The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation

scientific article published on 22 January 2013

The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.438374
P932PMC publication ID3591636
P698PubMed publication ID23341449

P2093author name stringKaren J Colley
Matthew G Thompson
Deirdre A Foley
P2860cites workGenetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.Q42672496
Enzyme-dependent variations in the polysialylation of the neural cell adhesion molecule (NCAM) in vivoQ46912056
The minimal structural domains required for neural cell adhesion molecule polysialylation by PST/ST8Sia IV and STX/ST8Sia II.Q47854870
Identification of a novel neural cell adhesion molecule-related gene with a potential role in selective axonal projectionQ48044402
OCAM: A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axonsQ48047016
A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylationQ48412703
Polysialic acid is associated with sodium channels and the neural cell adhesion molecule N-CAM in adult rat brainQ48480824
Direct binding of polysialic acid to a brain-derived neurotrophic factor depends on the degree of polymerizationQ48923084
Polysialic acid, a unique glycan that is developmentally regulated by two polysialyltransferases, PST and STX, in the central nervous system: from biosynthesis to function.Q52183181
Evaluation of polysialic acid in the diagnosis of Wilms' tumor. A comparative study on urinary tract tumors and non-neuroendocrine tumors.Q52253958
Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transportQ70669682
Polysialic acid in human milk. CD36 is a new member of mammalian polysialic acid-containing glycoproteinQ78953049
Direct evidence that neural cell adhesion molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesionQ94412058
Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia IIIQ22253906
A human STX cDNA confers polysialic acid expression in mammalian cellsQ24310385
Molecular characterization of eukaryotic polysialyltransferase-1Q24313370
Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndromeQ24318316
GlyProt: in silico glycosylation of proteinsQ24812315
Structure and Mutagenesis of Neural Cell Adhesion Molecule Domains: EVIDENCE FOR FLEXIBILITY IN THE PLACEMENT OF POLYSIALIC ACID ATTACHMENT SITESQ27662651
Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion moleculeQ27666681
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicingQ28116105
Biological roles of oligosaccharides: all of the theories are correctQ29616459
Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapyQ33788355
Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brainQ33933086
ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes.Q34140948
Sequences from the first fibronectin type III repeat of the neural cell adhesion molecule allow O-glycan polysialylation of an adhesion molecule chimeraQ34251447
Characterization of mouse ST8Sia II (STX) as a neural cell adhesion molecule-specific polysialic acid synthase. Requirement of core alpha1,6-linked fucose and a polypeptide chain for polysialylationQ34388496
Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST.Q34434925
In vivo autopolysialylation and localization of the polysialyltransferases PST and STX.Q34483408
Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brainsQ34502678
Sequences at the interface of the fifth immunoglobulin domain and first fibronectin type III repeat of the neural cell adhesion molecule are critical for its polysialylationQ34575750
Role of glycosylation in developmentQ35799981
Presence of the long chain form of polysialic acid of the neural cell adhesion molecule in Wilms' tumor. Identification of a cell adhesion molecule as an oncodevelopmental antigen and implications for tumor histogenesis.Q35819105
Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoidsQ35830462
Sequences prior to conserved catalytic motifs of polysialyltransferase ST8Sia IV are required for substrate recognitionQ35838994
Dissecting polysialic acid and NCAM functions in brain developmentQ36994547
Polysialic acid in the plasticity of the developing and adult vertebrate nervous systemQ37024530
Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM.Q37257286
Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, OCAM.Q38315082
Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactionsQ40094051
Polysialic acid on the neural cell adhesion molecule correlates with expression of polysialyltransferases and promotes neuroblastoma cell growthQ41062838
Autocatalytic polysialylation of polysialyltransferase-1.Q41079025
Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acidQ41230450
Polysialic acid and the regulation of cell interactionsQ41238957
A developmentally regulated member of the sialyltransferase family (ST8Sia II, STX) is a polysialic acid synthaseQ41283735
Protein determinants for specific polysialylation of the neural cell adhesion moleculeQ41324075
In vitro and in vivo growth of clonal sublines of human small cell lung carcinoma is modulated by polysialic acid of the neural cell adhesion moleculeQ41496253
Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophreniaQ42156149
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectcell adhesionQ187640
P304page(s)7282-7293
P577publication date2013-01-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation
P478volume288

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cites work (P2860)
Q47400925Autopolysialylation of polysialyltransferases is required for polysialylation and polysialic acid chain elongation on select glycoprotein substrates
Q33974520Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: role in phagocytosis.
Q33659849Glycobiology of neuroblastoma: impact on tumor behavior, prognosis, and therapeutic strategies
Q28071519NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being?
Q28535224Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration
Q38265379Polysialic acid: biosynthesis, novel functions and applications
Q36849985Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans.
Q26995291Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration
Q39038778Sialylation of N-glycans: mechanism, cellular compartmentalization and function.
Q24338493Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation
Q41566450The Polybasic Region of the Polysialyltransferase ST8Sia-IV Binds Directly to the Neural Cell Adhesion Molecule, NCAM.

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