thermogenesis and Its Role in the Evolution of Endothermy.
Q96303464P2X7 Receptor in the Management of Energy Homeostasis: Implications for Obesity, Dyslipidemia, and Insulin Resistance
Q38690026Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?
Q37232028Phosphorylated phospholamban stabilizes a compact conformation of the cardiac calcium-ATPase
Q35789147Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity
Q38713977Role of SERCA Pump in Muscle Thermogenesis and Metabolism
Q34634136S-palmitoylation and s-oleoylation of rabbit and pig sarcolipin
Q38628349Salsalate Activates Skeletal Muscle Thermogenesis and Protects Mice from High-Fat Diet Induced Metabolic Dysfunction
Q35536274Sarcolipin Is a Key Determinant of the Basal Metabolic Rate, and Its Overexpression Enhances Energy Expenditure and Resistance against Diet-induced Obesity.
Q55381179Sarcolipin Makes Heat, but Is It Adaptive Thermogenesis?
Q42943217Sarcolipin Promotes Uncoupling of the SERCA Ca2+ Pump by Inducing a Structural Rearrangement in the Energy-Transduction Domain
Q41834129Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state.
Q36302421Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice
Q36385083Sarcolipin is a novel regulator of muscle metabolism and obesity
Q35437635Sarcolipin overexpression improves muscle energetics and reduces fatigue
Q38956714Sarcolipin: A Key Thermogenic and Metabolic Regulator in Skeletal Muscle
Q61427687Sarcoplasmic reticulum Ca2+ uptake and leak properties, and SERCA isoform expression, in type I and type II fibres of human skeletal muscle
Q42804825Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism
Q35783136Specific Activation of the Plant P-type Plasma Membrane H+-ATPase by Lysophospholipids Depends on the Autoinhibitory N- and C-terminal Domains.
Q33803663Structural dynamics and conformational equilibria of SERCA regulatory proteins in membranes by solid-state NMR restrained simulations.
Q88210354Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin
Q92460678The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study
Q35662355The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport
Q57491001The Role of Sarcolipin in Muscle Non-shivering Thermogenesis
Q27679847The Structural Basis for Phospholamban Inhibition of the Calcium Pump in Sarcoplasmic Reticulum
Q38819582The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation.
Q38366647The regulation of sarco(endo)plasmic reticulum calcium-ATPases (SERCA).
Q28603354The role of skeletal-muscle-based thermogenic mechanisms in vertebrate endothermy

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